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Institution

Fred Hutchinson Cancer Research Center

NonprofitCape Town, South Africa
About: Fred Hutchinson Cancer Research Center is a nonprofit organization based out in Cape Town, South Africa. It is known for research contribution in the topics: Population & Transplantation. The organization has 12322 authors who have published 30954 publications receiving 2288772 citations. The organization is also known as: Fred Hutch & The Hutch.


Papers
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Journal ArticleDOI
07 Oct 1993-Nature
TL;DR: The 2.5 Å crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity.
Abstract: The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.

984 citations

Journal ArticleDOI
Mark Gerstein1, Zhi John Lu1, Eric L. Van Nostrand2, Chao Cheng1, Bradley I. Arshinoff3, Tao Liu4, Kevin Y. Yip1, R. Robilotto1, Andreas Rechtsteiner5, Kohta Ikegami6, P. Alves1, A. Chateigner, Marc D. Perry7, Mitzi Morris8, Raymond K. Auerbach1, X. Feng9, Jing Leng1, A. Vielle10, Wei Niu1, Kahn Rhrissorrakrai8, Ashish Agarwal1, Roger P. Alexander1, Galt P. Barber5, Cathleen M. Brdlik2, J. Brennan6, Jeremy Brouillet2, Adrian Carr, Ming Sin Cheung10, Hiram Clawson5, Sergio Contrino, Luke Dannenberg11, Abby F. Dernburg12, Arshad Desai13, L. Dick14, Andréa C. Dosé12, Jiang Du1, Thea A. Egelhofer5, Sevinc Ercan6, Ghia Euskirchen1, Brent Ewing15, Elise A. Feingold16, Reto Gassmann13, Peter J. Good16, Philip Green15, Francois Gullier, M. Gutwein8, Mark S. Guyer16, Lukas Habegger1, Ting Han17, Jorja G. Henikoff18, Stefan R. Henz19, Angie S. Hinrichs5, H. Holster11, Tony Hyman19, A. Leo Iniguez11, J. Janette1, M. Jensen6, Masaomi Kato1, W. James Kent5, E. Kephart7, Vishal Khivansara17, Ekta Khurana1, John Kim17, P. Kolasinska-Zwierz10, Eric C. Lai20, Isabel J. Latorre10, Amber Leahey15, Suzanna E. Lewis12, Paul Lloyd7, Lucas Lochovsky1, Rebecca F. Lowdon16, Yaniv Lubling21, Rachel Lyne, Michael J. MacCoss15, Sebastian D. Mackowiak22, Marco Mangone8, Sheldon J. McKay23, D. Mecenas8, Gennifer E. Merrihew15, David M. Miller24, A. Muroyama13, John I. Murray15, Siew Loon Ooi18, Hoang Pham12, T. Phippen5, Elicia Preston15, Nikolaus Rajewsky22, Gunnar Rätsch19, Heidi Rosenbaum11, Joel Rozowsky1, Kim Rutherford, P. Ruzanov7, Mihail Sarov19, Rajkumar Sasidharan1, Andrea Sboner1, P. Scheid8, Eran Segal21, Hyunjin Shin4, C. Shou1, Frank J. Slack1, C. Slightam2, Richard J.H. Smith, William C. Spencer24, Eo Stinson12, S. Taing4, Teruaki Takasaki5, D. Vafeados15, Ksenia Voronina13, Guilin Wang1, Nicole L. Washington12, Christina M. Whittle6, Beijing Wu2, Koon-Kiu Yan1, Georg Zeller, Z. Zha7, Mei Zhong1, Xingliang Zhou6, Julie Ahringer10, Susan Strome5, Kristin C. Gunsalus25, Gos Micklem, X. Shirley Liu4, Valerie Reinke1, Stuart K. Kim2, LaDeana W. Hillier15, Steven Henikoff18, Fabio Piano25, Michael Snyder1, Lincoln Stein23, Jason D. Lieb6, Robert H. Waterston15 
24 Dec 2010-Science
TL;DR: These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes.
Abstract: We systematically generated large-scale data sets to improve genome annotation for the nematode Caenorhabditis elegans, a key model organism. These data sets include transcriptome profiling across a developmental time course, genome-wide identification of transcription factor-binding sites, and maps of chromatin organization. From this, we created more complete and accurate gene models, including alternative splice forms and candidate noncoding RNAs. We constructed hierarchical networks of transcription factor-binding and microRNA interactions and discovered chromosomal locations bound by an unusually large number of transcription factors. Different patterns of chromatin composition and histone modification were revealed between chromosome arms and centers, with similarly prominent differences between autosomes and the X chromosome. Integrating data types, we built statistical models relating chromatin, transcription factor binding, and gene expression. Overall, our analyses ascribed putative functions to most of the conserved genome.

