Gdańsk Medical University

About: Gdańsk Medical University is a education organization based out in Gdańsk, Poland. It is known for research contribution in the topics: Population & Cancer. The organization has 4893 authors who have published 11216 publications receiving 260523 citations.

Histological evaluation of mineral trioxide aggregate and calcium hydroxide in direct pulp capping of human immature permanent teeth.

Abstract: PURPOSE To evaluate histological findings in human immature permanent premolars scheduled for extraction for orthodontic reasons, in which mechanical pulp exposures were capped with white ProRoot Mineral Trioxide Aggregate (WMTA) or calcium hydroxide (CH). METHODS Forty-eight human immature premolars in 23 patients (age 10-18 years) were randomly treated with WMTA or CH. After rubber dam isolation Cl I cavities were prepared and the pulps exposed. After hemostasis the pulps were capped with either material. The preparations were restored using an acid etch, bonding agent, flowable composite and composite resin technique. The teeth were extracted after 47 to 609 days and processed for routine histological examination, stained with hematoxylin and eosin and Brown and Brenn for recognition of bacteria. Statistical analyses of inflammation, bridge formation and bacterial leakage were performed using a Chi-square test and ANOVA. RESULTS Forty-four of 48 teeth were suitable for microscopic evaluation, 30 with WMTA, 14 with CH. Of the WMTA group, 29 teeth were vital, 28 had formed a bridge, and one specimen had failed. Twelve of 14 teeth with CH were vital, while three teeth failed to form a bridge. No statistically significant differences between WMTA and CH were found, except for superficial and deep inflammatory cell response (P < or = 0.05). Pulp capping of intentionally exposed human immature premolars performed slightly better when using MTA.

Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds.

Abstract: The broad spectrum of the mechanism of action of immune-boosting natural compounds as well as the complex nature of the food matrices make researching the health benefits of various food products a complicated task. Moreover, many routes are involved in the action of most natural compounds that lead to the inhibition of chronic inflammation, which results in a decrease in the ability to remove a pathogen asymptomatically and is connected to various pathological events, such as cancer. A number of cancers have been associated with inflammatory processes. The current review strives to answer the question of whether plant-derived sulfur compounds could be beneficial in cancer prevention and therapy. This review focuses on the two main sources of natural sulfur compounds: alliaceous and cruciferous vegetables. Through the presentation of scientific data which deal with the study of the chosen compounds in cancer (cell lines, animal models, and human studies), the discussion of food processing's influence on immune-boosting food content is presented. Additionally, it is demonstrated that there is still a need to precisely demonstrate the bioavailability of sulfur-containing compounds from various types of functional food, since the inappropriate preparation of vegetables can significantly reduce the content of beneficial sulfur compounds. Additionally, there is an urgent need to carry out more epidemiological studies to reveal the benefits of several natural compounds in cancer prevention and therapy.