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Institution

Ford Motor Company

CompanyDearborn, Michigan, United States
About: Ford Motor Company is a company organization based out in Dearborn, Michigan, United States. It is known for research contribution in the topics: Internal combustion engine & Clutch. The organization has 36123 authors who have published 51450 publications receiving 855200 citations. The organization is also known as: Ford Motor & Ford Motor Corporation.


Papers
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Journal ArticleDOI
TL;DR: In this article, a general solution was developed for predicting the equilibrated shapes of small particles resting upon solid substrates, which describes the dependence of the particle shape upon the anisotropy of the surface tension of a particle and upon the binding between the particle and the substrate.

488 citations

Journal ArticleDOI
TL;DR: The presence and anatomical location of cells exhibiting DNA fragmentation after transient MCA occlusion suggest that apoptosis contributes to the development of ischemic infarct and suggests that apoptotic isChemic brain damage is a dynamic ongoing process.
Abstract: We measured the temporal profile and anatomic distribution of cells exhibiting DNA fragmentation at various durations of reperfusion after middle cerebral artery (MCA) occlusion in the rat. Focal cerebral ischemia was induced in male Wistar rats (n = 62) using an intraluminal monofilament blockade of the MCA. After 2 h of MCA occlusion, the animals were killed at different durations of reperfusion (0.5, 3, 6, 9, and 12 h and 1, 2, 4, 7, 14, 21, and 28 days, n = 4 per time point). Sham-operated rats (n = 4) and normal rats not subjected to any surgical procedure (n = 4) were used as controls. Coronal brain sections (5 microns) were analyzed, using an in situ ApopTag kit, hematoxylin and eosin, and immunohistochemical double-staining methods. Six rats subjected to 2 h of MCA occlusion were killed at 24 h for measurement of DNA fragmentation by gel electrophoresis. Our data indicate that within a coronal section, DNA fragmentation was present in zero to three cells in each hemisphere of normal and sham-operated rats as well as in the contralateral hemisphere of ischemic rats. The number of cells exhibiting DNA fragmentation increased as early as 0.5 h (8 +/- 6), peaked at 24-48 h (213 +/- 59), and persisted for 4 weeks (10 +/- 2) after onset of reperfusion (p 95% neurons) were located primarily in the inner boundary zone of the infarct. With use of gel electrophoresis, purified DNA obtained from the ischemic tissue exhibited the characteristic nucleosome ladder pattern associated with apoptosis.(ABSTRACT TRUNCATED AT 250 WORDS)

483 citations

Journal ArticleDOI
TL;DR: The paper presents the control design for antilock braking systems via the sliding mode approach and considers the friction force as an output of the dynamic system which includes mechanical motion equations and the hydraulic circuit equations.
Abstract: The paper presents the control design for antilock braking systems via the sliding mode approach. In this study the authors formulate the problem as that of extremum searching in a highly uncertain situation. The authors consider the friction force as an output of the dynamic system which includes mechanical motion equations and the hydraulic circuit equations. This setting is complicated by the optimized function being a priori unknown, and the input (slip) not being measurable. >

480 citations

Journal ArticleDOI
TL;DR: In this paper, a spatially homogeneous rate theory was developed to describe the time rate of change of the radius of a spherical particle embedded in a configurationally random array of particles of like nature but differing sizes.

478 citations

Journal ArticleDOI
TL;DR: The data suggest that formation of new blood vessels in the adult brain after stroke is not restricted to angiogenesis but also involves vasculogenesis and that circulating endothelial progenitor cells from bone marrow contribute to the vascular substructure of the choroid plexus.
Abstract: We investigated whether circulating endothelial progenitor cells contribute to neovascularization after stroke. Donor bone marrow cells obtained from transgenic mice constitutively expressing beta-galactosidase transcriptionally regulated by an endothelial-specific promoter, Tie2, were injected into adult mice. Focal cerebral ischemia was induced by embolic middle cerebral artery (MCA) occlusion and changes of cerebral blood flow (CBF) were measured by perfusion-weighted magnetic resonance imaging (MRI). Laser scanning confocal microscopy (LSCM), immunohistochemistry and X-gal staining were performed. Perfusion-weighted MRI demonstrated increases in CBF around the boundary of an infarct area 1 month after ischemia. Morphological and 3-dimensional image analyses revealed enlarged and thin-walled blood vessels with sprouting or intussusception at the boundary of the ischemic lesion, which closely corresponded to elevated CBF areas detected on perfusion-weighted MRI, indicating the presence of neovascularization. X-gal and double immunostaining demonstrated that Tie2-lacZ-positive cells incorporated into sites of neovascularization at the border of the infarct, and these cells exhibited an endothelial antigenic marker (von Willebrand factor). In addition, bone marrow recipient mice without ischemia showed incorporation of Tie2-lacZ-expressing cells into vessels of the choroid plexus. These data suggest that formation of new blood vessels in the adult brain after stroke is not restricted to angiogenesis but also involves vasculogenesis and that circulating endothelial progenitor cells from bone marrow contribute to the vascular substructure of the choroid plexus.

477 citations


Authors

Showing all 36140 results

NameH-indexPapersCitations
Anil K. Jain1831016192151
Markus Antonietti1761068127235
Christopher M. Dobson1501008105475
Jack Hirsh14673486332
Galen D. Stucky144958101796
Federico Capasso134118976957
Peter Stone130122979713
Gerald R. Crabtree12837160973
Douglas A. Lauffenburger12270555326
Abass Alavi113129856672
Mark E. Davis11356855334
Keith Beven11051461705
Naomi Breslau10725442029
Fei Wang107182453587
Jun Yang107209055257
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202237
2021766
20201,397
20192,195
20181,945
20171,995