Institution
Fu Jen Catholic University
Education•Taipei, Taiwan•
About: Fu Jen Catholic University is a education organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 6842 authors who have published 9512 publications receiving 171005 citations. The organization is also known as: FJU & Fu Jen.
Topics: Population, Hazard ratio, Cohort study, Cancer, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: The results suggest that fluvastatin and lovastatin induce neuroglial differentiation of human MSCs and that these cholesterol‐lowering agents might be used in conjunction with MSC transplantation in the future for treating neurological disorders and injuries.
Abstract: Recent studies have shown that statins, the most potent inhibitors of 3-hydroxy-2-methylglutaryl coenzyme A (HMG-CoA) reductase, stimulate bone formation in vitro and in rodents by activating the expression of bone morphogenetic protein-2 (BMP-2), one of the most critical osteoblast differentiation-inducing factors. However, the effect of statins on mesenchymal stem cells (MSCs) is yet to be reported. The purpose of this study is to investigate the influence of fluvastatin, lovastatin, and pravastatin, three commonly prescribed lipid-lowering agents, on the proliferation and differentiation of human MSCs. To our surprise, even though fluvastatin and lovastatin effectively suppressed the growth of human MSCs, a neuroglia rather than osteoblast-like morphology was observed after treatment. Interestingly, such morphological change was inhibited by the co-addition of geranylgeranyl pyrophosphate (GGPP). Immunofluorescence staining with antibodies against neuron-, astrocyte-, as well as oligodendrocyte-specific markers confirmed the neuroglial identity of the differentiated cells. However, BMP-2 is unlikely to play a positive role in neuroglial differentiation of MSCs since its expression was down-regulated in fluvastatin-treated cells. Taken together, our results suggest that fluvastatin and lovastatin induce neuroglial differentiation of human MSCs and that these cholesterol-lowering agents might be used in conjunction with MSC transplantation in the future for treating neurological disorders and injuries.
54 citations
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TL;DR: Results showed that SAH increased Abeta protein formation in a concentration-dependent manner, and this effect of SAH was accompanied by significantly increased expression of APP and PS1 proteins, although SAH only significantly increased the expression of BACE1 at the highest concentration used
Abstract: S-Adenosylhomocysteine (SAH) has been implicated as a risk factor for neurodegenerative diseases such as Alzheimer's disease. As SAH is a potent inhibitor of all cellular methyltransferases, we herein examined the hypothesis that SAH may increase the formation of amyloid β-peptide (Aβ) in BV-2 mouse microglial cells through hypomethylation of presenilin 1 protein (PS1) and β-site amyloid precursor protein cleaving enzyme 1 (BACE1), both of which cleave Aβ precursor protein (APP) to form Aβ. The results showed that SAH increased Aβ protein formation in a concentration-dependent manner (10–500 nM), and this effect of SAH was accompanied by significantly increased expression of APP and PS1 proteins, although SAH only significantly increased the expression of BACE1 at the highest concentration used (500 nM). SAH (500 nM) markedly induced hypomethylation of APP and PS1 gene promoters. Incubation of cells with 5′-azc (20 μM), also an inhibitor of DNA methyltransferases enhanced Aβ protein expression and APP and PS1 gene promoters hypomethylation. By contrast, pre-incubation of cells with betaine (1.0 mM), 30 min followed by incubation with SAH (500 nM) or 5′-azc (20 μM) for 24 h markedly prevented the expression of Aβ protein (by 50%, P
54 citations
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TL;DR: It is revealed that chronic HCV infection is associated with an increased risk of developing ESRD and suggests that elevated serum levels of HCV RNA (>167,000 IU/mL) and HCV genotype 1 are strong predictors of ESRd, indicating clinical implications for the management of chronicHCV.
54 citations
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TL;DR: To date, there is no cost-effective strategy for an average-risk individual from a population with low incidence of GC, and therefore screening is unwarranted and cannot be recommended for them.
54 citations
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TL;DR: This is the first report establishing drug permeation profiles for UV-irradiated skin that depends on the UV wavelength, irradiated energy, and physicochemical properties of the permeant.
54 citations
Authors
Showing all 6861 results
Name | H-index | Papers | Citations |
---|---|---|---|
P. Chang | 170 | 2154 | 151783 |
Christian Guilleminault | 133 | 897 | 68844 |
Pan-Chyr Yang | 102 | 786 | 46731 |
Po-Ren Hsueh | 92 | 1030 | 38811 |
Shyi-Ming Chen | 90 | 425 | 22172 |
Peter J. Rossky | 74 | 280 | 21183 |
Chong-Jen Yu | 72 | 577 | 22940 |
Shuu Jiun Wang | 71 | 502 | 24800 |
Jaw-Town Lin | 67 | 434 | 15482 |
Lung Chi Chen | 63 | 267 | 13929 |
Ronald E. Taam | 59 | 290 | 12383 |
Jiann T. Lin | 58 | 190 | 10801 |
Yueh-Hsiung Kuo | 57 | 618 | 12204 |
San Lin You | 55 | 178 | 16572 |
Liang-Gee Chen | 54 | 582 | 12073 |