Georgia State University

About: Georgia State University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13988 authors who have published 35895 publications receiving 1164332 citations. The organization is also known as: GSU & Georgia State.

Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation.

Abstract: Inflammation has classically been defined histopathologically, especially by the presence of immune cell infiltrates. However, more recent studies suggest a role for "low-grade" inflammation in a variety of disorders ranging from metabolic syndrome to cancer, which is defined by modest elevations in pro-inflammatory gene expression. Consequently, there is a need for cost-effective, non-invasive biomarkers that, ideally, would have the sensitivity to detect low-grade inflammation and have a dynamic range broad enough to reflect classic robust intestinal inflammation. Herein, we report that, for assessment of intestinal inflammation, fecal lipocalin 2 (Lcn-2), measured by ELISA, serves this purpose. Specifically, using a well-characterized mouse model of DSS colitis, we observed that fecal Lcn-2 and intestinal expression of pro-inflammatory cytokines (IL-1β, CXCL1, TNFα) are modestly but significantly induced by very low concentrations of DSS (0.25 and 0.5%), and become markedly elevated at higher concentrations of DSS (1.0 and 4.0%). As expected, careful histopathologic analysis noted only modest immune infiltrates at low DSS concentration and robust colitis at higher DSS concentrations. In accordance, increased levels of the neutrophil product myeloperoxidase (MPO) was only detected in mice given 1.0 and 4.0% DSS. In addition, fecal Lcn-2 marks the severity of spontaneous colitis development in IL-10 deficient mice. Unlike histopathology, MPO, and q-RT-PCR, the assay of fecal Lcn-2 requires only a stool sample, permits measurement over time, and can detect inflammation as early as 1 day following DSS administration. Thus, assay of fecal Lcn-2 by ELISA can function as a non-invasive, sensitive, dynamic, stable and cost-effective means to monitor intestinal inflammation in mice.

Black-White Differences in Attitudes toward Homosexuality and Gay Rights

Abstract: Black homophobia has been cited as a contributing factor in slowing mobilization against AIDS in the African-American community, as an obstacle to black lesbians and gay men in coming to terms with their sexuality, and as a challenge to the legitimacy of the gay rights movement. Yet evidence that blacks are more homophobic than whites is quite limited. This article uses responses from almost seven thousand blacks and forty-three thousand whites in 31 surveys conducted since 1973 to give more definitive answers on black-white attitudinal differences and their demographic roots. Despite their greater disapproval of homosexuality, blacks' opinions on sodomy laws, gay civil liberties, and employment discrimination are quite similar to whites' opinions, and African Americans are more likely to support laws prohibiting antigay discrimination. Once religious and educational differences are controlled, blacks remain more disapproving of homosexuality but are moderately more supportive of gay civil liberties and markedly more opposed to antigay employment discrimination than are whites. Yet religion, education, gender, and age all have weaker impacts on black than on white attitudes, suggesting that black and white attitudes have different roots