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Institution

French Institute of Health and Medical Research

GovernmentParis, France
About: French Institute of Health and Medical Research is a government organization based out in Paris, France. It is known for research contribution in the topics: Population & Receptor. The organization has 109367 authors who have published 174236 publications receiving 8365503 citations.


Papers
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Journal ArticleDOI
17 Mar 2004-Gene
TL;DR: Two different modes of regulation reveal unexpected levels of complexity in the dynamics of retinoid-dependent transcription: phosphorylation and ubiquitin-proteasome.

749 citations

Journal ArticleDOI
TL;DR: In patients with stable coronary artery disease and left-ventricular systolic dysfunction, elevated heart rate (70 bpm or greater) identifies those at increased risk of cardiovascular outcomes, with a differential effect on outcomesassociated with heart failure and outcomes associated with coronary events.

749 citations

Journal ArticleDOI
01 Aug 1997-Diabetes
TL;DR: Obesity is not associated with alteration in PPAR gene expression in abdominal subcutaneous adipose tissue in humans, indicating that improvement of insulin resistance with thiazolidinediones may not result from a direct effect of these agents on PPARγ in muscle.
Abstract: Members of the peroxisome proliferator-activated receptor (PPAR) family might be involved in pathologies with altered lipid metabolism. They participate in the control of the expression of genes involved in lipid metabolism and adipocyte differentiation. In addition, thiazolidinediones improve insulin resistance in vivo by activating PPAR gamma. However, little is known regarding their tissue distribution and relative expression in humans. Using a quantitative and sensitive reverse transcription (RT)-competitive polymerase chain reaction (PCR) assay, we determined the distribution and relative mRNA expression of the four PPARs (alpha,beta, gamma1, and gamma2) and liver X receptor-alpha (LXR alpha) in the main tissues implicated in lipid metabolism. PPAR alpha and LXR alpha were mainly expressed in liver, while PPAR gamma1 predominated in adipose tissue and large intestine. We found that PPAR gamma2 mRNA was a minor isoform, even in adipose tissue, thus causing question of its role in humans. PPAR beta mRNA was present in all the tissues tested at low levels. In addition, PPAR gamma mRNA was barely detectable in skeletal muscle, suggesting that improvement of insulin resistance with thiazolidinediones may not result from a direct effect of these agents on PPAR gamma in muscle. Obesity and NIDDM were not associated with change in PPARs and LXR alpha expression in adipose tissue. The mRNA levels of PPAR gamma1, the predominant form in adipocytes, did not correlate with BMI, leptin mRNA levels, or fasting insulinemia in 29 subjects with various degrees of obesity. These results indicated that obesity is not associated with alteration in PPAR gene expression in abdominal subcutaneous adipose tissue in humans.

749 citations

Journal ArticleDOI
31 Jan 2002-Neuron
TL;DR: Human homologs of the monkey areas AIP, MIP, V6A, and LIP are suggested and imply a large cortical expansion of the inferior parietal lobule correlated with the development of human language and calculation abilities.

749 citations

Journal ArticleDOI
22 Mar 1991-Cell
TL;DR: There is competition between the cells and that the N protein is required for the mechanism whereby the cells choose between alternative fates, which suggests that N acts as a receptor for an inhibitory signal emanating from the neural precursors.

748 citations


Authors

Showing all 109539 results

NameH-indexPapersCitations
Guido Kroemer2361404246571
Pierre Chambon211884161565
Peer Bork206697245427
Ronald M. Evans199708166722
Raymond J. Dolan196919138540
Matthew Meyerson194553243726
Charles A. Dinarello1901058139668
Julie E. Buring186950132967
Tadamitsu Kishimoto1811067130860
Didier Raoult1733267153016
Giuseppe Remuzzi1721226160440
Zena Werb168473122629
Nahum Sonenberg167647104053
Philippe Froguel166820118816
Gordon J. Freeman164579105193
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202368
2022306
20217,549
20207,367
20196,969
20186,607