Institution
Fu Jen Catholic University
Education•Taipei, Taiwan•
About: Fu Jen Catholic University is a education organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 6842 authors who have published 9512 publications receiving 171005 citations. The organization is also known as: FJU & Fu Jen.
Topics: Population, Hazard ratio, Cohort study, Cancer, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: This proof-of-concept study provides a simple way to combine current O2 -dependent cancer therapy of PDT to overcome cancer cell hypoxia, thus achieving more effective anticancer treatments.
Abstract: Photodynamic therapy (PDT) typically involves oxygen (O2 ) consumption and therefore suffers from greatly limited anticancer therapeutic efficacy in tumor hypoxia. Here, it is reported for the first time that amine-terminated, PAMAM dendrimer-encapsulated gold nanoclusters (AuNCs-NH2 ) can produce O2 for PDT via their intrinsic catalase-like activity. The AuNCs-NH2 not only show optimum H2 O2 consumption via the catalase-like activity over the physiological pH range (i.e., pH 4.8-7.4), but also extend such activity to acidic conditions. The possible mechanism is deduced from that the enriched tertiary amines of dendrimers are easily protonated in acidic solutions to facilitate the preadsorption of OH on the metal surface, thereby favorably triggering the catalase-like reaction. By taking advantage of the exciting feature on AuNCs-NH2 , the possibility to supply O2 via the catalase-like activity of AuNCs-NH2 for PDT against hypoxia of cancer cells was further studied. This proof-of-concept study provides a simple way to combine current O2 -dependent cancer therapy of PDT to overcome cancer cell hypoxia, thus achieving more effective anticancer treatments.
191 citations
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TL;DR: In this paper, the pion transition form factor, F(Q(2)), is measured for the kinematical region 4 GeV2 <= Q(2) <= 40 GeV 2, where -Q 2 is the invariant-mass squared of a virtual photon.
Abstract: We report a measurement of the process gamma gamma* -> pi(0) with a 759 fb(-1) data sample recorded with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider. The pion transition form factor, F(Q(2)), is measured for the kinematical region 4 GeV2 <= Q(2) <= 40 GeV2, where -Q(2) is the invariant-mass squared of a virtual photon. The measured values of Q(2)vertical bar F(Q(2))vertical bar agree well with the previous measurements below Q(2) similar or equal to 9 GeV2 but do not exhibit the rapid growth in the higher Q(2) region seen in another recent measurement, which exceeds the asymptotic QCD expectation by as much as 50%.
190 citations
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TL;DR: In this article, the location of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation (PAF) can be predicted by both gender and left atrial enlargement.
189 citations
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TL;DR: The results suggest that leptin may have an independent role in breast tumorigenesis and more research is needed to elucidate molecular mechanisms and local leptin levels that are critical for the development of breast cancers.
Abstract: The present case–control study was to investigate the relationships of plasma leptin level and anthropometric measures of adiposity with the risk of breast cancer. Questionnaire information, anthropometric measures and blood samples were taken before treatment from 297 incident cases with breast cancer and 593 controls admitted for health examination at the Tri-Service General Hospital, Taipei, between 2004 and 2006. Plasma levels of leptin were measured by RIA. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for assessing the associations. Overall, higher leptin concentrations were significantly associated with an increased risk of breast cancer (OR (95% CI) for top vs bottom tertile of leptin was 1.63 (1.07–2.49), Ptrend=0.009). Waist circumference was a significant anthropometric factor for breast cancer in both pre- and postmenopausal women. Furthermore, the associations of leptin with breast cancer risk remained after adjustment for obesity indices. These results suggest that leptin may have an independent role in breast tumorigenesis. Regardless of the impact of circulating leptin, more research is needed to elucidate molecular mechanisms and local leptin levels that are critical for the development of breast cancers.
189 citations
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TL;DR: It is concluded that riluzole exerts their presynaptic inhibition, likely through a reduction in the calcium influx mediated by P/Q-type calcium channels, and thereby inhibits the release of glutamate from rat cerebrocortical nerve terminals.
187 citations
Authors
Showing all 6861 results
Name | H-index | Papers | Citations |
---|---|---|---|
P. Chang | 170 | 2154 | 151783 |
Christian Guilleminault | 133 | 897 | 68844 |
Pan-Chyr Yang | 102 | 786 | 46731 |
Po-Ren Hsueh | 92 | 1030 | 38811 |
Shyi-Ming Chen | 90 | 425 | 22172 |
Peter J. Rossky | 74 | 280 | 21183 |
Chong-Jen Yu | 72 | 577 | 22940 |
Shuu Jiun Wang | 71 | 502 | 24800 |
Jaw-Town Lin | 67 | 434 | 15482 |
Lung Chi Chen | 63 | 267 | 13929 |
Ronald E. Taam | 59 | 290 | 12383 |
Jiann T. Lin | 58 | 190 | 10801 |
Yueh-Hsiung Kuo | 57 | 618 | 12204 |
San Lin You | 55 | 178 | 16572 |
Liang-Gee Chen | 54 | 582 | 12073 |