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Showing papers by "General Electric published in 2004"


Journal ArticleDOI
TL;DR: Langtry et al. as discussed by the authors developed a new correlation-based transition model based strictly on local variables, which is compatible with modern computational fluid dynamics (CFD) approaches, such as unstructured grids and massive parallel execution.
Abstract: A new correlation-based transition model has been developed, which is based strictly on local variables. As a result, the transition model is compatible with modern computational fluid dynamics (CFD) approaches, such as unstructured grids and massive parallel execution. The model is based on two transport equations, one for intermittency and one for the transition onset criteria in terms of momentum thickness Reynolds number. The proposed transport equations do not attempt to model the physics of the transition process (unlike, e.g., turbulence models) but form a framework for the implementation of correlation-based models into general-purpose CFD methods. Part I (this part) of this paper gives a detailed description of the mathematical formulation of the model and some of the basic test cases used for model validation, including a two-dimensional turbine blade. Part II (Langtry, R. B., Menter, F. R., Likki, S. R., Suzen, Y. B., Huang, P. G., and Volker, S., 2006, ASME J. Turbomach., 128(3), pp. 423–434) of the paper details a significant number of test cases that have been used to validate the transition model for turbomachinery and aerodynamic applications. The authors believe that the current formulation is a significant step forward in engineering transition modeling, as it allows the combination of correlation-based transition models with general purpose CFD codes.

1,131 citations


Journal ArticleDOI
TL;DR: An edit-distance algorithm for shock graphs that finds the optimal deformation path in polynomial time is employed and gives intuitive correspondences for a variety of shapes and is robust in the presence of a wide range of visual transformations.
Abstract: This paper presents a novel framework for the recognition of objects based on their silhouettes. The main idea is to measure the distance between two shapes as the minimum extent of deformation necessary for one shape to match the other. Since the space of deformations is very high-dimensional, three steps are taken to make the search practical: 1) define an equivalence class for shapes based on shock-graph topology, 2) define an equivalence class for deformation paths based on shock-graph transitions, and 3) avoid complexity-increasing deformation paths by moving toward shock-graph degeneracy. Despite these steps, which tremendously reduce the search requirement, there still remain numerous deformation paths to consider. To that end, we employ an edit-distance algorithm for shock graphs that finds the optimal deformation path in polynomial time. The proposed approach gives intuitive correspondences for a variety of shapes and is robust in the presence of a wide range of visual transformations. The recognition rates on two distinct databases of 99 and 216 shapes each indicate highly successful within category matches (100 percent in top three matches), which render the framework potentially usable in a range of shape-based recognition applications.

773 citations


Journal ArticleDOI
Nguyen Q. Minh1
TL;DR: In this paper, the authors discuss and summarize the SOFC's features and provide an overview of this technology's potential applications, including flexibility in cell and stack designs, manufacturing processes, and power plant sizes.

765 citations


Journal ArticleDOI
TL;DR: The distance-driven framework for projection and backprojection is extended to three dimensions and its application to cone beam reconstruction is demonstrated and experimental results are presented to demonstrate the computational performance, the artefact characteristics and the noise-resolution characteristics of thedistance-driven method in three dimensions.
Abstract: Projection and backprojection are operations that arise frequently in tomographic imaging. Recently, we proposed a new method for projection and backprojection, which we call distance-driven, and that offers low arithmetic cost and a highly sequential memory access pattern. Furthermore, distance-driven projection and backprojection avoid several artefact-inducing approximations characteristic of some other methods. We have previously demonstrated the application of this method to parallel and fan beam geometries. In this paper, we extend the distance-driven framework to three dimensions and demonstrate its application to cone beam reconstruction. We also present experimental results to demonstrate the computational performance, the artefact characteristics and the noise-resolution characteristics of the distance-driven method in three dimensions.

