Institution
Gdańsk Medical University
Education•Gdańsk, Poland•
About: Gdańsk Medical University is a education organization based out in Gdańsk, Poland. It is known for research contribution in the topics: Population & Cancer. The organization has 4893 authors who have published 11216 publications receiving 260523 citations.
Topics: Population, Cancer, Medicine, Blood pressure, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: This study provides the first evidence that PWV is linked to MSNA in normal humans, independent of age, BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or blood pressure.
Abstract: Objective Carotid-femoral pulse wave velocity (PWV) has been shown to be a powerful predictor of cardiovascular morbidity and mortality. Sympathetic neural mechanisms may have a stiffening influence on arterial mechanical properties. The relationship between direct measures of sympathetic traffic and PWV in healthy humans has not been previously studied. We, therefore, tested the hypothesis that PWV is independently linked to muscle sympathetic nerve activity (MSNA) in normal individuals. Methods We measured MSNA (microneurography), PWV (Complior device), heart rate and blood pressure in 25 healthy male participants (mean age 43 +/- 10 years). Results PWV correlated significantly with age (r=0.63, P<0.001), SBP (r=0.43, P<0.05) and MSNA (r=0.43, P<0.05) but not with BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or DBP. Robust multiple linear regression analysis revealed that only age and MSNA were linked independently to PWV (r(2)=0.62, P<0.001), explaining 39 and 25% of its variance, respectively. After adjustment of PWV for age and SBP, we further divided individuals into 'excessive' PWV (i.e. higher than expected from age and SBP) and 'optimal' PWV (i.e. lower than expected). BMI and blood pressure were similar in both subgroups. Individuals with excessive PWV had significantly greater MSNA than individuals with optimal PWV (30 +/- 10 vs. 18 +/- 11 bursts/min, P=0.01). Conclusion This study provides the first evidence that PWV is linked to MSNA in normal humans. The relationship between MSNA and PWV is independent of age, BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or blood pressure. J Hypertens 28:979-984 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
154 citations
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Baker IDI Heart and Diabetes Institute1, University of Erlangen-Nuremberg2, University of Chicago3, Utrecht University4, University of Southern California5, Imperial College London6, University of Milano-Bicocca7, University of Oslo8, Monash University9, Columbia University10, Gdańsk Medical University11, University of Düsseldorf12, Virginia Commonwealth University13, Ohio State University14, National and Kapodistrian University of Athens15, SUNY Downstate Medical Center16, University College London17
TL;DR: Clinical trial data available thus far have been obtained primarily in patients with resistant hypertension, defined as standardized systolic clinic blood pressure ≥ 160 mm Hg despite appropriate pharmacologic treatment with at least 3 antihypertensive drugs, including a diuretic agent.
153 citations
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TL;DR: This position statement of the European Federation of Societies in Ultrasound and Medicine (EFSUMB) assesses the current status of CEUS applications in children and makes suggestions for further development of this technique.
Abstract: The use of contrast-enhanced ultrasound (CEUS) in adults is well established in many different areas, with a number of current applications deemed “off-label”, but the use supported by clinical experience and evidence. Paediatric CEUS is also an “off-label” application until recently with approval specifically for assessment of focal liver lesions. Nevertheless there is mounting evidence of the usefulness of CEUS in children in many areas, primarily as an imaging technique that reduces exposure to radiation, iodinated contrast medium and the “patient-friendly” circumstances of ultrasonography. This position statement of the European Federation of Societies in Ultrasound and Medicine (EFSUMB) assesses the current status of CEUS applications in children and makes suggestions for further development of this technique.
153 citations
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TL;DR: In this article, the development of air quality policies in the United States of America and European Union was analyzed and it was shown how these legislations were implemented and also the air quality policy in these states were compared.
153 citations
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TL;DR: A collaborative study on patient characteristics and treatment outcomes in children who started RRT as neonates during their first month of life between 2000 and 2011 found relatively good medium-term patient survival may be achieved with RRT started during the neonatal period.
153 citations
Authors
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Name | H-index | Papers | Citations |
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Magdi H. Yacoub | 109 | 1267 | 52431 |
Virend K. Somers | 106 | 615 | 54203 |
Felix Mitelman | 95 | 578 | 35416 |
Andrzej Slominski | 91 | 469 | 27900 |
Nils Mandahl | 86 | 427 | 25006 |
Fredrik Mertens | 84 | 406 | 28705 |
Enriqueta Felip | 83 | 622 | 53364 |
Pieter E. Postmus | 81 | 384 | 24039 |
Wilhelm Kriz | 73 | 222 | 19335 |
Godefridus J. Peters | 73 | 523 | 28315 |
Jacek Jassem | 73 | 602 | 35976 |
Piotr Rutkowski | 72 | 563 | 42218 |
Thomas Frodl | 70 | 258 | 16469 |
Eric J. Velazquez | 70 | 396 | 27539 |
Argye E. Hillis | 68 | 398 | 22230 |