Fu Jen Catholic University

About: Fu Jen Catholic University is a education organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 6842 authors who have published 9512 publications receiving 171005 citations. The organization is also known as: FJU & Fu Jen.

A tetrazolato-bridged dinuclear platinum(II) complex exhibits markedly high in vivo antitumor activity against pancreatic cancer.

Abstract: Some platinum(II) coordination complexes are effective anticancer agents. cis-Diamminedichloridoplatinum(II) (cisplatin), a mononuclear platinum(II) complex, is one of the most commonly used anticancer drugs. Although platinum-based chemotherapy can cause serious side effects, its efficacy has prompted the design and synthesis of next-generation anticancer platinum(II) drugs which are effective against cancers that are typically resistant to chemotherapy, such as lung cancer, pancreatic cancer, and platinum-refractory cancer. 3] Lung cancer is the leading cause of cancer deaths worldwide, and non-small-cell lung cancer (NSCLC) accounts for 80 % of lung cancers. Pancreatic cancer remains the fourth leading cause of cancer-related deaths in the United States. Clinical platinum-based drugs show antitumor efficacy by forming Pt–DNA adducts. We and others have reported that azolato-bridged dinuclear Pt complexes such as [{cis-Pt(NH3)2}2(m-OH)(m-pyrazolato)](NO3)2 (1) and [{cis-Pt(NH3)2}2(mOH)(m-1,2,3-triazolato-N1,N2)](NO3)2 (2), interact with DNA through a mechanism different from that of cisplatin and exhibit much higher in vitro cytotoxicity than cisplatin. The chemical structures of 1 and 2 are shown in Figure 1. To further expand drug discovery, we designed two new tetrazolatobridged complexes, [{cis-Pt(NH3)2}2(m-OH)(m-tetrazolatoN1,N2)](ClO4)2 (3) and [{cis-Pt(NH3)2}2(m-OH)(m-tetrazolatoN2,N3)](ClO4)2 (4), which are structural isomers (Figure 1). Herein we report their synthesis, characterization, in vitro cytotoxicity, and preliminary in vivo antitumor efficacy. Complexes 3 and 4 were synthesized by using a modified protocol for azolato-bridged complexes, as previously described (Scheme 1). A slight excess of tetrazole was added to an aqueous solution of the starting material, [cis-Pt(NH3)2(mOH)]2(NO3)2, which was then incubated at 40 8C in the dark to yield 3 and 4 at a molar ratio of 6.5:3.5 (see Supporting Information). This preparation ratio likely resulted from the higher nucleophilicity of N1 or N4 bound to one carbon and one nitrogen atom, compared with N2 or N3 bound to two nitrogen atoms. The two structural isomers were separated and purified by reversed-phase liquid chromatography and characterized by H, C, and Pt NMR spectroscopy and ESI mass spectrometry. For 3, two Pt NMR chemical shifts appeared at 2127 and 2177 ppm, reflecting two slightly different Pt[N3O] environments, because the tetrazolato bridge is arranged in an asymmetric fashion; there is N1,N2 coordination of Pt atoms. In contrast, for 4, a single Pt NMR chemical shift appears at about 2180 ppm, confirming the Pt[N3O] environment and the symmetric structure of the complexes on the tetrazolato bridge; there is N2,N3 coordination of Pt atoms. We tested the cytotoxicity of our azolato-bridged dinuclear Pt complexes, along with cisplatin for comparison, on the H460 human NSCLC cell line; the IC50 values are listed in Table 1. Complex 1 showed no activity at concentrations Figure 1. Structures of (1) [{cis-Pt(NH3)2}2(m-OH)(m-pyrazolato-N1,N2)] 2 + , (2) [{cis-Pt(NH3)2}2(m-OH)(m-1,2,3-triazolato-N1,N2)] 2+ , (3) [{cis-Pt(NH3)2}2(m-OH)(mtetrazolato-N1,N2)] + , and (4) [{cis-Pt(NH3)2}2(m-OH)(m-tetrazolato-N2,N3)] 2 +

Measurement of the e+e-→J/ψcc̄ cross section at s 10.6GeV

Abstract: We present a new measurement of the e(+)e(-)-> J/psi c(c)over bar cross section where the c(c)over bar pair can fragment either into charmed hadrons or a charmonium state. In the former case the J/psi and a charmed hadron are reconstructed, while the latter process is measured using the recoil mass technique, which allows the identification of two-body final states without reconstruction of one of the charmonia. The measured e(+)e(-)-> J/psi c(c)over bar cross section is (0.74 +/- 0.08(-0.08)(+0.09)) pb, and the e(+)e(-)-> J/psi Xnon-c(c)over bar cross section is (0.43 +/- 0.09 +/- 0.09) pb. We note that the measured cross sections are obtained from a data sample with the multiplicity of charged tracks in the event larger than 4; corrections for the effect of this requirement are not performed as this cannot be done in a model-independent way. The analysis is based on a data sample with an integrated luminosity of 673 fb(-1) recorded near the Upsilon(4S) resonance with the Belle detector at the KEKB e(+)e(-) asymmetric-energy collider.

Various physicochemical and surface properties controlling the bioactivity of cerium oxide nanoparticles.

Abstract: Amidst numerous emerging nanoparticles, cerium oxide nanoparticles (CNPs) possess fascinating pharmacological potential as they can be used as a therapeutic for various oxidative stress-associated chronic diseases such as cancer, inflammation and neurodegeneration due to unique redox cycling between Ce3+ and Ce4+ oxidation states on their surface. Lattice defects generated by the formation of Ce3+ ions and compensation by oxygen vacancies on CNPs surface has led to switching between CeO2 and CeO2-x during redox reactions making CNPs a lucrative catalytic nanoparticle capable of mimicking key natural antioxidant enzymes such as superoxide dismutase and catalase. Eventually, most of the reactive oxygen species and nitrogen species in biological system are scavenged by CNPs via an auto-regenerative mechanism in which a minimum dose can exhibit catalytic activity for a longer duration. Due to the controversial outcomes on CNPs toxicity, considerable attention has recently been drawn towards establishing relationships between the physicochemical properties of CNPs obtained by different synthesis methods and biological effects ranging from toxicity to therapeutics. Unlike non-redox active nanoparticles, variations in physicochemical properties and the surface properties of CNPs obtained from different synthesis methods can significantly affect their biological activity (inactive, antioxidant, or pro-oxidant). Moreover, these properties can influence the biological identity, cellular interactions, cellular uptake, biodistribution, and therapeutic efficiency. This review aims to highlight the critical role of various physicochemical and the surface properties of CNPs controlling their biological activity based on 165 cited references.