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Institution

Fundación Instituto Leloir

FacilityBuenos Aires, Argentina
About: Fundación Instituto Leloir is a facility organization based out in Buenos Aires, Argentina. It is known for research contribution in the topics: Dentate gyrus & Neurogenesis. The organization has 702 authors who have published 1052 publications receiving 39299 citations.


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Book ChapterDOI
01 Jan 2015
TL;DR: The blueprint of the core Clockwork in plants is reviewed and how the core clockwork orchestrates time-of-day-specific gene expression programmes is reviewed.
Abstract: Plants are exposed to periodic changes of light and darkness in their habitats through the Earth’s rotation around its axis. Accordingly, plants have evolved an endogenous system to schedule their day in synchrony with their surroundings. Here, we review the blueprint of the core clockwork in plants and how the core clockwork orchestrates time-of-day-specific gene expression programmes.

3 citations

01 Jan 2015
TL;DR: A partir de una encuesta entre graduados de un tradicional curso-taller de introduccion al periodismo cientifico, se constata que el 89,5 por ciento de ex alumnos que no adoptaron la especialidad como fuente de trabajo prioritaria declaro haber podido aplicar los conocimientos adquiridos tanto en su trabalo como en otros planos de su vida as discussed by the authors.
Abstract: Con el objeto de difundir los avances, dilemas, contextos y aplicaciones de la ciencia y la tecnologia, el periodismo cientifico se legitimo como una rama del periodismo desde mediados del siglo pasado. Un numero creciente de universidades e instituciones capacitan a profesionales de diferentes disciplinas en la comunicacion de la ciencia. ?Pero que aptitudes y habilidades rescatan y aplican aquellos graduados que, finalmente, exploran caminos diferentes y no siguen una carrera en ese campo? A partir de una encuesta entre graduados de un tradicional curso-taller de introduccion al periodismo cientifico, se constata que el 89,5 por ciento de ex alumnos que no adoptaron la especialidad como fuente de trabajo prioritaria declaro haber podido aplicar los conocimientos adquiridos tanto en su trabajo como en otros planos de su vida. Se destaca, segun ellos, la utilizacion de herramientas del periodismo cientifico en el aula y el desarrollo de la capacidad de lectura critica de las noticias.

3 citations

Journal ArticleDOI
TL;DR: In this article, a mutant with a kanamycin resistance insertion in the rsh gene of Bradyrhizobium diazoefficiens, the N2-fixing symbiont of soybean, was found to be defective for type 3 secretion system induction, plant defense suppression at early root infection, and nodulation competition.
Abstract: When subjected to nutritional stress, bacteria modify their amino acid metabolism and cell division activities by means of the stringent response, which is controlled by the Rsh protein in alphaproteobacteria. An important group of alphaproteobacteria are the rhizobia, which fix atmospheric N2 in symbiosis with legume plants. Although nutritional stress is common for rhizobia while infecting legume roots, the stringent response has scarcely been studied in this group of soil bacteria. In this report, we obtained a mutant with a kanamycin resistance insertion in the rsh gene of Bradyrhizobium diazoefficiens, the N2-fixing symbiont of soybean. This mutant was defective for type 3 secretion system induction, plant defense suppression at early root infection, and nodulation competition. Furthermore, the mutant produced smaller nodules, although with normal morphology, which led to lower plant biomass production. Soybean (Glycine max) genes GmRIC1 and GmRIC2, involved in autoregulation of nodulation, were upregulated in plants inoculated with the mutant under the N-free condition. In addition, when plants were inoculated in the presence of 10 mM NH4NO3, the mutant produced nodules containing bacteroids, and GmRIC1 and GmRIC2 were downregulated. The rsh mutant released more auxin to the culture supernatant than the wild type, which might in part explain its symbiotic behavior in the presence of combined N. These results indicate that the B. diazoefficiens stringent response integrates into the plant defense suppression and regulation of nodulation circuits in soybean, perhaps mediated by the type 3 secretion system. IMPORTANCE The symbiotic N2 fixation carried out between prokaryotic rhizobia and legume plants performs a substantial contribution to the N cycle in the biosphere. This symbiotic association is initiated when rhizobia infect and penetrate the root hairs, which is followed by the growth and development of root nodules, within which the infective rhizobia are established and protected. Thus, the nodule environment allows the expression and function of the enzyme complex that catalyzes N2 fixation. However, during early infection, the rhizobia find a harsh environment while penetrating the root hairs. To cope with this nuisance, the rhizobia mount a stress response known as the stringent response. In turn, the plant regulates nodulation in response to the presence of alternative sources of combined N in the surrounding medium. Control of these processes is crucial for a successful symbiosis, and here we show how the rhizobial stringent response may modulate plant defense suppression and the networks of regulation of nodulation.

3 citations

Posted ContentDOI
25 Aug 2021-medRxiv
TL;DR: In this article, longitudinal antibody responses and viral neutralizing capacity to the B.1 lineage virus (Wuhan related), to variants of concern (VOCs: Alpha, Beta, Gamma, and Delta) and a local variant of interest (VOI: Lambda) in volunteers receiving the Sputnik V vaccine in Argentina were examined.
Abstract: Recent studies have shown a temporal increase in the neutralizing antibody potency and breadth to SARS-CoV-2 variants in coronavirus disease 2019 (COVID-19) convalescent individuals. Here, we examined longitudinal antibody responses and viral neutralizing capacity to the B.1 lineage virus (Wuhan related), to variants of concern (VOCs: Alpha, Beta, Gamma, and Delta) and a local variant of interest (VOI: Lambda) in volunteers receiving the Sputnik V vaccine in Argentina. A collection of 472 serum samples obtained between January and September 2021 was used. The analysis indicates that while anti-spike IgG levels significantly wane over time, the neutralizing capacity to the first-wave linages of SARS-CoV-2 and VOC are maintained within four months of vaccination. In addition, an improved antibody cross-neutralizing ability to circulating variants of concern (Beta, Gamma and Delta) was observed over time of vaccination. The viral variants that displayed higher escape to neutralizing antibodies with respect to the original virus (Beta and Gamma variants) were the ones showing the largest increase in susceptibility to neutralization over time after vaccination. Our observations indicate that serum neutralizing antibodies are maintained for at least four month and show a reduction of VOC escape over time of vaccination.

3 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202210
2021107
202099
201986
201865
201781