Gadjah Mada University

About: Gadjah Mada University is a education organization based out in Yogyakarta, Indonesia. It is known for research contribution in the topics: Population & Adsorption. The organization has 17307 authors who have published 21389 publications receiving 116561 citations. The organization is also known as: University of Gajah Mada & Universitas Gadjah Mada.

Vehicle Routing Problem with Drones Considering Time Windows

Abstract: The cooperation of trucks and unmanned aerial vehicles (UAV) has become a new delivery method in the area of logistics and transportation. In this form of cooperation, the trucks are not only able to provide services to the customers, but also serve as a ‘launch pad’ for the drones, in which the drones can be launched to service a customer and then recovered at the rendezvous node. This study intends to explore this cooperation by developing a model for the vehicle routing problem with drones that considers the presence of customer time windows (VRPTWD). A mixed-integer programming (MIP) model is presented to minimize the total travelling time of all trucks. Then, a simple yet effective variable neighborhood search (VNS) procedure with a novel solution representation is proposed as a solver. The numerical results indicate the ability of the proposed VNS to solve the VRPTWD, as well as the improvement of delivery performance using drones.

Green Chemistry Influences in Organic Synthesis : a Review

Abstract: Environmental pollution and global warming cause serious problems in human life. Since the demand for our human daily appliances had been increased by years, the organic chemical-based industries response that demand increment by increasing their production process. Because of that, the environmental pollution becomes worse and worse. Green chemistry thus was introduced to influence the chemical industries to strive for better environmental sustainability. Over 20 years, green chemistry principles have to influence the organic chemistry field especially as many researchers have put their attention on that field of research. So far, synthesis process involving organic compounds has been considered on waste prevention, safer solvents, design for high energy efficiency, and usage of renewable feedstocks. This review comprehensively discusses in brief about the implementation of green chemistry principle and their applications in the synthesis process of organic compounds.

Plant-derived exosome-like nanoparticles: A concise review on its extraction methods, content, bioactivities, and potential as functional food ingredient.

Abstract: Plant-derived exosome-like nanoparticles (PDENs) are small vesicles released by multivesicular bodies mainly to communicate between cells and regulate immunity against pathogen attack. Current studies have reported that PDENs could modulate gene expression in a cross-kingdom fashion. Therefore, PDENs could be a potential future functional food ingredient as their cross-kingdom communication abilities were reported to exert multiple health benefits. Macrophage and other cells have been reported to absorb PDENs in a manner regulated by the membrane lipid and protein profile and the intactness of the PDENs lipid bilayer. PDENs could be extracted from plant materials by various techniques such as ultracentrifugation, immunoaffinity, size-based isolation, and precipitation, though each method has its pros and cons. PDENs mainly contain lipid, protein, and genetic materials, mainly micro RNAs, which could exert multiple health benefits and functionalities when consumed in sufficient amounts. However, most studies on the health functionalities of PDENs were conducted through in-vitro and in-vivo studies, and its potency to be used as a functional ingredient remains a question as PDENs are sensitive to storage and processing condition and requires costly extraction method. This concise review features various exosome extraction methods, contents of PDENs and their roles, the health functionalities of PDENs, and its potency as a functional food ingredient.