Institution
Gdańsk Medical University
Education•Gdańsk, Poland•
About: Gdańsk Medical University is a education organization based out in Gdańsk, Poland. It is known for research contribution in the topics: Population & Cancer. The organization has 4893 authors who have published 11216 publications receiving 260523 citations.
Topics: Population, Cancer, Medicine, Blood pressure, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: The effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role ofTLRs in anti-cancer immunity and tumor rejection are discussed.
Abstract: In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.
163 citations
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TL;DR: This review discusses the methods applicable to find only lowest energy conformations and to generate canonical ensembles and coarse-grained models that enable simulations to be enhanced by several orders of magnitude.
163 citations
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Mayo Clinic1, Durham University2, National and Kapodistrian University of Athens3, University of Belgrade4, Semmelweis University5, Jagiellonian University6, Medical University of Silesia7, University of Pécs8, Ben-Gurion University of the Negev9, University of Debrecen10, Military Medical Academy11, Sofia University12, Bar-Ilan University13, Hillel Yaffe Medical Center14, Medical University of Łódź15, Hospital General Universitario Gregorio Marañón16, Université catholique de Louvain17, Hospital Clínico San Carlos18, University of Verona19, Gdańsk Medical University20, Thomas Jefferson University21, San Francisco VA Medical Center22, Cedars-Sinai Medical Center23, University of Brescia24, Icahn School of Medicine at Mount Sinai25, Campbell University26, National University of Ireland, Galway27
TL;DR: The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort, with safety demonstrated across the cohort.
Abstract: Aims Cardiopoietic cells, produced through cardiogenic conditioning of patients’ mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort.
Methods and results This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischemic heart failure on guideline-directed therapy ( n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion. Those achieving > 24 million mesenchymal stem cells ( n = 315) were randomized to cardiopoietic cells delivered endomyocardially with a retention-enhanced catheter ( n = 157) or sham procedure ( n = 158). Procedures were performed as randomized in 271 patients ( n = 120 cardiopoietic cells, n = 151 sham). The primary efficacy endpoint was a Finkelstein–Schoenfeld hierarchical composite (all-cause mortality, worsening heart failure, Minnesota Living with Heart Failure Questionnaire score, 6-min walk distance, left ventricular end-systolic volume, and ejection fraction) at 39 weeks. The primary outcome was neutral (Mann–Whitney estimator 0.54, 95% confidence interval [CI] 0.47–0.61 [value > 0.5 favours cell treatment], P = 0.27). Exploratory analyses suggested a benefit of cell treatment on the primary composite in patients with baseline left ventricular end-diastolic volume 200–370 mL (60% of patients) (Mann–Whitney estimator 0.61, 95% CI 0.52–0.70, P = 0.015). No difference was observed in serious adverse events. One (0.9%) cardiopoietic cell patient and 9 (5.4%) sham patients experienced aborted or sudden cardiac death.
Conclusion The primary endpoint was neutral, with safety demonstrated across the cohort. Further evaluation of cardiopoietic cell therapy in patients with elevated end-diastolic volume is warranted.
163 citations
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TL;DR: Strong sorption of the hydrophobic organic contaminant phenanthrene to the activated carbon or biochar surfaces was maintained following magnetite impregnation, while phenol sorption was diminished, probably due to enhanced carbon oxidation.
163 citations
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TL;DR: In this paper, the structure of π complexes of isocyanuric acid and of several thio derivatives with anions has been computed by using high level ab initio calculations, using the method of molecular interaction potential with polarization (MIPp) and Bader's theory of atoms-in-molecules.
Abstract: Several structures of π complexes of isocyanuric acid and of several thio derivatives with anions have been computed by using high level ab initio calculations. The nature of the complexes has been studied by means of the method of molecular interaction potential with polarization (MIPp) and Bader's theory of atoms-in-molecules. These molecules form favorable complexes with anions and can be used as binding units for building receptors for the molecular recognition of anions. In several cases, the anion–π interaction has been demonstrated experimentally by means of X-ray crystallography.
162 citations
Authors
Showing all 4927 results
Name | H-index | Papers | Citations |
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Magdi H. Yacoub | 109 | 1267 | 52431 |
Virend K. Somers | 106 | 615 | 54203 |
Felix Mitelman | 95 | 578 | 35416 |
Andrzej Slominski | 91 | 469 | 27900 |
Nils Mandahl | 86 | 427 | 25006 |
Fredrik Mertens | 84 | 406 | 28705 |
Enriqueta Felip | 83 | 622 | 53364 |
Pieter E. Postmus | 81 | 384 | 24039 |
Wilhelm Kriz | 73 | 222 | 19335 |
Godefridus J. Peters | 73 | 523 | 28315 |
Jacek Jassem | 73 | 602 | 35976 |
Piotr Rutkowski | 72 | 563 | 42218 |
Thomas Frodl | 70 | 258 | 16469 |
Eric J. Velazquez | 70 | 396 | 27539 |
Argye E. Hillis | 68 | 398 | 22230 |