Showing papers by "Gdańsk Medical University published in 1993"
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TL;DR: In this paper, a review of the theoretical background of QSRR and its application in the search for new reliable and precise descriptors of the structures of solutes of relevance to their properties, including properties other than chromatographic, e.g., bioactivity.
185 citations
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TL;DR: The fact that the deletions were found as solitary changes indicates that loss of genetic information from 3p loci is an early, possibly primary, event in tumorigenesis.
Abstract: Interstitial deletions of the short arm of chromosome 3 were found in short-term cultures of five breast carcinomas (of 41 breast cancers with clonal aberrations analyzed by us during the same period). They were the only clonal structural change in three tumors; in the remaining two, the clone with 3p– coexisted with seemingly unrelated clones that had other structural and numerical aberrations. The deletions were identical, del(3)(p12p14), in four cases. The fifth tumor seemed to have a smaller deletion, interpreted as del(3)(p13p14). Our findings constitute karyotypic evidence that 3p deletions are relatively common in breast carcinomas and concur with the molecular genetic detection of loss of heterozygosity in this chromosome arm. The fact that the deletions were found as solitary changes indicates that loss of genetic information from 3p loci is an early, possibly primary, event in tumorigenesis. © 1993 Wiley-Liss, Inc.
67 citations
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TL;DR: For a set of 22 drugs known to modify physiological effects of endogenous histamine, high-performance liquid chromatographic (HPLC) retention data were determined employing two reversed phase columns, seven compositions of methanol, buffer eluent and three pH values (acidic, neutral and alkaline) of the buffer.
33 citations
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TL;DR: An approach was proposed to reduce the number of pharmacological tests in selecting the most promising agents based on the results obtained and an in vivo antithrombotic assay on mice proved diversified bioactivity within the group of agents.
Abstract: 1. 1. A series of newly synthesized pyrazine CH- and NH-acids was subjected to analytical and pharmacological studies. 2. 2. The compounds were chromatographed in HPLC systems employing three reversed-phase columns and methanol-buffer solvents of various composition at acidic, neutral and alkaline pH. 3. 3. Chemometrical analysis by the principal component method allowed for ordering of the compounds on a plane determined by the first two principal component axes. 4. 4. Pharmacological tests were done for representatives of the series of compounds. 5. 5. An in vivo antithrombotic assay on mice proved diversified bioactivity within the group of agents. 6. 6. Attempts were undertaken to relate chromatographic behaviour to antithrombotic activity. 7. 7. Based on the results obtained, an approach was proposed to reduce the number of pharmacological tests in selecting the most promising agents.
17 citations
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TL;DR: Post-mortem MRI studies followed by histopathological examination were used to study the size and the shape of the lateral part of the transverse fissure of the brain in seven individuals with Alzheimer disease (AD) and five controls, indicating the relationship between changes in the hippocampal and parahippocampal structures and the size of theateral part ofThe transverse Fissure.
Abstract: Post-mortem MRI (magnetic resonance images) studies followed by histopathological examination were used to study the size and the shape of the lateral part of the transverse fissure of the brain in seven individuals with Alzheimer disease (AD) and five controls. In control brains, the lateral part of the transverse fissure is a narrow cleft protruding laterally as choroid and hippocampal recesses. In AD-affected brains, the lateral part of the transverse fissure becomes a large subarachnoid space as a result of different degrees of atrophy of various hippocampal and parahippocampal structures. Our findings directly indicate the relationship between changes in the hippocampal and parahippocampal structures and the size of the lateral part of the transverse fissure. Sector CA1, the subiculum, the entorhinal cortex, and the parahippocampal isocortex are the most affected, whereas the dentate gyrus is much less affected. Adjacent thalamic structures, which are less vulnerable to the AD pathology, do not appear to contribute to transverse fissure changes. The size and the shape of the lateral part of the transverse fissure of the brain in AD reflect the atrophy of the hippocampus and parahippocampal structures.
15 citations
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TL;DR: Negative chronotropic properties appeared to be independent of the alpha-adrenoceptors and may result from the membrane stabilizing action, involving probably the sodium channel blockade.
Abstract: Effects of cumulative concentrations of 16 known imidazoline and 2 imidazole drugs on amplitude and rate of spontaneously beating isolated rat heart atria were measured and related to the respective effects induced by norepinephrine In addition, the effects of fixed concentrations of the agents on the responses evoked by cumulative concentrations of norepinephrine were determined In general, imidazolines classified as alpha 1-adrenoceptor agonist showed positive inotropic activity providing evidence for involvement of the alpha 1-adrenoceptor in mediating cardiac contractility Negative chronotropic effect was common for the imidazolines studied, including alpha 1-adrenoceptor agonists, alpha 2-adrenoceptor agonists, alpha 1/alpha 2-adrenoceptor antagonists and antazoline--an antihistaminergic imidazoline devoid of adrenoceptor affinity On the other hand, the imidazole derivative, medetomidine, showed a weak positive chronotropic activity Negative chronotropic properties appeared to be independent of the alpha-adrenoceptors and may result from the membrane stabilizing action, involving probably the sodium channel blockade
5 citations