Institution
Georgia State University
Education•Atlanta, Georgia, United States•
About: Georgia State University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13988 authors who have published 35895 publications receiving 1164332 citations. The organization is also known as: GSU & Georgia State.
Topics: Population, Poison control, Mental health, Stars, Health care
Papers published on a yearly basis
Papers
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TL;DR: Three organizations studied here suggest the answer is "yes," when the unique characteristics of both environments are successfully blended.
Abstract: Three organizations studied here suggest the answer is "yes," when the unique characteristics of both environments are successfully blended.
362 citations
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01 Jan 1980362 citations
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TL;DR: In this article, Tocqueville analyzes des mouvements sociaux apparaissent comme des cas limites ou les chances structurelles (la vulnerabilite de l'Etat a la pression politique populaire) coincide avec les chances percues (le fait que le public soit au courant des possibilites de succes dans le cadre de son activite de protestation).
Abstract: Les analyses de Tocqueville des mouvements sociaux apparaissent comme des cas limites ou les chances structurelles (la vulnerabilite de l'Etat a la pression politique populaire) coincide avec les chances percues (le fait que le public soit au courant des possibilites de succes dans le cadre de son activite de protestation). L'A. estime toutefois que cette coincidence n'apparait pas toujours. Il met en avant une disjonction de ce type en ce qui concerne la revolution iranienne entre 1977 et 1979. Sur certains plans la monarchie n'etait pas, en soi, vulnerable sur le plan structurel. Les iraniens ont percu, en revanche, une possibilite de succes en observant un changement dans la nature du mouvement de protestation
361 citations
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Pennsylvania State University1, Tel Aviv University2, University of Maryland, Baltimore County3, Goddard Space Flight Center4, Georgia State University5, The Catholic University of America6, University of Florida7, Johns Hopkins University8, Space Telescope Science Institute9, Ohio State University10, Universities Space Research Association11, Ohio University12
TL;DR: In this paper, the authors present results from a 900 ks exposure of NGC 3783 with the High-Energy Transmission Grating Spectrometer on board the Chandra X-Ray Observatory.
Abstract: We present results from a 900 ks exposure of NGC 3783 with the High-Energy Transmission Grating Spectrometer on board the Chandra X-Ray Observatory. The resulting X-ray spectrum, which covers the 0.5-10 keV energy range, has the best combination of signal-to-noise ratio and resolution ever obtained for an AGN. This spectrum reveals absorption lines from H-like and He-like ions of N, O, Ne, Mg, Al, Si, and S. There are also possible absorption lines from H-like and He-like Ar and Ca as well as H-like C. We also identify inner-shell absorption from lower ionization ions such as Si VII-Si XII and S XII-S XIV. The iron absorption spectrum is very rich; L-shell lines of Fe XVII-Fe XXIV are detected, as well as probable resonance lines from Fe XXV. A strong complex of M-shell lines from iron ions is also detected in the spectrum. The absorption lines are blueshifted relative to the systemic velocity by a mean velocity of -590 ± 150 km s-1. We resolve many of the absorption lines, and their mean FWHM is 820 ± 280 km s-1. We do not find correlations between the velocity shifts or the FWHMs with the ionization potentials of the ions. Most absorption lines show asymmetry, having more extended blue wings than red wings. In O VII we have resolved this asymmetry to be from an additional absorption system at approximately -1300 km s-1. The two X-ray absorption systems are consistent in velocity shift and FWHM with the ones identified in the UV lines of C IV, N V, and H I. Equivalent width measurements for all absorption and emission lines are given and column densities are calculated for several ions. We resolve the narrow Fe Kα line at 6398.2 ± 3.3 eV to have an FWHM of 1720 ± 360 km s-1, which suggests that this narrow line may be emitted from the outer part of the broad-line region or the inner part of the torus. We also detect a "Compton shoulder" redward of the narrow Fe Kα line, which indicates that it arises in cold, Compton-thick gas.
360 citations
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TL;DR: Considering the favorable pharmacokinetics of UIC-94017 when administered with ritonavir, the present data warrant that UIC -94017 be further developed as a potential therapeutic agent for the treatment of primary and multi-PI-resistant HIV-1 infections.
Abstract: We designed, synthesized, and identified UIC-94017 (TMC114), a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) containing a 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane (bis-THF) and a sulfonamide isostere which is extremely potent against laboratory HIV-1 strains and primary clinical isolates (50% inhibitory concentration [IC(50)], approximately 0.003 micro M; IC(90), approximately 0.009 micro M) with minimal cytotoxicity (50% cytotoxic concentration for CD4(+) MT-2 cells, 74 micro M). UIC-94017 blocked the infectivity and replication of each of HIV-1(NL4-3) variants exposed to and selected for resistance to saquinavir, indinavir, nelfinavir, or ritonavir at concentrations up to 5 micro M (IC(50)s, 0.003 to 0.029 micro M), although it was less active against HIV-1(NL4-3) variants selected for resistance to amprenavir (IC(50), 0.22 micro M). UIC-94017 was also potent against multi-PI-resistant clinical HIV-1 variants isolated from patients who had no response to existing antiviral regimens after having received a variety of antiviral agents. Structural analyses revealed that the close contact of UIC-94017 with the main chains of the protease active-site amino acids (Asp-29 and Asp-30) is important for its potency and wide spectrum of activity against multi-PI-resistant HIV-1 variants. Considering the favorable pharmacokinetics of UIC-94017 when administered with ritonavir, the present data warrant that UIC-94017 be further developed as a potential therapeutic agent for the treatment of primary and multi-PI-resistant HIV-1 infections.
358 citations
Authors
Showing all 14161 results
Name | H-index | Papers | Citations |
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Paul M. Thompson | 183 | 2271 | 146736 |
Michael Tomasello | 155 | 797 | 93361 |
Han Zhang | 130 | 970 | 58863 |
David B. Audretsch | 126 | 671 | 72456 |
Ian O. Ellis | 126 | 1051 | 75435 |
John R. Perfect | 119 | 573 | 52325 |
Vince D. Calhoun | 117 | 1234 | 62205 |
Timothy E. Hewett | 116 | 531 | 49310 |
Kenta Shigaki | 113 | 570 | 42914 |
Eric Courchesne | 107 | 240 | 41200 |
Cynthia M. Bulik | 107 | 714 | 41562 |
Shaker A. Zahra | 104 | 293 | 63532 |
Robin G. Morris | 98 | 519 | 32080 |
Richard H. Myers | 97 | 316 | 54203 |
Walter H. Kaye | 96 | 403 | 30915 |