Institution
Forensic Science Service
About: Forensic Science Service is a based out in . It is known for research contribution in the topics: Population & DNA profiling. The organization has 573 authors who have published 599 publications receiving 27149 citations.
Topics: Population, DNA profiling, STR multiplex system, Crime scene, High-performance liquid chromatography
Papers published on a yearly basis
Papers
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TL;DR: It is shown that this technique can be used for forensic purposes; DNA of high relative molecular mass (Mr) can be isolated from 4-yr-old bloodstains and semen stains made on cotton cloth and digested to produce DNA fingerprints suitable for individual identification.
Abstract: Many highly polymorphic minisatellite loci can be detected simultaneously in the human genome by hybridization to probes consisting of tandem repeats of the 'core' sequence. The resulting DNA fingerprints produced by Southern blot hybridization are comprised of multiple hypervariable DNA fragments, show somatic and germline stability and are completely specific to an individual. We now show that this technique can be used for forensic purposes; DNA of high relative molecular mass (Mr) can be isolated from 4-yr-old bloodstains and semen stains made on cotton cloth and digested to produce DNA fingerprints suitable for individual identification. Further, sperm nuclei can be separated from vaginal cellular debris, obtained from semen-contaminated vaginal swabs, enabling positive identification of the male donor/suspect. It is envisaged that DNA fingerprinting will revolutionize forensic biology particularly with regard to the identification of rape suspects.
1,020 citations
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TL;DR: In this paper, the authors developed and explored the feasibility of the use of a nine-category matrix of harm, with an expert delphic procedure, to assess the harms of a range of illicit drugs in an evidence-based fashion.
1,018 citations
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TL;DR: It is demonstrated that an apparent mis-match between crime-stain and a suspect DNA profile does not necessarily result in an exclusion, and the duplication guideline is robust by applying a statistical theory that models three key parameters - namely the incidence of allele drop-out, laboratory contamination and stutter.
609 citations
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TL;DR: The DNA evidence supports the hypothesis that the remains of the last Tsar, Tsarina, three of their five children, the Royal Physician and three servants are those of the Romanov family.
Abstract: Nine skeletons found in a shallow grave in Ekaterinburg, Russia, in July 1991, were tentatively identified by Russian forensic authorities as the remains of the last Tsar, Tsarina, three of their five children, the Royal Physician and three servants. We have performed DNA based sex testing and short tandem repeat (STR) analysis and confirm that a family group was present in the grave. Analysis of mitochondrial (mt) DNA reveals an exact sequence match between the putative Tsarina and the three children with a living maternal relative. Amplified mtDNA extracted from the remains of the putative Tsar has been cloned to demonstrate heteroplasmy at a single base within the mtDNA control region. One of these sequences matches two living maternal relatives of the Tsar. We conclude that the DNA evidence supports the hypothesis that the remains are those of the Romanov family.
601 citations
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TL;DR: Quantitation enables sex chromosome aneuploidy to be determined, and the amelogenin intron sequence can also be co-amplified with several highly polymorphic microsatellite loci, thereby providing a combined gender/identity DNA test.
Abstract: A rapid, simple and reliable sex test that entails PCR amplification of a segment of the X-Y homologous gene amelogenin has been developed. We used a single pair of primers spanning part of the first intron which generated 106-bp and 112-bp PCR products from the X and Y homologues, respectively, that can be analyzed simply by agarose gel electrophoresis. Less than 1 ng of template DNA is required for gender assignment, and the test has been automated by the fluorescent tagging of the PCR products that are then quantitated during electrophoresis by automated fluorescence-detection technology. Quantitation enables sex chromosome aneuploidy to be determined, and the amelogenin intron sequence can also be co-amplified with several highly polymorphic microsatellite loci, thereby providing a combined gender/identity DNA test.
551 citations
Authors
Showing all 573 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peter B. Jones | 145 | 1857 | 94641 |
Peter Gill | 89 | 502 | 35160 |
Angel Carracedo | 88 | 885 | 38053 |
Bruce S. Weir | 81 | 257 | 62156 |
David M. Ward | 73 | 205 | 17273 |
Walther Parson | 72 | 415 | 18336 |
Niels Morling | 59 | 457 | 14268 |
Vincent Marks | 52 | 332 | 10947 |
Graham S. Jackson | 47 | 107 | 7396 |
John Buckleton | 42 | 235 | 6800 |
Ian W. Evett | 41 | 108 | 5038 |
Christophe Champod | 37 | 150 | 4319 |
Jon C. Cole | 36 | 139 | 4435 |
Harry Sumnall | 33 | 136 | 3634 |
Frederic Zenhausern | 31 | 126 | 3857 |