501 citations


Journal ArticleDOI
TL;DR: In this article, the authors discuss the current status, development needs and future potential to build or engineer nanostructured materials for dielectric applications in the electrical power industry.
Abstract: While specialty applications of nanotechnology in the photonics and electronics areas have seen a tremendous growth in the past several years, the use of nanodielectrics in the electrical industry (high power density and high voltage) has not shown the same level of activity. In addition to a review of nanodielectrics, we discuss in this paper, our perspective on the current status, development needs and future potential to build or engineer nanostructured materials for dielectric applications in the electrical power industry. Short and long-term future research and development needs are considered from the point of view of industrial applications.

489 citations


Journal ArticleDOI
TL;DR: Menter et al. as mentioned in this paper proposed a new correlation-based transition model based on local variables, which is compatible with modern computational fluid dynamics (CFD) methods using unstructured grids and massive parallel execution.
Abstract: A new correlation-based transition model has been developed, which is built strictly on local variables. As a result, the transition model is compatible with modern computational fluid dynamics (CFD) methods using unstructured grids and massive parallel execution. The model is based on two transport equations, one for the intermittency and one for the transition onset criteria in terms of momentum thickness Reynolds number. The proposed transport equations do not attempt to model the physics of the transition process (unlike, e.g., turbulence models), but form a framework for the implementation of correlation-based models into general-purpose CFD methods. Part I of this paper (Menter, F. R., Langtry, R. B., Likki, S. R., Suzen, Y. B., Huang, P. G., and Volker, S., 2006, ASME J. Turbomach., 128(3), pp. 413–422) gives a detailed description of the mathematical formulation of the model and some of the basic test cases used for model validation. Part II (this part) details a significant number of test cases that have been used to validate the transition model for turbomachinery and aerodynamic applications, including the drag crisis of a cylinder, separation-induced transition on a circular leading edge, and natural transition on a wind turbine airfoil. Turbomachinery test cases include a highly loaded compressor cascade, a low-pressure turbine blade, a transonic turbine guide vane, a 3D annular compressor cascade, and unsteady transition due to wake impingement. In addition, predictions are shown for an actual industrial application, namely, a GE low-pressure turbine vane. In all cases, good agreement with the experiments could be achieved and the authors believe that the current model is a significant step forward in engineering transition modeling.

436 citations


Journal ArticleDOI
TL;DR: In this paper, a modified version of the Eshelby tensor tensor for nano-inclusions is presented, where the elastic state of an embedded inclusion is modified by incorporating the previously excluded surface/interface Stresses, tension and energies.
Abstract: The classical formulation of Eshelby (Proc. Royal Society, A241, p. 376, 1957) for embedded inclusions is revisited and modified by incorporating the previously excluded surface/interface Stresses, tension and energies. The latter effects come into prominence at inclusion sizes in the nanometer range. Unlike the classical result, our modified formulation renders the elastic state of an embedded inclusion size-dependent making possible the extension of Eshelby's original formalism to nano-inclusions. We present closed-form expressions of the modified Eshelby's tensor for spherical and cylindrical inclusions. Eshelby original conjecture that only inclusions of the ellipsoid family admit uniform elastic state under uniform stress-free transformation strains must be modified in the context of coupled surface/interface-bulk elasticity. We reach an interesting conclusion in that only inclusions with a constant curvature admit a uniform elastic stale, thus restrict-ing this remarkable property only to spherical and cylindrical inclusions. As an immediate consequence of the derivation of modified size-dependent Eshelby tensor for nano-inclusions, we also formulate the overall size-dependent bulk modulus of a composite containing such inclusions. Further applications are illustrated for size-dependent stress concentrations on voids and opto-electronic properties of embedded quantum dots.

