Institution
Gifu University of Medical Science
Education•Gifu City, Japan•
About: Gifu University of Medical Science is a education organization based out in Gifu City, Japan. It is known for research contribution in the topics: Imaging phantom & Motion sickness. The organization has 89 authors who have published 202 publications receiving 1350 citations.
Topics: Imaging phantom, Motion sickness, Virus, Simulator sickness, Baroreflex
Papers published on a yearly basis
Papers
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TL;DR: Although the prevalence of E. coli-colonized premature infants at birth was low, the rate of antibiotic resistance and the attack rate for EOS were high and Infants with ESBL-E positive mothers should be closely monitored for Eos.
Abstract: BACKGROUND Escherichia coli causes neonatal early-onset sepsis (EOS) that is associated with high mortality and increasing antibiotic resistance. Thus, we estimated the prevalence, antibiotic susceptibility and risk factors for colonization of E. coli in premature infants at birth and characterized the pathogenicity of the isolates. METHODS A prospective surveillance study was conducted at three Japanese perinatal centers between August 2014 and February 2017. Infants weighing <2 kg and/or at gestational age <35 weeks at birth were enrolled. We screened the mothers and neonates for E. coli colonization. Pulsed-field gel electrophoresis was used to analyze the relatedness between the maternal and neonatal isolates. Virulence factors for the isolates were determined using polymerase chain reaction. RESULTS We enrolled 421 premature infants born to 382 mothers. The rate of colonization in mothers was 47.6%, comprising 5.9% extended-spectrum beta-lactamase-producing E. coli (ESBL-E) and 20.0% ampicillin-resistant strains. Ten (2.4%) infants exhibited colonization; ESBL-E and ampicillin-resistant strains colonized three and four infants, respectively. Three antibiotic-resistant, strain-positive infants developed EOS. Pulsed-field gel electrophoresis revealed vertical transmission of bacteria in four infants. Multivariate logistic regression analysis revealed that ESBL-E-positive mothers [odds ratio (OR), 19.2; 95% confidence interval (CI), 2.5-145.7)] and vaginal delivery (OR, 9.4; 95% CI, 1.7-50.7) were risk factors for neonatal colonization. The infant isolates possessed numerous virulence factors. CONCLUSIONS Although the prevalence of E. coli-colonized premature infants at birth was low, the rate of antibiotic resistance and the attack rate for EOS were high. Infants with ESBL-E positive mothers should be closely monitored for EOS.
7 citations
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TL;DR: It is demonstrated that the modified sum-peak method is quite simple and practical and is useful to measure multiple nuclides.
7 citations
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TL;DR: In this study, glutathione-S-transferase pull-down assay and mass spectrometry enabled identification of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel interaction partner for LEF1.
Abstract: Lymphocyte enhancer factor 1 (LEF1), a member of the LEF/T-cell-specific factor (TCF) family of the high mobility group domain transcription factors, acts downstream in canonical Wnt signaling. Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblastic leukemia. LEF1-associated proteins are crucial for regulating its transcriptional activity. In this study, glutathione-S-transferase pull-down assay and mass spectrometry enabled identification of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel interaction partner for LEF1. The interaction between LEF1 and DNA-PKcs was confirmed using in vivo co-immunoprecipitation. Furthermore, double immunofluorescence observations showed that LEF1 and DNA-PKcs colocalized in the nuclei of colon adenocarcinoma cell lines. Identification of the interaction between LEF1 and DNA-PKcs may provide clues for a novel therapy for cancer treatment as well as for understanding LEF1-mediated transcriptional regulation.
7 citations
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TL;DR: A deep learning-based CAD system trained using mammography images from a large number of Japanese women with high quality reading might work well in Asian women who have similar breast density, size, and shape to those ofJapanese women.
7 citations
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TL;DR: The first Cu-catalyzed dehydrogenative C-O cyclization for the synthesis of furan-fused thienoacenes was described in this paper, where the use of a mixed solvent of N-methyl-2-pyrrolidone, ethylene glycol monomethyl ether, and toluene was essential for suppressing side reactions and efficiently promoting the reaction.
7 citations
Authors
Showing all 89 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tadaaki Mano | 36 | 154 | 3955 |
Tetsuro Ito | 32 | 108 | 3196 |
Shinji Kunishima | 28 | 126 | 2640 |
Kunihiko Tanaka | 18 | 95 | 938 |
Hiroki Mandai | 17 | 71 | 871 |
Yoko S. Kaneko | 15 | 42 | 923 |
Takeshi Hatta | 14 | 96 | 888 |
Toshiro Noshita | 13 | 47 | 481 |
Hiroyuki Nagai | 13 | 89 | 592 |
Hiroshi Miyahara | 13 | 66 | 545 |
Akihiko Takasaki | 13 | 23 | 570 |
Hiroki Takada | 13 | 181 | 798 |
Satoko Mitani | 12 | 26 | 655 |
Yoshinobu Kimura | 11 | 20 | 556 |
Tsuyoshi Sugiyama | 11 | 21 | 903 |