Gadjah Mada University

About: Gadjah Mada University is a education organization based out in Yogyakarta, Indonesia. It is known for research contribution in the topics: Population & Adsorption. The organization has 17307 authors who have published 21389 publications receiving 116561 citations. The organization is also known as: University of Gajah Mada & Universitas Gadjah Mada.

Geriatric prescribing in the medical wards of a teaching hospital in Nepal.

Abstract: A retrospective study on prescribing patterns for 100 randomly selected geriatric patients admitted over a period of 1 year to the medical wards of the Tribhuvan University Teaching Hospital (TUTH) in Nepal showed that polypharmacy was prevalent. During a hospital stay, 73% patients received more than five, 54% received more than eight, and 24% received more than nine drugs concurrently. Although the average drug exposure per patient during a hospital stay was found to be 11.2, this figure would actually go up to 14.5 if all the active ingredients of the fixed-dose combination products prescribed (15.4% of all drugs) were taken into account. Intravenous fluids were the most commonly prescribed drugs and were given to 91% of the patients. Antibiotics (excluding metronidazole and antituberculous drugs) were given to over three-quarters (77%) of the patients. Ciprofloxacin was the most commonly prescribed antibiotic. Of the 42 patients treated with this drug, 31 (73.8%) received it intravenously, either for a part of or throughout the course. This antibiotic was prescribed concurrently with theophylline in 14 patients without the facility for monitoring plasma-theophylline levels. It was also administered at the same time as antacid in nine patients. Nearly half (46.4%) of the drugs were prescribed by brand or proprietary names. The prescribing error of leaving the prescription card undated or unsigned when prescribing or stopping drugs was found to be high. The results of this survey indicate that there is considerable scope for improving geriatric prescribing practices in the medical wards of TUTH. © 1997 John Wiley & Sons, Ltd.

A potential bacterial biocontrol agent, strain S2V2 against pathogenic marine Vibrio in aquaculture

Abstract: We isolated a marine bacterium strain S2V2 which inhibited the growth of pathogenic marine Vibrio spp. The aims of this research were to identify a new antibiotic-producing marine bacterium strain S2V2, and evaluate its spectrum activity and pathogenic property. Analysis of 16S rDNA sequence placed strain S2V2 in the genus Pseudoalteromonas, but the sequence similarity was low (95.46%) implying the strain might be a new species in this genus. Strain S2V2 inhibited the growth of 67.9% of 28 Vibrio strains tested. This strain inhibited V. alginolyticus, V. anguillarum, V. fluvialis, V. harveyi, V. metschnikovii, V. splendidus, V. ordalii, V. parahaemolyticus, and V. vulnificus, but inactive against V. campbellii, Aeromonas hydrophyla and Staphylococcus aureus. Strain S2V2 produced extracellular non proteinaceous antibacterial substances. The highest antibacterial activity was found when strain S2V2 was cultured for 96 h in ZoBell broth medium. An artificial infection to post larvae of Lithopenaeus vanname indicated that strain S2V2 was a non pathogenic bacterium. Non pathogenic property and specific antibacterial activity against a broad range of fish pathogenic marine Vibrio of strain S2V2 suggest that this strain is a prospective source of unique antibiotic and a potential biocontrol agent in marine aquaculture.