433 citations


Journal ArticleDOI
TL;DR: 4D PET/CT is clinically a feasible method, to correct for respiratory motion artifacts in PET/ CT imaging of the thorax, and can reduce smearing, improve the accuracy in PET-CT co-registration, and increase the measured SUV.
Abstract: We have reported in our previous studies on the methodology, and feasibility of 4D-PET (Gated PET) acquisition, to reduce respiratory motion artifact in PET imaging of the thorax. In this study, we expand our investigation to address the problem of respiration motion in PET/CT imaging. The respiratory motion of four lung cancer patients were monitored by tracking external markers placed on the thorax. A 4D-CT acquisition was performed using a "step-and-shoot" technique, in which computed tomography (CT) projection data were acquired over a complete respiratory cycle at each couch position. The period of each CT acquisition segment was time stamped with an "x-ray ON" signal, which was recorded by the tracking system. 4D-CT data were then sorted into 10 groups, according to their corresponding phase of the breathing cycle. 4D-PET data were acquired in the gated mode, where each breathing cycle was divided into ten 0.5 s bins. For both CT and PET acquisitions, patients received audio prompting to regularize breathing. The 4D-CT and 4D-PET data were then correlated according to respiratory phase. The effect of 4D acquisition on improving the co-registration of PET and CT images, reducing motion smearing, and consequently increase the quantitation of the SUV, were investigated. Also, quantitation of the tumor motions in PET, and CT, were studied and compared. 4D-PET with matching phase 4D-CTAC showed an improved accuracy in PET-CT image co-registration of up to 41%, compared to measurements from 4D-PET with clinical-CTAC. Gating PET data in correlation with respiratory motion reduced motion-induced smearing, thereby decreasing the observed tumor volume, by as much as 43%. 4D-PET lesions volumes showed a maximum deviation of 19% between clinical CT and phase- matched 4D-CT attenuation corrected PET images. In CT, 4D acquisition resulted in increasing the tumor volume in two patients by up to 79%, and decreasing it in the other two by up to 35%. Consequently, these corrections have yielded an increase in the measured SUV by up to 16% over the clinical measured SUV, and 36% over SUV's measured in 4D-PET with clinical-CT Attenuation Correction (CTAC) SUV's. Quantitation of the maximum tumor motion amplitude, using 4D-PET and 4D-CT, showed up to 30% discrepancy between the two modalities. We have shown that 4D PET/CT is clinically a feasible method, to correct for respiratory motion artifacts in PET/CT imaging of the thorax. 4D PET/CT acquisition can reduce smearing, improve the accuracy in PET-CT co-registration, and increase the measured SUV. This should result in an improved tumor assessment for patients with lung malignancies.

359 citations


Journal ArticleDOI
TL;DR: Recent advances in the basic science of brain iron metabolism, the clinical understanding of neurodegenerative diseases and in MRI technology, suggest that iron‐dependent MR imaging may soon provide biomarkers capable of characterizing the presence and progression of important neurological disorders.
Abstract: The brain has an unusually high concentration of iron, which is distributed in an unusual pattern unlike that in any other organ. The physiological role of this iron and the reasons for this pattern of distribution are not yet understood. There is increasing evidence that several neurodegenerative diseases are associated with altered brain iron metabolism. Understanding these dysmetabolic conditions may provide important information for their diagnosis and treatment. For many years the iron distribution in the human brain could be studied effectively only under postmortem conditions. This situation was changed dramatically by the finding that T2-weighted MR imaging at high field strength (initially 1.5 T) appears to demonstrate the pattern of iron distribution in normal brains and that this imaging technique can detect changes in brain iron concentrations associated with disease states. Up to the present time this imaging capability has been utilized in many research applications but it has not yet been widely applied in the routine diagnosis and management of neurodegenerative disorders. However, recent advances in the basic science of brain iron metabolism, the clinical understanding of neurodegenerative diseases and in MRI technology, particularly in the availability of clinical scanners operating at the higher field strength of 3 T, suggest that iron-dependent MR imaging may soon provide biomarkers capable of characterizing the presence and progression of important neurological disorders. Such biomarkers may be of crucial assistance in the development and utilization of effective new therapies for Alzheimer's and Parkinson's diseases, multiple sclerosis and other iron-related CNS disorders which are difficult to diagnose and treat. Copyright © 2004 John Wiley & Sons, Ltd.

