Institution
Gdańsk Medical University
Education•Gdańsk, Poland•
About: Gdańsk Medical University is a education organization based out in Gdańsk, Poland. It is known for research contribution in the topics: Population & Cancer. The organization has 4893 authors who have published 11216 publications receiving 260523 citations.
Topics: Population, Cancer, Transplantation, Blood pressure, Breast cancer
Papers published on a yearly basis
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TL;DR: The contemporary knowledge on the toxicity of breast-cancer radiotherapy is reviewed and possible preventive measures are discussed.
87 citations
TL;DR: The primary objective is to evaluate the best strategy for sequencing of treatment with gefitinib and osimertinib in advanced NSCLC patients with common EGFR mutations, and to understand the value of liquid biopsy for the decision-making process.
86 citations
TL;DR: It is concluded that presence of homozygous KIT exon 11 mutations is associated with malignant course of disease and should be considered an adverse prognostic marker in GISTs.
86 citations
TL;DR: The discovery of oncogenic BRAF mutations and the presence of proinflammatory cytokines and chemokines confirmed the unusual characteristics of Langerhans cell histiocytosis.
Abstract: Langerhans cell histiocytosis is a rare clonal disease characterized by the proliferation of CD1a-positive immature dendritic cells. The purpose of this article was to present an updated review of recent advances in the pathogenesis, clinical features, imaging and treatment of this disease. The discovery of oncogenic BRAF mutations and the presence of proinflammatory cytokines and chemokines confirmed the unusual characteristics of this disease. Currently, children with organ involvement who do not have a good response to chemotherapy and have neurodegeneration or diabetes insipidus are the most problematic patients. Further research is needed to improve the results of treatment.
86 citations
TL;DR: It is reported that experimental breast cancer brain metastases of low- and high permeability to a dextran dye exhibit distinct microenvironmental gene expression patterns, and neuroinflammatory astrocytic S1P3 modulates BTB permeability.
Abstract: Brain metastases are devastating complications of cancer. The blood-brain barrier (BBB), which protects the normal brain, morphs into an inadequately characterized blood-tumor barrier (BTB) when brain metastases form, and is surrounded by a neuroinflammatory response. These structures contribute to poor therapeutic efficacy by limiting drug uptake. Here, we report that experimental breast cancer brain metastases of low- and high permeability to a dextran dye exhibit distinct microenvironmental gene expression patterns. Astrocytic sphingosine-1 phosphate receptor 3 (S1P3) is upregulated in the neuroinflammatory response of the highly permeable lesions, and is expressed in patients' brain metastases. S1P3 inhibition functionally tightens the BTB in vitro and in vivo. S1P3 mediates its effects on BTB permeability through astrocytic secretion of IL-6 and CCL2, which relaxes endothelial cell adhesion. Tumor cell overexpression of S1P3 mimics this pathway, enhancing IL-6 and CCL-2 production and elevating BTB permeability. In conclusion, neuroinflammatory astrocytic S1P3 modulates BTB permeability.
86 citations
Authors
Showing all 4927 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Magdi H. Yacoub | 109 | 1267 | 52431 |
| Virend K. Somers | 106 | 615 | 54203 |
| Felix Mitelman | 95 | 578 | 35416 |
| Andrzej Slominski | 91 | 469 | 27900 |
| Nils Mandahl | 86 | 427 | 25006 |
| Fredrik Mertens | 84 | 406 | 28705 |
| Enriqueta Felip | 83 | 622 | 53364 |
| Pieter E. Postmus | 81 | 384 | 24039 |
| Wilhelm Kriz | 73 | 222 | 19335 |
| Godefridus J. Peters | 73 | 523 | 28315 |
| Jacek Jassem | 73 | 602 | 35976 |
| Piotr Rutkowski | 72 | 563 | 42218 |
| Thomas Frodl | 70 | 258 | 16469 |
| Eric J. Velazquez | 70 | 396 | 27539 |
| Argye E. Hillis | 68 | 398 | 22230 |