Institution
Gadjah Mada University
Education•Yogyakarta, Indonesia•
About: Gadjah Mada University is a education organization based out in Yogyakarta, Indonesia. It is known for research contribution in the topics: Population & Adsorption. The organization has 17307 authors who have published 21389 publications receiving 116561 citations. The organization is also known as: University of Gajah Mada & Universitas Gadjah Mada.
Topics: Population, Adsorption, Medicine, Context (language use), Government
Papers published on a yearly basis
Papers
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TL;DR: Training in development and use of a personal formulary was particularly effective in universities with a classic curriculum and with traditional pharmacology teaching, and in universities that had a mainly classic curriculum.
Abstract: Objective
This study was performed to determine whether students who are trained in developing a personal formulary become more competent in rational prescribing than students who have only learned to use existing formularies.
48 citations
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TL;DR: The iron(II) complexes studied have higher affinity towards the more facile A-T sequence than the G-C sequence, which may be attributed to the steric effect induced by the ancillary part of the ligands in the course of DNA binding.
48 citations
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Charles Darwin University1, Eijkman Institute for Molecular Biology2, French Institute of Health and Medical Research3, Pasteur Institute4, University of Notre Dame5, Catalan Institution for Research and Advanced Studies6, University of Barcelona7, Harvard University8, University of Glasgow9, University of Oxford10, Mahidol University11, University of Otago12, Gadjah Mada University13, University of Indonesia14
TL;DR: A very large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human individuals infected with Plasmodium vivax as discussed by the authors.
Abstract: Background A very large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human individuals infected with Plasmodium vivax. The mechanisms underlying this intense tropism are not clear. We hypothesised that immature reticulocytes, in which P. vivax develops, may display high densities in the spleen, thereby providing a niche for parasite survival. Methods and findings We examined spleen tissue in 22 mostly untreated individuals naturally exposed to P. vivax and Plasmodium falciparum undergoing splenectomy for any clinical indication in malaria-endemic Papua, Indonesia (2015 to 2017). Infection, parasite and immature reticulocyte density, and splenic distribution were analysed by optical microscopy, flow cytometry, and molecular assays. Nine non-endemic control spleens from individuals undergoing spleno-pancreatectomy in France (2017 to 2020) were also examined for reticulocyte densities. There were no exclusion criteria or sample size considerations in both patient cohorts for this demanding approach. In Indonesia, 95.5% (21/22) of splenectomy patients had asymptomatic splenic Plasmodium infection (7 P. vivax, 13 P. falciparum, and 1 mixed infection). Significant splenic accumulation of immature CD71 intermediate- and high-expressing reticulocytes was seen, with concentrations 11 times greater than in peripheral blood. Accordingly, in France, reticulocyte concentrations in the splenic effluent were higher than in peripheral blood. Greater rigidity of reticulocytes in splenic than in peripheral blood, and their higher densities in splenic cords both suggest a mechanical retention process. Asexual-stage P. vivax-infected erythrocytes of all developmental stages accumulated in the spleen, with non-phagocytosed parasite densities 3,590 times (IQR: 2,600 to 4,130) higher than in circulating blood, and median total splenic parasite loads 81 (IQR: 14 to 205) times greater, accounting for 98.7% (IQR: 95.1% to 98.9%) of the estimated total-body P. vivax biomass. More reticulocytes were in contact with sinus lumen endothelial cells in P. vivax- than in P. falciparum-infected spleens. Histological analyses revealed 96% of P. vivax rings/trophozoites and 46% of schizonts colocalised with 92% of immature reticulocytes in the cords and sinus lumens of the red pulp. Larger splenic cohort studies and similar investigations in untreated symptomatic malaria are warranted. Conclusions Immature CD71+ reticulocytes and splenic P. vivax-infected erythrocytes of all asexual stages accumulate in the same splenic compartments, suggesting the existence of a cryptic endosplenic lifecycle in chronic P. vivax infection. Findings provide insight into P. vivax-specific adaptions that have evolved to maximise survival and replication in the spleen.
48 citations
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TL;DR: It is suggested that longer eyes have decreased retinal function and O₂ consumption, and thus are relatively less hypoxic in the presence of diabetes, which may partly explain the reduced risk of DR in these eyes.
Abstract: Purpose To determine the relationship between axial length (AL), retinal function, and relative oxygen (O₂) consumption to better understand the protective effect of axial elongation on diabetic retinopathy development. Methods Measurements of AL, multifocal electroretinogram (mfERG), and relative O₂ consumption (difference between arteriolar and venular O₂ saturation levels or A-V difference) were performed on 50 healthy individuals. The relationships between AL, mfERG amplitude, and A-V difference were analyzed using linear regression models. Path analysis was performed to determine the direct and indirect effects (via mfERG amplitude) of AL on A-V difference. Results mfERG P1 amplitude was positively associated with A-V difference (β = 0.33; 95% confidence interval [CI]: 0.23-0.42). Increased AL was significantly associated with a decrease in A-V difference (β = -1.08; 95% CI: -1.52 to -0.65) as well as a decrease in retinal function (β = -3.14, 95% CI: -4.07 to -2.20). Path analysis models including AL (study factor), retinal function (intermediate variable), and A-V difference (outcome variable) showed that AL had little direct association with A-V difference (β(p) = -0.002), while the indirect effect of AL on A-V difference via changes in retinal function were substantial (β(p) = -0.51). Conclusions In eyes with longer AL, the reduction in A-V difference is explained by the parallel reduction in retinal function. These findings suggest that longer eyes have decreased retinal function and O₂ consumption, and thus are relatively less hypoxic in the presence of diabetes, which may partly explain the reduced risk of DR in these eyes.
48 citations
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TL;DR: The results show that the proposed methods, namely the SSA-LRF-NN algorithm can reduce the RMSE for the testing data from that obtained by SSA -LRF up to 83%.
48 citations
Authors
Showing all 17450 results
Name | H-index | Papers | Citations |
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Bunsho Ohtani | 71 | 371 | 19052 |
Lawrence H. Moulton | 71 | 266 | 20663 |
John M. Nicholls | 66 | 231 | 19014 |
Paul Meredith | 59 | 308 | 15489 |
Bernd M. Rode | 52 | 441 | 11367 |
Jan-Willem C. Alffenaar | 43 | 294 | 6378 |
Bernd Lehmann | 41 | 218 | 6027 |
Nawi Ng | 39 | 152 | 4470 |
Jean-Philippe Gastellu-Etchegorry | 38 | 192 | 4860 |
Mohd Hamdi | 38 | 190 | 5846 |
Keiko Sasaki | 36 | 319 | 5341 |
Jos G. W. Kosterink | 36 | 167 | 5132 |
A. C. Hayward | 34 | 106 | 6538 |
Eileen S. Scott | 33 | 177 | 3187 |
Michael R. Dove | 33 | 142 | 4334 |