328 citations


Proceedings ArticleDOI
26 Jan 2004
TL;DR: In this paper, the effect of chip packages on junction to board thermal resistance was compared for both SiC and Sapphire chips, and a conceptual LED illumination system was chosen and CFD models were created to determine the availability and limitations of passive air-cooling.
Abstract: Light emitting diodes, LEDs, historically have been used for indicators and produced low amounts of heat. The introduction of high brightness LEDs with white light and monochromatic colors have led to a movement towards general illumination. The increased electrical currents used to drive the LEDs have focused more attention on the thermal paths in the developments of LED power packaging. The luminous efficiency of LEDs is soon expected to reach over 80 lumens/W, this is approximately 6 times the efficiency of a conventional incandescent tungsten bulb. Thermal management for the solid-state lighting applications is a key design parameter for both package and system level. Package and system level thermal management is discussed in separate sections. Effect of chip packages on junction to board thermal resistance was compared for both SiC and Sapphire chips. The higher thermal conductivity of the SiC chip provided about 2 times better thermal performance than the latter, while the under-filled Sapphire chip package can only catch the SiC chip performance. Later, system level thermal management was studied based on established numerical models for a conceptual solid-state lighting system. A conceptual LED illumination system was chosen and CFD models were created to determine the availability and limitations of passive air-cooling.

247 citations


Journal ArticleDOI
TL;DR: Respiratory motion was in most cases consistent betweenPET and CT sessions, thereby improving both the attenuation correction of PET images, and co-registration of PET and CT images, on a phase-to-phase basis.
Abstract: We report on the variability of the respiratory motion during 4D-PET/CT acquisition. The respiratory motion for five lung cancer patients was monitored by tracking external markers placed on the abdomen. CT data were acquired over an entire respiratory cycle at each couch position. The x-ray tube status was recorded by the tracking system, for retrospective sorting of the CT data as a function of respiration phase. Each respiratory cycle was sampled in ten equal bins. 4D-PET data were acquired in gated mode, where each breathing cycle was divided into ten 500 ms bins. For both CT and PET acquisition, patients received audio prompting to regularize breathing. The 4D-CT and 4D-PET data were then correlated according to their respiratory phases. The respiratory periods, and average amplitude within each phase bin, acquired in both modality sessions were then analyzed. The average respiratory motion period during 4D-CT was within 18% from that in the 4D-PET sessions. This would reflect up to 1.8% fluctuation in the duration of each 4D-CT bin. This small uncertainty enabled good correlation between CT and PET data, on a phase-to-phase basis. Comparison of the average-amplitude within the respiration trace, between 4D-CT and 4D- PET, on a bin-by-bin basis show a maximum deviation of approximately 15%. This study has proved the feasibility of performing 4D-PET/CT acquisition. Respiratory motion was in most cases consistent between PET and CT sessions, thereby improving both the attenuation correction of PET images, and co-registration of PET and CT images. On the other hand, in two patients, there was an increased partial irregularity in their breathing motion, which would prevent accurately correlating the corresponding PET and CT images.

Patent
08 Jun 2004
TL;DR: In this paper, a hybrid DACRS and Swozzle burners are combined to provide high mixing ability of an axial flowing counter rotating vane swirler with good dynamic flame stability characteristics of a bluff center body.
Abstract: A hybrid structure that combines characteristics of the DACRS and Swozzle burners to provide the high mixing ability of an axial flowing counter rotating vane swirler with good dynamic flame stability characteristics of a bluff center body.

