Georgetown University

About: Georgetown University is a education organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Breast cancer. The organization has 23377 authors who have published 43718 publications receiving 1748598 citations. The organization is also known as: GU & Georgetown.

Relationship of Mediterranean Diet and Caloric Intake to Phenoconversion in Huntington Disease

Abstract: Importance Adherence to Mediterranean-type diet (MeDi) may delay onset of Alzheimer and Parkinson diseases. Whether adherence to MeDi affects time to phenoconversion in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown. Objectives To determine if MeDi modifies the time to clinical onset of HD (phenoconversion) in premanifest carriers participating in Prospective Huntington at Risk Observational Study (PHAROS), and to examine the effects of body mass index and caloric intake on time to phenoconversion. Design, Setting, and Participants A prospective cohort study of 41 Huntington study group sites in the United States and Canada involving 1001 participants enrolled in PHAROS between July 1999 and January 2004 who were followed up every 9 months until 2010. A total of 211 participants aged 26 to 57 years had an expanded CAG repeat length (≥37). Exposure A semiquantitative food frequency questionnaire was administered 33 months after baseline. We calculated daily gram intake for dairy, meat, fruit, vegetables, legumes, cereals, fish, monounsaturated and saturated fatty acids, and alcohol and constructed MeDi scores (0-9); higher scores indicate higher adherence. Demographics, medical history, body mass index, and Unified Huntington's Disease Rating Scale (UHDRS) score were collected. Main Outcome and Measure Cox proportional hazards regression models to determine the association of MeDi and phenoconversion. Results Age, sex, caloric intake, education status, and UHDRS motor scores did not differ among MeDi tertiles (0-3, 4-5, and 6-9). The highest body mass index was associated with the lowest adherence to MeDi. Thirty-one participants phenoconverted. In a model adjusted for age, CAG repeat length, and caloric intake, MeDi was not associated with phenoconversion ( P for trend = 0.14 for tertile of MeDi, and P = .22 for continuous MeDi). When individual components of MeDi were analyzed, higher dairy consumption (hazard ratio, 2.36; 95% CI, 1.0-5.57; P = .05) and higher caloric intake ( P = .04) were associated with risk of phenoconversion. Conclusions and Relevance MeDi was not associated with phenoconversion; however, higher consumption of dairy products had a 2-fold increased risk and may be a surrogate for lower urate levels (associated with faster progression in manifest HD). Studies of diet and energy expenditure in premanifest HD may provide data for interventions to modify specific components of diet that may delay the onset of HD.

The effects of man made gaps on germination, early survival, and morphology of Chlorocardium rodiei seedlings in Guyana.

Abstract: Germination success of Chlorocardium rodiei is low in large gaps. High light levels, however are beneficial for the survival of seedlings. (Partial) removal of cotyledons has a large negative impact on survival especially under low light conditions. Seedlings from large gaps are larger but not taller than those from the understorey, due to differential internode growth. Although growth of seedlings is improved by higher light levels caused for example by logging, great care should be taken with logging intensity, which may increase seed mortality.

Sorting with Asymmetric Read and Write Costs

Abstract: Emerging memory technologies have a significant gap between the cost, both in time and in energy, of writing to memory versus reading from memory. In this paper we present models and algorithms that account for this difference, with a focus on write-efficient sorting algorithms. First, we consider the PRAM model with asymmetric write cost, and show that sorting can be performed in O(n) writes, O(n log n) reads, and logarithmic depth (parallel time). Next, we consider a variant of the External Memory (EM) model that charges k > 1 for writing a block of size B to the secondary memory, and present variants of three EM sorting algorithms (multi-way merge sort, sample sort, and heap sort using buffer trees) that asymptotically reduce the number of writes over the original algorithms, and perform roughly k block reads for every block write. Finally, we define a variant of the Ideal-Cache model with asymmetric write costs, and present write-efficient,cache-oblivious parallel algorithms for sorting, FFTs, and matrix multiplication. Adapting prior bounds for work-stealing and parallel-depth-first schedulers to the asymmetric setting, these yield provably good bounds for parallel machines with private caches or with a shared cache, respectively.

Importance of Lifestyle Modification on Cardiovascular Risk Reduction: COUNSELING STRATEGIES TO MAXIMIZE PATIENT OUTCOMES.

Abstract: This commentary builds on the unhealthy lifestyle habits, population health, risk factors as harbingers of cardiovascular disease, current provider counseling practices, assessing patient readiness to change, and research-based interventions to facilitate behavior change (eg, the 5A's, motivational interviewing, and overcoming inertia with downscaled goals).