Institution
Fundación Instituto Leloir
Facility•Buenos Aires, Argentina•
About: Fundación Instituto Leloir is a facility organization based out in Buenos Aires, Argentina. It is known for research contribution in the topics: Dentate gyrus & Neurogenesis. The organization has 702 authors who have published 1052 publications receiving 39299 citations.
Topics: Dentate gyrus, Neurogenesis, RNA, Arabidopsis, Population
Papers published on a yearly basis
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4 citations
TL;DR: A high-resolution crystal structure of the M2–1 RNA-binding domain of Human syncytial respiratory virus was determined and a combination of crystallography and SAXS indicated a role in its C-terminal extension.
Abstract: Human syncytial respiratory virus is a nonsegmented negative-strand RNA virus with serious implications for respiratory disease in infants, and has recently been reclassified into a new family, Pneumoviridae. One of the main reasons for this classification is the unique presence of a transcriptional antiterminator, called M2–1. The puzzling mechanism of action of M2–1, which is a rarity among antiterminators in viruses and is part of the RNA polymerase complex, relies on dissecting the structure and function of this multidomain tetramer. The RNA-binding activity is located in a monomeric globular `core' domain, a high-resolution crystal structure of which is now presented. The structure reveals a compact domain which is superimposable on the full-length M2–1 tetramer, with additional electron density for the C-terminal tail that was not observed in the previous models. Moreover, its folding stability was determined through chemical denaturation, which shows that the secondary and tertiary structure unfold concomitantly, which is indicative of a two-state equilibrium. These results constitute a further step in the understanding of this unique RNA-binding domain, for which there is no sequence or structural counterpart outside this virus family, in addition to its implications in transcription regulation and its likeliness as an antiviral target.
4 citations
TL;DR: Trehalose-freezing medium allowed us to cryopreserve melanoma cells, either alive or after gamma irradiation, at -84°C avoiding the use of Me(2)SO and liqN(2), which could be suitable for future freeze-drying of CSF470 vaccine.
4 citations
TL;DR: Interestingly, over-expression of AtCBF1 in potato plants not only conferred tolerance to low temperatures, as previously reported, but also to high-light conditions at 22 °C, suggesting that it confers multiple stress tolerance by enhancing the ability of plants to cope with an excess of radiant energy.
Abstract: Fil: Storani, Leonardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Parque Centenario. Instituto de Investigaciones Fisiologicas y Ecologicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de Agronomia. Instituto de Investigaciones Fisiologicas y Ecologicas Vinculadas a la Agricultura; Argentina
4 citations
TL;DR: In this article, the role of cholinergic modulation in the processing of afferent inputs in the dentate gyrus of the hippocampus has been evaluated by performing electrophysiology and optogenetics.
4 citations
Authors
Showing all 707 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jorge J. Casal | 61 | 182 | 10814 |
| Silvia N.J. Moreno | 61 | 225 | 10585 |
| Won Sang Park | 58 | 227 | 10501 |
| Su Young Kim | 51 | 198 | 8829 |
| Marcelo J. Yanovsky | 44 | 93 | 7949 |
| Mario D. Galigniana | 40 | 99 | 5257 |
| Eduardo M. Castaño | 40 | 89 | 7125 |
| Andrea V. Gamarnik | 38 | 82 | 5896 |
| Osvaldo L. Podhajcer | 35 | 122 | 4996 |
| Alejandro F. Schinder | 34 | 64 | 10256 |
| Juliana Idoyaga | 32 | 63 | 5326 |
| Fernando Alberto Goldbaum | 32 | 103 | 3385 |
| Fernando Juan Pitossi | 31 | 65 | 4489 |
| Kevin Gaston | 29 | 78 | 2725 |
| Jong Woo Lee | 29 | 77 | 3453 |