Journal ArticleDOI
20 Sep 2004
TL;DR: The past and recent progress on the worldwide development of industrial-grade superconducting rotating machines utilizing low-temperature superconductor and HTS field windings is reviewed and an outlook on the benefits and opportunities of this new technology is provided.
Abstract: Superconducting rotating machines have looked promising since multifilamentary niobium-titanium (NbTi) superconductors became available in the mid-1960s. Both dc homopolar and ac synchronous machines were successfully tested from the 1970s to the 1990s. Three different 70-MW generators were recently demonstrated by the SuperGM project in Japan. However, economic considerations with respect to competitive cost combined with the requirement for liquid helium cooling did not make these machines commercially attractive. On the other hand, high-temperature superconductors (HTSs) can operate at much higher temperatures (30-40 K), providing much larger thermal margin and simpler cooling systems. This refrigeration advantage has provided new impetus to the development of such machines for commercial applications. In the last few years, a number of superconducting rotating machines with HTS field windings have been demonstrated and several projects are currently transitioning to advanced development stages. HTS machines with ratings from a few kilowatts to several megawatts have been demonstrated in the United States and Europe. Currently, large high-torque ship propulsion motors, large generator prototypes, and synchronous condensers are under development and are expected to be commercially available in the next few years. Prospects for improved life cycle cost, smaller size, less weight, and higher efficiency benefits are providing incentives for the development of these larger rating HTS machines. This paper reviews the past and recent progress on the worldwide development of industrial-grade superconducting rotating machines utilizing low-temperature superconductor and HTS field windings and provides an outlook on the benefits and opportunities of this new technology.

Patent
10 Jun 2004
TL;DR: In this article, a method for detecting ice on a wind turbine having a rotor and one or more rotor blades each having blade roots includes monitoring meteorological conditions relating to icing conditions and monitoring the physical characteristics of the wind turbine in operation.
Abstract: A method for detecting ice on a wind turbine having a rotor and one or more rotor blades each having blade roots includes monitoring meteorological conditions relating to icing conditions and monitoring one or more physical characteristics of the wind turbine in operation that vary in accordance with at least one of the mass of the one or more rotor blades or a mass imbalance between the rotor blades. The method also includes using the one or more monitored physical characteristics to determine whether a blade mass anomaly exists, determining whether the monitored meteorological conditions are consistent with blade icing; and signaling an icing-related blade mass anomaly when a blade mass anomaly is determined to exist and the monitored meteorological conditions are determined to be consistent with icing.

Patent
29 Mar 2004
TL;DR: In this article, a system for co-production of hydrogen and electrical energy comprising a reformer configured to receive reformer fuel and steam and produce a reformate rich in hydrogen is presented.
Abstract: A system for co-production of hydrogen and electrical energy comprising a reformer configured to receive a reformer fuel and steam and produce a reformate rich in hydrogen. The system further comprises a separation unit in fluid communication with the reformer wherein the separation unit is configured to receive the reformate to separate hydrogen from the reformate and produce an off gas. The system also includes a combustor configured to receive a fuel for combustion and produce heat energy and a hot compressed gas, wherein the combustor is coupled with the reformer. A gas turbine expands the hot compressed gas and produces electrical energy and an expanded gas; wherein at least a part of the heat energy from the combustor is used to produce the reformate in the reformer.

Journal ArticleDOI
TL;DR: A columnar-grain variant of single-crystal RENE N4 has been directionally solidified over a range of conditions in order to assess the possible benefits of the use of liquid metal-enhanced cooling for large cross-sectional castings as discussed by the authors.
Abstract: A columnar-grain variant of single-crystal RENE N4 has been directionally solidified (DS) over a range of conditions in order to assess the possible benefits of the use of liquid metal-enhanced cooling for large cross-sectional castings. Castings were solidified at a rate of 2.5 mm/min using conventional radiation cooling and at rates between 2.5 and 8.5 mm/min using liquid-metal cooling (LMC) with tin as a cooling medium. Thermocouples inserted in the casting directly measured thermal gradients during solidification. The LMC process exhibited higher gradients at all withdrawal rates. The higher thermal gradients resulted in a refined structure measurable by the finer dendrite-arm spacing. Additionally, the conventionally cast material exhibited several freckle-type defects, while none were observed in the liquid-metal-cooled castings.

