Institution
Ford Motor Company
Company•Dearborn, Michigan, United States•
About: Ford Motor Company is a company organization based out in Dearborn, Michigan, United States. It is known for research contribution in the topics: Internal combustion engine & Clutch. The organization has 36123 authors who have published 51450 publications receiving 855200 citations. The organization is also known as: Ford Motor & Ford Motor Corporation.
Topics: Internal combustion engine, Clutch, Control theory, Torque, Exhaust gas
Papers published on a yearly basis
Papers
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TL;DR: A recent survey of pegmatite, brine and other types of lithium deposits is presented in this article, where the authors compare their potential for large-scale, long-term production.
576 citations
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TL;DR: The data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury, and indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals.
Abstract: We tested the hypothesis that transplantation of bone marrow stromal cells (MSCs) into the spinal cord after a contusion injury promotes functional outcome. Rats (n = 31) were subjected to a weight driven implant injury. MSCs or phosphate buffered saline was injected into the spinal cord 1 week after injury. Sections of tissue were analyzed by double-labeled immunohistochemistry for MSC identification. Functional outcome measurements using the Basso-Beattie-Bresnehan score were performed weekly to 5 weeks post-injury. The data indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals. Scattered cells derived from MSCs expressed neural protein markers. These data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury.
575 citations
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TL;DR: It is demonstrated that intravenously administered male MSCs increase bFGF expression, reduce apoptosis, promote endogenous cellular proliferation, and improve functional recovery after stroke in female rats.
Abstract: The present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by which treatment of stroke with bone marrow stromal cells (MSCs) improves neurological functional recovery. Additionally, for the first time, we treated cerebral ischemia in female rats with intraveneous administration of MSCs. Female rats were subjected to 2 hr of middle cerebral artery occlusion (MCAo), followed by an injection of 3 x 10(6) male (for Y chromosome labeling) rat MSCs or phosphate-buffered saline (PBS) into the tail vein 24 hr after MCAo. All animals received daily injection of bromodeoxyuridine (BrdU; 50 mg/kg, i.p.) for 13 days after treatment for identification of newly synthesized DNA. Animals were sacrificed at 14 days after MCAo. Behavioral tests (rotarod and adhesive-removal tests) were performed. In situ hybridization, immunohistochemistry, and terminal deoxynucleotidyltransferase (TdT)-mediated dUTP-biotin nick-end labeling (TUNEL) were performed to identify transplanted MSCs (Y chromosome), BrdU, bFGF, and apoptotic cells in the brain. Significant recovery of behavior was found in MSC-treated rats at 7 days in the somatosensory test and at 14 days in the motor test after MCAo compared with control, PBS-treated animals (P<.05). MSCs were found to survive and preferentially localize to the ipsilateral ischemic hemisphere. Significantly more BrdU-positive cells were located in the subventricular zone (P<.05), and significantly fewer apoptotic cells and more bFGF immunoreactive cell were found in the ischemic boundary area (P<.05) of MSC-treated rats than in PBS-treated animals. Here we demonstrate that intravenously administered male MSCs increase bFGF expression, reduce apoptosis, promote endogenous cellular proliferation, and improve functional recovery after stroke in female rats.
575 citations
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TL;DR: It is suggested that focal cerebral ischemia induces transient and regional specific increases in cell proliferation in the ipsilateral hemisphere and that proliferating progenitor cells may exist in the adult cortex.
573 citations
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TL;DR: The union of catalysts and the automobile has been one of the greatest successes of heterogeneous catalysis over the last 25 years as mentioned in this paper, and there will be continued research and development activity focused also on downstream applications (i.e. exhaust emission aftertreatment), especially for fuelefficient, lean-burn vehicles, both diesel and spark-ignited.
566 citations
Authors
Showing all 36140 results
Name | H-index | Papers | Citations |
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Anil K. Jain | 183 | 1016 | 192151 |
Markus Antonietti | 176 | 1068 | 127235 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Jack Hirsh | 146 | 734 | 86332 |
Galen D. Stucky | 144 | 958 | 101796 |
Federico Capasso | 134 | 1189 | 76957 |
Peter Stone | 130 | 1229 | 79713 |
Gerald R. Crabtree | 128 | 371 | 60973 |
Douglas A. Lauffenburger | 122 | 705 | 55326 |
Abass Alavi | 113 | 1298 | 56672 |
Mark E. Davis | 113 | 568 | 55334 |
Keith Beven | 110 | 514 | 61705 |
Naomi Breslau | 107 | 254 | 42029 |
Fei Wang | 107 | 1824 | 53587 |
Jun Yang | 107 | 2090 | 55257 |