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Institution

Gifu University of Medical Science

EducationGifu City, Japan
About: Gifu University of Medical Science is a education organization based out in Gifu City, Japan. It is known for research contribution in the topics: Imaging phantom & Motion sickness. The organization has 89 authors who have published 202 publications receiving 1350 citations.


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Journal ArticleDOI
TL;DR: The results suggested the possibility of applying a quantitative image reading method for torso FDG-PET imaging, and a combination of the SUV and Z-score may provide increased accuracy of the determination methods, such as computer-aided detection and diagnosis.
Abstract: A better understanding of the standardized uptake value (SUV) ranges of fludeoxyglucose positron emission tomography (FDG-PET) is crucial for radiologists. We have developed a statistical image analysis method for FDG-PET imaging of the torso, based on comparisons with normal data. The purpose of this study was to verify the accuracy of the normal model and usefulness of the statistical image analysis method by using typical cancer cases in the liver, lungs, and abdomen. Our study and the data collection (49 normal and 34 abnormal cases, in terms of PET/CT findings) were approved by the institutional review board. Our scheme consisted of the following steps: (1) normal model construction, (2) anatomical standardization of patient images, and (3) Z-score calculation to show the results of the statistical image analysis. To validate the Z-score index, we sampled 3603 and 1270 voxels in normal organs and abnormal regions, respectively, from the liver, lungs, and the abdomen. We then obtained the SUV and Z-score for each region. A receiver operating characteristics (ROC) analysis-based method was performed to evaluate the discrimination performances of the SUV and Z-score. The discrimination performances of the SUV and Z-score for the objective regions of interest (ROIs) were evaluated by the areas under the ROC curves (AUCs). As a result of the ROC analysis and statistical tests, all AUCs were found to be larger than 0.98. When the ROIs in the objective regions were combined, the mean AUCs of the Z-score and SUV were 0.99 and 0.98, respectively, the difference being statistically significant ( $$p < 0.001$$ ). The results suggested the possibility of applying a quantitative image reading method for torso FDG-PET imaging. Furthermore, a combination of the SUV and Z-score may provide increased accuracy of the determination methods, such as computer-aided detection and diagnosis.

3 citations

Journal ArticleDOI
TL;DR: In this article, the phase transition behavior of polythioethers was investigated using differential scanning calorimetry, polarising optical microscopy and X-ray diffraction.
Abstract: Polythioethers consisting of 1,4‐bis(mercaptomethyl)benzene (MB) with α,ω‐dibromo‐n‐alkanes (An, the number of methylene groups, n = 5–8) (MB‐An) and 4,4′‐bis(mercaptomethyl)biphenyl (MBP) with An (MBP‐An), and polythioesters containing MB and MBP with n‐alkanedioyl dichlorides (AMmC, the number of methylene groups, m = 5–8) (MB‐AMmC and MBP‐AMmC) were synthesised and their phase transition behaviour investigated using differential scanning calorimetry, polarising optical microscopy and X‐ray diffraction. The MPB‐An thioether polymers exhibited a nematic phase with good thermal stability but the MB‐An thioether and MB‐AMmC and MBP‐AMmC thioester polymers exhibited no mesophase. The dependence of liquid crystalline behaviour on the chemical structure of the polymers is discussed.

3 citations

Journal ArticleDOI
TL;DR: Evidence is provided that RSV infection suppresses the subsequent development of OVA-induced allergic responses partly by enhancing FasL-mediated apoptosis of pulmonary γδ T cells.
Abstract: Background: It has been reported that adoptive transfer of γδ T cells increases the cellular infiltration, especially eosinophils, in the lungs of allergic mice, suggesting that γδ T cells may play a proinflammatory role in allergic airway inflammation. Respiratory syncytial virus (RSV) infection can decrease the number of Th2-type γδ T cells. However, the underlying mechanisms remain unknown. Methods: BALB/c mice were inoculated intranasally with RSV before or after sensitization to OVA. The amounts of Th1/Th2 cytokines as well as the levels of specific antibodies were determined by ELISA. The apoptotic death of pulmonary γδ T cells was analyzed by flow cytometry. Results: Adoptive transfer of γδ T cells increased the production of Th2 cytokines in the lungs and allergy-related antibodies in the serum, further confirming that γδ T cells act as pro-inflammatory cells or a promoter for the development of allergic asthma. RSV infection before sensitization to OVA enhanced apoptotic death of pulmonar...

3 citations

Journal ArticleDOI
TL;DR: Evidence is provided that the CpG ODN has a prophylactic effect on the JCP-induced Th2-type allergic responses by establishing or restoring a Th1-type shift of immune environments.
Abstract: Background. Over 10% of entire population in Japan suffer from allergic diseases induced by Japanese cedar pollen (JCP) every spring. In terms of preventive medicine, it has become a matter of urgency to establish successful prophylactic and therapeutic strategies for controlling the disorders. The effect of an oligodeoxynucleotide containing a cytidine–guanosine motif (CpG ODN) on the regulation of immune responses induced by JCP was investigated in this study. Methods. BALB/c mice were inoculated with CpG ODN intraperitoneally before intranasal sensitization to JCP. Cellular infiltration in the lung of BALB/c mice after treatment with CpG ODN or JCP was performed by hematoxylin and eosin (H&E) staining. Antibody titers and cytokines levels were determined by ELISA. Results. Intranasal inoculation of BALB/c mice with JCP induced a T-helper type 2 (Th2-type) dominant immune response, as characterized by the production of interleukin (IL)-4 and IL-5 in the lung and of JCP-specific IgE antibody in serum. Pr...

3 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20221
202127
202024
201914
201814
201714