Journal ArticleDOI
TL;DR: Here it is shown how time-domain thermoreflectance can be used to image the thermal conductivity of the cross-section of a Nb–Ti–Cr–Si diffusion multiple, and thereby demonstrate rapid and quantitative measurements of thermal transport properties for combinatorial studies of materials.
Abstract: Combinatorial methods offer an efficient approach for the development of new materials. Methods for generating combinatorial samples of materials, and methods for characterizing local composition and structure by electron microprobe analysis and electron-backscatter diffraction are relatively well developed. But a key component for combinatorial studies of materials is high-spatial-resolution measurements of the property of interest, for example, the magnetic, optical, electrical, mechanical or thermal properties of each phase, composition or processing condition. Advances in the experimental methods used for mapping these properties will have a significant impact on materials science and engineering. Here we show how time-domain thermoreflectance can be used to image the thermal conductivity of the cross-section of a Nb-Ti-Cr-Si diffusion multiple, and thereby demonstrate rapid and quantitative measurements of thermal transport properties for combinatorial studies of materials. The lateral spatial resolution of the technique is 3.4 microm, and the time required to measure a 100 x 100 pixel image is approximately 1 h. The thermal conductivity of TiCr(2) decreases by a factor of two in crossing from the near-stoichiometric side of the phase to the Ti-rich side; and the conductivity of (Ti,Nb)(3)Si shows a strong dependence on crystalline orientation.

Patent
Hua Wang1
12 Feb 2004
TL;DR: In this article, weatherable multilayer articles comprising a coating layer comprising a block copolyestercarbonate comprising structural units derived from at least one 1,3-dihydroxybenzene and at least 1 aromatic dicarboxylic acid are presented.
Abstract: Disclosed are weatherable multilayer articles comprising (i) a coating layer comprising a block copolyestercarbonate comprising structural units derived from at least one 1,3-dihydroxybenzene and at least one aromatic dicarboxylic acid, (ii) a second layer comprising a polymer comprising carbonate structural units, (iii) a substrate layer comprising a polypropylene, and (iv) at least one adhesive layer comprising the reaction product of an amine-functionalized polypropylene and a polyurethane, wherein the coating layer is in contiguous contact with the second layer, and the adhesive layer is in contiguous contact with the second layer and the substrate layer. Also disclosed is a method for making the multilayer article.

Patent
11 Aug 2004
TL;DR: In this paper, the authors present a system and method for facilitating in-home living by monitoring and analyzing in home activities, and thereby implementing services for facilitating such living, which includes an integrated portfolio of active and/or passive sensors for monitoring activities of an individual, and an analyzing system for synthesizing and analyzing signals from the sensors for thereby assessing a status of the individual and inferring the individual's quality of life.
Abstract: A system and method for facilitating in-home living by monitoring and analyzing in-home activities, and thereby implementing services for facilitating such living. The system includes an integrated portfolio of active and/or passive sensors for monitoring activities of an individual, and an analyzing system for synthesizing and analyzing signals from the sensors for thereby assessing a status of the individual and inferring the individual's quality of life. The system further includes a decision making system for generating an output based upon the assessment, and an activation system for activating processes to respond to the decision making.

Journal ArticleDOI
TL;DR: A 32‐element receive‐coil array and a volumetric paradigm that address the SNR challenge at high accelerations by maximally exploiting multidimensional acceleration in conjunction with noise averaging is presented.
Abstract: The improvement of MRI speed with parallel acquisition is ultimately an SNR-limited process. To offset acquisition- and reconstruction-related SNR losses, practical parallel imaging at high accelerations should include the use of a many-element array with a high intrinsic signal-to-noise ratio (SNR) and spatial-encoding capability, and an advantageous imaging paradigm. We present a 32-element receive-coil array and a volumetric paradigm that address the SNR challenge at high accelerations by maximally exploiting multidimensional acceleration in conjunction with noise averaging. Geometric details beyond an initial design concept for the array were determined with the guidance of simulations. Imaging with the support of 32-channel data acquisition systems produced in vivo results with up to 16-fold acceleration, including images from rapid abdominal and MRA studies.


