Georgia State University

About: Georgia State University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13988 authors who have published 35895 publications receiving 1164332 citations. The organization is also known as: GSU & Georgia State.

Soft design science methodology

Abstract: This paper proposes and evaluates a soft systems approach to design science research. Soft Design Science provides an approach to the development of new ways to improve human organizations, especially with consideration for social aspects, through the activities of design, development, instantiation, evaluation and evolution of a technological artifact. The Soft Design Science approach merges the common design science research process (design, build-artifact, evaluation) together with the iterative soft systems methodology. The design-build artifact-evaluation process is iterated until the specific requirements are met. The generalized requirements are adjusted as the process continues to keep alignment with the specific requirements. In the end, the artifact represents a general solution to a class of problems shown to operate in one instance of that class of problems. The proposed methodology is evaluated by an analysis of how it differs from, and could have informed and improved, a published design science study, which used a design-oriented action research method.

Centrality dependence of π+/-, K+/-, p, and p̄ production from √sNN = 130 GeV Au + Au collisions at RHIC

Abstract: Identified ${\ensuremath{\pi}}^{+/\ensuremath{-}}$, ${K}^{+/\ensuremath{-}}$, $p$, and $\overline{p}$ transverse momentum spectra at midrapidity in $\sqrt{{s}_{\mathrm{NN}}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}130\phantom{\rule{0ex}{0ex}}\mathrm{GeV}\phantom{\rule{0ex}{0ex}}\mathrm{Au}+\mathrm{Au}$ collisions were measured by the PHENIX experiment at RHIC as a function of collision centrality. Average transverse momenta increase with the number of participating nucleons in a similar way for all particle species. Within errors, all midrapidity particle yields per participant are found to be increasing with the number of participating nucleons. There is an indication that ${K}^{+/\ensuremath{-}}$, $p$, and $\overline{p}$ yields per participant increase faster than the ${\ensuremath{\pi}}^{+/\ensuremath{-}}$ yields. In central collisions at high transverse momenta $({p}_{T}\ensuremath{\gtrsim}2\mathrm{GeV}/c)$, $\overline{p}$ and $p$ yields are comparable to the ${\ensuremath{\pi}}^{+/\ensuremath{-}}$ yields.

Changing patterns in IT skill sets 1988-2003: a content analysis of classified advertising

Abstract: This paper examines trends in required job skills for IT professionals Through an empirical study of classified job advertising for IT professionals over the past 17 years, we evaluate whether the observed trends support earlier predictions offered by researchers who sought to anticipate future job and skill demands (Leitheiser 1992; Trauth, Farwell, & Lee 1993) Many of the findings are consistent with previous studies and support the notion that employers are seeking an ever-increasing number and variety of skill sets from the new hires In addition, we found ongoing evidence of a recruitment gap (Todd, McKeen & Gallupe 1995) where, despite many firms' stated emphasis on well-rounded individuals with business knowledge and strong "soft skills," the job advertising aspect of the recruiting process continues to focus on "hard skills" The changing demand patterns for IT professionals necessitate life-long learning skills not only for IT practitioners but also for the academics who teach them

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

Abstract: Influenza viruses constitute a major health threat and economic burden globally, frequently exacerbated by preexisting or rapidly emerging resistance to antiviral therapeutics. To address the unmet need of improved influenza therapy, we have created EIDD-2801, an isopropylester prodrug of the ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) that has shown broad anti-influenza virus activity in cultured cells and mice. Pharmacokinetic profiling demonstrated that EIDD-2801 was orally bioavailable in ferrets and nonhuman primates. Therapeutic oral dosing of influenza virus–infected ferrets reduced group pandemic 1 and group 2 seasonal influenza A shed virus load by multiple orders of magnitude and alleviated fever, airway epithelium histopathology, and inflammation, whereas postexposure prophylactic dosing was sterilizing. Deep sequencing highlighted lethal viral mutagenesis as the underlying mechanism of activity and revealed a prohibitive barrier to the development of viral resistance. Inhibitory concentrations were low nanomolar against influenza A and B viruses in disease-relevant well-differentiated human air-liquid interface airway epithelia. Correlating antiviral efficacy and cytotoxicity thresholds with pharmacokinetic profiles in human airway epithelium models revealed a therapeutic window >1713 and established dosing parameters required for efficacious human therapy. These data recommend EIDD-2801 as a clinical candidate with high potential for monotherapy of seasonal and pandemic influenza virus infections. Our results inform EIDD-2801 clinical trial design and drug exposure targets.