978 citations

Journal ArticleDOI
TL;DR: Comparison of WHI FFQ nutrient intake measures to independent and unbiased measures, such as doubly labeled water estimates of energy expenditure, are needed to help address the validity of the FFQ in this population.

978 citations

Journal ArticleDOI
26 Mar 1997-JAMA
TL;DR: It is recommended that individuals considering genetic testing be counseled regarding the unknown efficacy of measures to reduce risk and that care for individuals with cancer-predisposing mutations be provided whenever possible within the context of research protocols designed to evaluate clinical outcomes.
Abstract: Objective. —To provide recommendations for cancer surveillance and risk reduction for individuals carrying mutations in the BRCA1 or BRCA2 genes. Participants. —A task force with expertise in medical genetics, oncology, primary care, gastroenterology, and epidemiology convened by the Cancer Genetics Studies Consortium (CGSC), organized by National Human Genome Research Institute (previously the National Center for Human Genome Research). Evidence. —Studies evaluating cancer risk, surveillance, and risk reduction in individuals genetically susceptible to breast and ovarian cancer were identified using MEDLINE (National Library of Medicine) and from bibliographies of articles thus identified. Indexing terms used were "genetics" in combination with "breast cancer," "ovarian cancer," and "screening," or "surveillance" in combination with "cancer family" and " BRCA1 " and " BRCA2 ." For studies evaluating specific interventions, quality of evidence was assessed using criteria of the US Preventive Services Task Force. Consensus Process. —The task force developed recommendations through discussions over a 14-month period. Conclusions. —Efficacy of cancer surveillance or other measures to reduce risk in individuals who carry cancer-predisposing mutations is unknown. Based on expert opinion concerning presumptive benefit, early breast cancer and ovarian cancer screening are recommended for individuals with BRCA1 mutations and early breast cancer screening for those with BRCA2 mutations. No recommendation is made for or against prophylactic surgery (eg, mastectomy, oophorectomy); these surgeries are an option for mutation carriers, but evidence of benefit is lacking, and case reports have documented the occurrence of cancer following prophylactic surgery. It is recommended that individuals considering genetic testing be counseled regarding the unknown efficacy of measures to reduce risk and that care for individuals with cancer-predisposing mutations be provided whenever possible within the context of research protocols designed to evaluate clinical outcomes.

977 citations

Journal ArticleDOI
TL;DR: Structural and functional aspects of FBW7, the substrate recognition component of an evolutionary conserved SCF, and its role in the development of cancer are focused on.
Abstract: FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies. Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis. This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer.

974 citations


Authors

Showing all 12368 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
Robert Langer2812324326306
Meir J. Stampfer2771414283776
JoAnn E. Manson2701819258509
David J. Hunter2131836207050
Peer Bork206697245427
Eric Boerwinkle1831321170971
Ruedi Aebersold182879141881
Bruce M. Psaty1811205138244
Aaron R. Folsom1811118134044
David Baker1731226109377
Frederick W. Alt17157795573
Lily Yeh Jan16246773655
Yuh Nung Jan16246074818
Charles N. Serhan15872884810
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20237
202275
20211,981
20201,995
20191,685
20181,571