Patent
25 Aug 2004
TL;DR: In this article, a system and method for hybrid tracking in surgical navigation is disclosed, where a plurality of tracking technologies are used in a medical procedure where a reconciler determines an active tracking technology during the medical procedure.
Abstract: A system and method for hybrid tracking in surgical navigation is disclosed. A plurality of tracking technologies is used in a medical procedure where a reconciler determines an active tracking technology. The reconciler determines the active tracking technology during the medical procedure. A switch may then activate one or more tracking technologies. The determination of which technology or technologies are to be activated may be based, for example, on metrics measured by each of the technologies, such as an accuracy measurement. In addition, a display may present representations based on at least data obtained by one or more of the tracking technologies. The switch may employ weighted switching to gradually switch the display of a first representation corresponding to a first tracking technology to the display of a second representation corresponding to a second tracking technology, where the first technology is deactivated and the second technology is activated.

Journal ArticleDOI
TL;DR: In this paper, the magnetic characteristics of surface-mounted permanent magnet machines are analyzed and modeled in terms of the magnetic material properties and the motor dimensions, and the results show that the errors between the FEM results and analytical predictions are less than 7% for nonsaturated tooth flux and less than 17% for the saturated case.
Abstract: In this paper the magnetic characteristics of surface-mounted permanent-magnet machines are analyzed and modeled. The air-gap and zigzag leakage fluxes are analytically expressed in terms of the magnetic material properties and the motor dimensions. Both factors are essential quantities for the accurate prediction of the flux distribution within the machine and of the machine torque. Therefore, they are desired for the purpose of machine design and optimization. In order to evaluate the validity of the proposed models, the finite-element method (FEM) analysis is used. The results show that the errors between the FEM results and analytical predictions are less than 7% for the nonsaturated tooth flux and less than 17% for the saturated case. Finally, the models are applied to a novel permanent-magnet machine design.

Journal ArticleDOI
TL;DR: A novel approach to building hybrid simulations in which some processes are simulated discretely, while other processes are handled in a continuous simulation by differential equations, which preserves the stochastic behavior of cellular pathways, yet enables scaling to large populations of molecules.
Abstract: Motivation: To be valuable to biological or biomedical research, in silico methods must be scaled to complex pathways and large numbers of interacting molecular species. The correct method for performing such simulations, discrete event simulation by Monte Carlo generation, is computationally costly for large complex systems. Approximation of molecular behavior by continuous models fails to capture stochastic behavior that is essential to many biological phenomena. Results: We present a novel approach to building hybrid simulations in which some processes are simulated discretely, while other processes are handled in a continuous simulation by differential equations. This approach preserves the stochastic behavior of cellular pathways, yet enables scaling to large populations of molecules. We present an algorithm for synchronizing data in a hybrid simulation and discuss the trade-offs in such simulation. We have implemented the hybrid simulation algorithm and have validated it by simulating the statistical behavior of the well-known lambda phage switch. Hybrid simulation provides a new method for exploring the sources and nature of stochastic behavior in cells. Supplementary information: The SBML file for the lambda phage tests will be made available at the OUP site.

Patent
27 Sep 2004
TL;DR: In this article, a double-sided stator with an inner stator and an outer stator side is proposed for wind turbine and ship propulsion purposes, where the inner rotor core is concentrically disposed between the outer rotor core and the main rotor core.
Abstract: Machines useful for wind turbine and ship propulsion purposes include a wind turbine generator or a ship propulsion motor with two concentric air gaps. In one embodiment, the machine includes a rotor with an inner rotor core and an outer rotor core; and a double-sided stator with an inner stator side and an outer stator side. The double-sided stator is concentrically disposed between the inner rotor core and the outer rotor core.

