Georgia State University

About: Georgia State University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13988 authors who have published 35895 publications receiving 1164332 citations. The organization is also known as: GSU & Georgia State.

The Effect of the Environment on Export Performance among Telecommunications New Ventures

Abstract: The importance of exports for achieving business growth and superior financial performance is widely recognized in the literature. Consequently, researchers have sought to identify the variables th...

The impact of click chemistry in medicinal chemistry.

Abstract: Introduction: The copper(I)-catalyzed 1,3-dipolar cycloaddition of alkynes and azides to form 1,2,3-triazoles is the most popular reaction in click chemistry. This reaction is also near-perfect, in terms of its robustness, due to the high degree of reliability and complete specificity. Furthermore, this reaction has been used increasingly in drug discovery, because the formed 1,2,3-triazole can act as both a bioisostere and a linker. Areas covered: This review provides an overview of a most important click reaction, 1,3-dipolar cycloadditions of alkynes and azides, in the drug discovery. Expert opinion: Click chemistry is a very powerful tool, in the drug discovery, because it is very efficient in the creation of compound libraries through combinatorial methodology. However, the 1,2,3-triazole ring itself is not a commonly used pharmacophore and has rarely been found in marketed drugs, demonstrating that there are still some limitations during the use of 1,2,3-triazole in the molecules of drug candidates....

Firm size and productivity differential: theory and evidence from a panel of US firms

Abstract: The US industrial sector displays heterogeneity among firms on the basis of their size: smaller firms exhibit a higher profit rate, lower survival probability and difficulty in accessing the capital market. A simple theoretical model that generates these features based on private information regarding managerial actions at firm-level production is developed and tested. Using a large panel of publicly traded US firms, parameters of the production technology for large and small firms are estimated for the 1970–1989 period. The empirical results indicate that small firms are significantly more productive but also more risky than their large counterparts. The estimation results imply that the notion of a tradeoff between flexibility and efficiency be adjusted for the dimension of risk. Small firms facing market uncertainties, capital constraints and other challenges undertake actions that make them more efficient than large firms but is achieved at the cost of increasing their riskiness.