Fu Jen Catholic University

About: Fu Jen Catholic University is a education organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 6842 authors who have published 9512 publications receiving 171005 citations. The organization is also known as: FJU & Fu Jen.

Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo.

Abstract: Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. We report herein a new and simple method to directly assemble a small hydrophobic anticancer drug, 10-hydroxycamptothecin (HCPT), with a photosensitizer chlorin e6 (Ce6) to form stable, discrete nanorods (NRs), which not only circumvent the extreme hydrophobicity of HCPT but also incorporate two different modalities into one delivery system for combination therapy. Different ratios of HCPT to Ce6 were evaluated to afford the optimal nanoformulation. The as-prepared HCPT/Ce6 NRs were fully characterized, indicating a relatively uniform size of about 360 nm in length and 135 nm in width, and a surface charge of about -33 mV. Efficient internalization of the NRs by cancer cells was observed by using a confocal microscope and the generation of singlet oxygen species arising from the NRs under 655 nm laser irradiation was detected by DCFH-DA. As a result, very potent in vitro efficacy against several kinds of cancer cell lines was achieved through chemo-photodynamic dual therapy. The in vivo tumor suppression effect of HCPT/Ce6 NRs was verified on a subcutaneous xenograft mouse model, achieving almost complete inhibition of the tumor growth, which may benefit from the superiority of nanomedicine and combination therapy. The rationale of this facile and green strategy for carrier-free nanodrug formulation via the self-assembly approach might provide new opportunities for the development of combinatorial therapeutics for tumors.

Predictive Equations for Basal Metabolic Rate in Chinese Adults: A Cross-Validation Study

Abstract: Objective To develop predictive equations for basal metabolic rate (BMR) in healthy Chinese adults and to evaluate factors that may influence BMR. Design Measuring the BMR of Chinese adults by indirect calorimetry. Selected subjects were randomly assigned to a validation sample and a cross-validation sample. The validation sample was used to develop predictive equations that were cross-validated using the other sample. Subjects Two hundred twenty-three healthy Chinese adults (102 men and 121 women) participated in the study. Their ages ranged from 20 to 78 years old (mean=43.8±14.3 years). Measures BMR was measured by indirect calorimetry. Body composition was assessed by skinfold fat thicknesses, bioelectrical impedance analysis, and urinary creatinine excretion. Statistical analyses performed Student's t test, Pearson correlation coefficients, linear regression analyses, and the best subset were used for statistical analyses. Results The better-fitting equation for predicting BMR in Chinese adults is BMR=13.88 × weight (kg) + 4.16 × height (cm) − 3.43 × age (years) − 112.40 × sex (men=0; women=1) + 54.34. Men had higher BMR values than women because men had greater fat-free mass, body cell mass, and muscle mass. BMR correlated best with body composition, which correlated highly with anthropometric measurements. Therefore, accurate determination of body weight and body height are beneficial in predicting a person's BMR. All of the currently available predictive equations overestimated BMR ( P =.0001) for healthy Chinese adults. The equations developed in this study predict BMR more accurately for Chinese adults. Applications The equations developed in this study are recommended for clinical use in healthy Chinese adults who are within normal limits for body weight. J Am Diet Assoc. 1995; 95:1403-1408.

Comorbidities of dry eye disease: a nationwide population-based study.

Abstract: . Purpose: To investigate the comorbidities of dry eye disease in a nationwide population-based data in Taiwan. Methods: This study features a study group and a comparison group. The study group comprised 12 007 patients who sought ambulatory care for treatment of dry eye in 2005 and 2006. In total, 36 021 randomly selected patients were in the comparison group. Conditional logistic regression analyses conditioned on gender, age, monthly income and level of urbanization of the community in which the patient resided were conducted to calculate the odds ratio (OR) for each of 33 comorbidities among patients with and without dry eye disease. Results: The regression analyses revealed that compared to patients without dry eye disease, patients with dry eye disease were more likely to have comorbidities of ischaemic heart disease (OR = 1.36), hyperlipidaemia (OR = 1.68), cardiac arrhythmias (OR = 1.55), peripheral vascular disorders (OR = 1.57), stroke (OR = 1.31), migraines (OR = 1.76), myasthenia gravis (OR = 2.85), RA (OR = 2.86), systemic lupus erythematosus (OR = 3.98), asthma (OR = 1.25), pulmonary circulation disorders (OR = 1.37), diabetes with complications (OR = 1.31), hypothyroidism (OR = 1.94), liver diseases (OR = 1.71), peptic ulcers (OR = 1.76), hepatitis B (OR = 1.64), deficiency anaemias (OR = 1.31), depression (OR = 2.11), psychoses (OR = 1.87) and solid tumours without metastasis (OR = 1.41). Conclusions: This study demonstrates significantly higher prevalence of medical comorbidities in patients with dry eye disease in Taiwan.

Molecular Aggregation of Annular Dinuclear Gold(I) Compounds Containing Bridging Diphosphine and Dithiolate Ligands.

Abstract: A series of annular dinuclear Au(I) complexes containing diphosphine (R2P(CH2)nPR2; R = Me, n = 1, dmpm; R = Me, n = 2, dmpe; R = Ph, n = 1, dppm; R = Ph, n = 2, dppe) and dithiolate (dtc = S2CNEt2-, i-mnt = S2C2(CN)22-) ligands were synthesized: [Au2(P-P)(S-S)]X (S-S = dtc: P-P = dmpm, X = Cl, 1; P-P = dppm, X = PF6, 2; P-P = dppe, X = PF6, 3; P-P = PPh3, X = PF6, 4) and [Au2(P-P)(S-S)] (S-S = i-mnt: P-P = dmpm, 5; P-P = dppm, 6; P-P = dmpe, 7; P-P = dppe, 8). Crystal structures of two complexes are reported. Pertinent crystallographic data: [Au2(dmpm)(i-mnt)] (5), space group Fdd2, with a = 19.574(3) A, b = 48.220(11) A, and c = 15.273(2) A, R = 0.0542; [Au2(dppe)(i-mnt)] (8), space group P21/n, with a = 11.793(2) A, b = 19.607(2) A, and c = 15.349(2) A, R = 0.0448. Each molecule has two gold atoms bridged by a dithiolate ligand on one side and a diphosphine ligand on the other side, thus forming an eight- or nine-membered ring digold complex. The tendency of the digold(I) compounds to aggregate thr...