Showing papers by "Gdańsk Medical University published in 1990"
TL;DR: The mosaic occurrence of trisomy 7 in four consecutive short-term cultures initiated from normal kidney tissue is reported, and the only culture established from a male showed mosaic loss of the Y chromosome.
Abstract: Numerical chromosome aberrations are common in several types of malignant tumors. Recently, trisomy 7 and loss of the Y chromosome were described in cultures from nonneoplastic tissue, making the significance of these aberrations as cancer-associated changes doubtful. We herein report the mosaic occurrence of trisomy 7 in four consecutive short-term cultures initiated from normal kidney tissue. Smaller clones with trisomy 10 were present in three cases, and the only culture established from a male also showed mosaic loss of the Y chromosome.
135 citations