Institution
Fu Jen Catholic University
Education•Taipei, Taiwan•
About: Fu Jen Catholic University is a education organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 6842 authors who have published 9512 publications receiving 171005 citations. The organization is also known as: FJU & Fu Jen.
Topics: Population, Hazard ratio, Cohort study, Cancer, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: BAF1 exposure contributes to the development of HCC in participants with significant risk factors for cirrhosis including alcohol and HCV infection, and remained an independent risk predictor for HCV-related HCC after adjustment for other HCC predictors.
52 citations
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TL;DR: Results of this study demonstrate that stock cost and machine idle cost are inversely related to the number of lots split and have marginal decreasing result of benefit.
52 citations
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TL;DR: PGA-SPIONs modified with an edible biopolymer poly(γ-glutamic acid) (PGA) were synthesized by coprecipitation method and evaluated for their removal efficiency of heavy metals from a metal solution, and simulated gastrointestinal fluid (SGIF).
Abstract: Background:
Chelation therapy involving organic chelators for treatment of heavy metal intoxication can cause cardiac arrest, kidney overload, mineral deficiency, and anemia.
52 citations
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TL;DR: The results suggest that nicotine exerts its potentiatory effect presynaptically, likely through the activation of α7 nicotinic receptors, resulting in Na+ influx and local depolarization, which subsequently enhances the CaK+ entry through voltage‐dependent N‐and P/Q‐type Ca2+ channels as well as the vesicular release machinery to cause an increase in evoked glutamate release from rat prefrontocortical nerve terminals.
Abstract: The effect of nicotine on evoked glutamate release from isolated nerve terminals (synaptosomes) from rat prefrontal cortex was examined. We found that nicotine significantly potentiated 4-aminopyridine (4AP)-evoked glutamate release, and this potentiatory effect was mimicked by the selective α7 nicotinic receptor agonist choline and was blocked by the selective α7 nicotinic receptor antagonist methyllycaconitine, indicating its mediation by α7 nicotinic receptors. Examination of the effect of nicotine on cytosolic [Ca2+] revealed that the potentiation of glutamate release was associated with an increase in voltage-dependent Ca2+ influx through N- and P/Q-type Ca2+ channels. The potentiatory effect of nicotine on Ca2+ influx seems to be attributed to its increasing synaptosomal excitability because nicotine significantly increased depolarization-evoked increase in the intrasynaptosomal free Na+ concentration and 4AP-evoked depolarization of the synaptosomal plasma membrane potential. Also, Ca2+ ionophore ionomycin-induced glutamate release was enhanced by nicotine, and this action was blocked by methyllycaconitine. These results suggest that nicotine exerts its potentiatory effect presynaptically, likely through the activation of α7 nicotinic receptors, resulting in Na+ influx and local depolarization, which subsequently enhances the CaK+ entry through voltage-dependent N-and P/Q-type Ca2+ channels as well as the vesicular release machinery to cause an increase in evoked glutamate release from rat prefrontocortical nerve terminals. Moreover, in this release potentiation may involve an activation of Ca2+/calmodulin signaling pathway as nicotine-mediated potentiation of 4AP- and ionomycin-evoked glutamate release were significantly attenuated by KN62, a selective inhibitor of Ca2+/calmodulin-dependent kinase II. Synapse 59:491–501, 2006. © 2006 Wiley-Liss, Inc.
52 citations
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TL;DR: The results suggest an important role of cSLNs in governing the activation of human neutrophils and the cytotoxicity, pro-inflammatory mediators, Ca(2+) mobilization, mitogen-activated protein kinases (MAPKs), and neutrophil extracellular traps (NETs) as the indicators of PMN stimulation were examined.
52 citations
Authors
Showing all 6861 results
Name | H-index | Papers | Citations |
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P. Chang | 170 | 2154 | 151783 |
Christian Guilleminault | 133 | 897 | 68844 |
Pan-Chyr Yang | 102 | 786 | 46731 |
Po-Ren Hsueh | 92 | 1030 | 38811 |
Shyi-Ming Chen | 90 | 425 | 22172 |
Peter J. Rossky | 74 | 280 | 21183 |
Chong-Jen Yu | 72 | 577 | 22940 |
Shuu Jiun Wang | 71 | 502 | 24800 |
Jaw-Town Lin | 67 | 434 | 15482 |
Lung Chi Chen | 63 | 267 | 13929 |
Ronald E. Taam | 59 | 290 | 12383 |
Jiann T. Lin | 58 | 190 | 10801 |
Yueh-Hsiung Kuo | 57 | 618 | 12204 |
San Lin You | 55 | 178 | 16572 |
Liang-Gee Chen | 54 | 582 | 12073 |