Gifu University of Medical Science

About: Gifu University of Medical Science is a education organization based out in Gifu City, Japan. It is known for research contribution in the topics: Imaging phantom & Motion sickness. The organization has 89 authors who have published 202 publications receiving 1350 citations.

Effect of Difference in Information Between Vision and Vestibular Labyrinth on a Human Body

Abstract: For development of motion sickness or visually induced motion sickness (VIMS) caused by sensory conflict, we can set the hypothesis that positive correcting differences in information among afferent input from each sensoria lead to the suppression of symptoms attributed to sensory conflict In this study, as fundamental verification of above hypothesis, we verified the effect on the human body in case of stimulating only vision, only vestibular-labyrinth system, and vision and vestibular-labyrinth system (in phase and opposite phase), simultaneously For the stimulating to the vestibular-labyrinth system, the method of delivering electrical stimulus called galvanic vestibular stimulation (GVS) from body surface is utilized As a result, 2 conclusions were obtained First was the disruption between subjective and objective evaluation was recognized It was assumed that the task included vision and GVS with opposite phase had other factor of sensory conflict, which was not considered in this study Second was significant changes between each task were not confirmed from HRV and RRIV analysis In addition, there was disruption between the results of subjective and objective evaluation Therefore, further verification is required with changing study conditions and settings such as posture

Exposure Conditions According to Breast Thickness and Glandularity in Japanese Women

Abstract: We retrospectively collected data on patient age, exposure factors, and compressed breast thickness CBT from 7,566 mammograms, which were obtained in the medio-lateral oblique projection over a 1-year period. The mean CBT was 31.7i¾?mm, and was <30i¾?mm in 44.8i¾?% of cases. In 93.1i¾?% of the mammograms with CBT 20-29i¾?mm, tube voltage was 24i¾?kV. In 196 mammograms exposed at 24i¾?kV, the CBT was 29i¾?mm and a maximum mAs value was over than 270 mAs. In order to evaluate the dose reduction, the tube loading was measured, using the semi-automatic AEC mode, for the mammography phantoms with a thickness of 10 to 30i¾?mm while varying the tube voltage from 24 to 27i¾?kV. The tube loading at 27i¾?kV was approximately 50i¾?% lower than that at 24i¾?kV, the average glandular dose calculated could be reduced by about 20i¾?%.

Reconstruction of semiautomated cardiac regions of interest using iodine-123 metaiodobenzylguanidine myocardial scintigraphy.

Abstract: INTRODUCTION Analysis using cardiac iodine-123 metaiodobenzylguanidine (MIBG) scintigraphy with regions of interest (ROIs) is useful for assessing myocardial sympathetic activity. However, manual placement of the cardiac ROI is sometimes difficult because myocardial MIBG uptake is reduced in patients with heart failure. A new method was developed to reconstruct the semiautomated cardiac ROI in a sympathetic denervated heart. MATERIALS AND METHODS Using dynamic planar data, a summed image was generated and the matrix size was changed. Then, the radial count profiles originating from the center of the left ventricle were generated to extract the myocardial count profiles. An asymmetric Gaussian distribution was fitted to each profile and the epicardial border was defined by the threshold method. This program was tested in 50 patients, and its reproducibility was validated when compared with the manual tracing method. RESULTS The semiautomated method yielded a better quality image compared with the standard image with higher counts. Cardiac ROIs were generated successfully in each patient within normal limits. The intraobserver and interobserver agreements were excellent (P<0.0001 each). This approach showed a significantly higher consistency in measuring the heart-to-mediastinum ratio as compared with the manual tracing method (P<0.05). CONCLUSION The semiautomated method is useful in generating cardiac ROIs with high reproducibility in myocardial MIBG imaging.

ETV6-related thrombocytopenia associated with a transient decrease in von Willebrand factor.

Abstract: ETV6-related thrombocytopenia is an autosomal dominant thrombocytopenia, characterized by a bleeding tendency and predisposition to hematological malignancies. The similarity in symptoms makes differentiating immune and congenital thrombocytopenia challenging. We report a 5-year-old girl who presented with chronic thrombocytopenia associated with repetitive and long-lasting epistaxis, leading to blood transfusion for severe anemia. Blood tests showed thrombocytopenia (52 × 103/µL) with normal-sized platelets and transiently low von Willebrand factor (VWF) levels (VWF:RCo 13%, VWF:Ag 50%); therefore, von Willebrand disease type 2 was initially suspected. Repetition of the blood tests revealed normal levels of VWF. Exome and Sanger sequencing identified a germline ETV6 heterozygous variant, c.641C > T:p.(P214L). No additional pathogenic variants were found, including VWF, in the gene panel testing of the 53 known target causative genes for thrombocytopenia. High-throughput exome sequencing for chronic thrombocytopenia can be utilized to differentially diagnose ETV6-related thrombocytopenia from chronic/intractable immune thrombocytopenia and to effectively monitor malignancy.