Institution
Gdańsk Medical University
Education•Gdańsk, Poland•
About: Gdańsk Medical University is a education organization based out in Gdańsk, Poland. It is known for research contribution in the topics: Population & Cancer. The organization has 4893 authors who have published 11216 publications receiving 260523 citations.
Topics: Population, Cancer, Transplantation, Blood pressure, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: Fragment size analysis and selective sequencing of specific fragment sizes can boost ctDNA detection and could complement or provide an alternative to deeper sequencing of cfDNA.
Abstract: Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alterations but have rarely considered the biological properties of plasma cell-free DNA (cfDNA). We hypothesized that differences in fragment lengths of circulating DNA could be exploited to enhance sensitivity for detecting the presence of ctDNA and for noninvasive genomic analysis of cancer. We surveyed ctDNA fragment sizes in 344 plasma samples from 200 patients with cancer using low-pass whole-genome sequencing (0.4×). To establish the size distribution of mutant ctDNA, tumor-guided personalized deep sequencing was performed in 19 patients. We detected enrichment of ctDNA in fragment sizes between 90 and 150 bp and developed methods for in vitro and in silico size selection of these fragments. Selecting fragments between 90 and 150 bp improved detection of tumor DNA, with more than twofold median enrichment in >95% of cases and more than fourfold enrichment in >10% of cases. Analysis of size-selected cfDNA identified clinically actionable mutations and copy number alterations that were otherwise not detected. Identification of plasma samples from patients with advanced cancer was improved by predictive models integrating fragment length and copy number analysis of cfDNA, with area under the curve (AUC) >0.99 compared to AUC 0.91 compared to AUC < 0.5 without fragmentation features. Fragment size analysis and selective sequencing of specific fragment sizes can boost ctDNA detection and could complement or provide an alternative to deeper sequencing of cfDNA.
602 citations
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University of Milano-Bicocca1, Katholieke Universiteit Leuven2, Gdańsk Medical University3, University of Valencia4, University of Milan5, Ghent University6, Charles University in Prague7, University of Glasgow8, University Medical Center Utrecht9, Linköping University10, University of Birmingham11, University of Oslo12, French Institute of Health and Medical Research13, Lund University14, John Radcliffe Hospital15, Tallinn University of Technology16, University Hospital of Lausanne17, University of Lorraine18
TL;DR: This paper aims to demonstrate the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
Abstract: ABPMambulatory blood pressure monitoringACEangiotensin converting enzymeARBangiotensin receptor blockerA-Vatrio-ventricularBBbeta-blockerBPblood pressureCHDcoronary heart diseaseCKDchronic kidney d...
599 citations
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TL;DR: Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated.
593 citations
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01 Jan 1987TL;DR: In this article, the authors used Factor Analysis in QSRR studies relationship between Liquid Chromatographic Retention Data and Partition Coefficients in Studies of Quantitative Structure-Biological Activity Relationships Index.
Abstract: Introduction Nature of Chromatographic Interactions Molecular Interpretation of Distribution Processes in Chromatography Determination of Chromatographic Retention Data for Quantitative Structure-Retention Relationship Studies Methodology of Quantitative Structure-Retention Relationship Analysis Additive Structural Parameters in Quantitative Structure-Retention Relationship Studies Parameters Related to Specific Physicochemical Properties of Solutes Topological Indices as Retention Descriptors Multiparameter Structure-Chromatographic Retention Relationships Application of Factor Analysis in QSRR Studies Relationship Between Liquid Chromatographic Retention Data and Partition Coefficients Chromatographic Retention Data in Studies of Quantitative Structure-Biological Activity Relationships Index.
592 citations
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Memorial Sloan Kettering Cancer Center1, Gdańsk Medical University2, Institut Gustave Roussy3, Pontifícia Universidade Católica do Rio Grande do Sul4, Karolinska University Hospital5, Durham University6, American University of Beirut7, Brighton and Sussex Medical School8, Peter MacCallum Cancer Centre9, BC Cancer Agency10, University of Texas MD Anderson Cancer Center11, European Institute of Oncology12, Ludwig Maximilian University of Munich13, University of Sydney14, Sheba Medical Center15, Harvard University16, University of Michigan17, Institut Jules Bordet18, University of California, San Francisco19, Indiana University20, Martin Luther University of Halle-Wittenberg21, Cardiff University22, Peking Union Medical College23
TL;DR: Advanced Breast Cancer (ABC) is a treatable but still generally incurable disease, although the range is wide, and survival may be longer for patients treated in specialized institutions and within each country.
552 citations
Authors
Showing all 4927 results
Name | H-index | Papers | Citations |
---|---|---|---|
Magdi H. Yacoub | 109 | 1267 | 52431 |
Virend K. Somers | 106 | 615 | 54203 |
Felix Mitelman | 95 | 578 | 35416 |
Andrzej Slominski | 91 | 469 | 27900 |
Nils Mandahl | 86 | 427 | 25006 |
Fredrik Mertens | 84 | 406 | 28705 |
Enriqueta Felip | 83 | 622 | 53364 |
Pieter E. Postmus | 81 | 384 | 24039 |
Wilhelm Kriz | 73 | 222 | 19335 |
Godefridus J. Peters | 73 | 523 | 28315 |
Jacek Jassem | 73 | 602 | 35976 |
Piotr Rutkowski | 72 | 563 | 42218 |
Thomas Frodl | 70 | 258 | 16469 |
Eric J. Velazquez | 70 | 396 | 27539 |
Argye E. Hillis | 68 | 398 | 22230 |