Patent
18 Oct 2004
TL;DR: A combination master-slave supervisory command and data acquisition (SCADA) architecture together with distributed databases local to the data producing device within a wind farm provide functionality for real-time monitoring and control as well as secondary data processing and/or remote user access.
Abstract: Wind turbine generator wind farm systems to collect data for use for wind farm control. A combination master-slave supervisory command and data acquisition (SCADA) architecture together with distributed databases local to the data producing device within a wind farm provide functionality for real-time monitoring and control as well as secondary data processing and/or remote user access. The architecture facilitates approximately real-time monitoring and control of devices in the wind farm both locally and remotely while also facilitating reliable archiving of operational data of individual wind turbines as well as totalized wind farm data.

Journal ArticleDOI
TL;DR: Imaging of PMMA tubing filled with MICROFIL shows that even vessels below 20 microm in diameter are detectable and that diameter estimation of vessels based on thresholding is possible with a precision of 2-3 pixels.
Abstract: Obtaining three-dimensional geometrical data of vascular systems is of major importance to a number of research areas in medicine and biology. Examples are the characterization of tumor vasculature, modeling blood flow, or genetic effects on vascular development. The performance of the General Electric Medical Systems MS8 microCT scanner is examined in the context of these applications. The system is designed to acquire high-resolution images of specimens up to 5 cm in diameter. A maximum resolution of 38 lp/mm at the 10% modulation transfer function level or 22 microm full width at half maximum of the plane spread function can be achieved with 8.5 microm voxels and a 17 mm field of view. Three different contrast agents are discussed and applied for imaging of small animal vasculature: corrosion casting material Batson's No. 17 with an added lead pigment, silicon rubber MICROFIL MV122, and a suspension of barium sulfate (Baritop) in gelatin. Contrast for all of these agents was highly variable in different vessels as well as within the same vessel. Imaging of PMMA tubing filled with MICROFIL shows that even vessels below 20 microm in diameter are detectable and that diameter estimation of vessels based on thresholding is possible with a precision of 2-3 pixels.


Proceedings ArticleDOI
24 Aug 2004
TL;DR: In this article, several new reliability importance indices are proposed and defined, which can be directly calculated from the simulation results and their limiting values are traditional reliability importance index, and examples are provided to illustrate the application of the proposed importance indices.
Abstract: Reliability importance indices are valuable in establishing direction and prioritization of actions related to an upgrading effort (reliability improvement) in system design, or suggesting the most efficient way to operate and maintain system status. Existing indices are calculated through analytical approaches, and application of these indices to complex repairable systems may be intractable. Complex repairable systems are being increasingly seen, and issues related to analytical system reliability and availability solutions are well known. To overcome this intractability, discrete event simulation, through the use of reliability block diagrams (RBD), is often used to obtain numerical system reliability characteristics. Traditional use of simulation results provides no easy way to compute reliability importance indices. To bridge this gap, several new reliability importance indices are proposed and defined in this paper. These indices can be directly calculated from the simulation results and their limiting values are traditional reliability importance indices. Examples are provided to illustrate the application of the proposed importance indices.

Patent
31 Mar 2004
TL;DR: In this paper, the projection images of an object of interest are acquired from different locations, such as by moving an X-ray source along an arbitrary imaging trajectory between emissions or by individually activating different x-ray sources located at different locations relative to the object in interest, and reconstructed to generate a 3D dataset representative of the object from which one or more volumes may be selected for visualization and display.
Abstract: Techniques are provided for generating three-dimensional images, such as may be used in mammography. In accordance with these techniques, projection images of an object of interest are acquired from different locations, such as by moving an X-ray source along an arbitrary imaging trajectory between emissions or by individually activating different X-ray sources located at different locations relative to the object of interest. The projection images may be reconstructed to generate a three-dimensional dataset representative of the object from which one or more volumes may be selected for visualization and display. Additional processing steps may occur throughout the image chain, such as for pre-processing the projection images or post-processing the three-dimensional dataset.