Government College

About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.

In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping

Abstract: Graphene-based materials have attracted considerable interest owing to their distinctive characteristics, such as their biocompatibility in terms of both their physical and intrinsic chemical properties. The use of nanomaterials with graphene as a biocompatible agent has increased due to an uptick in dedication from biomedical investigators. Here, GO-ZnO was characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), ultraviolet-visible (UV-Vis) spectroscopy, energy dispersive X-ray analysis (EDAX), and Raman spectroscopy for structural, morphological, and elemental analysis. The toxic extent of GO-ZnO was noted by a methyl-thiazole-tetrazolium (MTT), while cellular morphology was observed towards the MCF-7 cells using an inverted microscope at magnification 40×. The cytotoxic effect of GO-ZnO investigated the cell viability reduction in a dose-dependent manner, as well as prompted the cell demise/destruction in an apoptotic way. Moreover, statistical analysis was performed on the experimental outcomes, with p-values < 0.05 kept as significant to elucidate the results. The generation of reactive oxygen species (ROS) demonstrated the potential applicability of graphene in tumor treatment. These key results attest to the efficacy of GO-ZnO nanocomposites as a substantial candidate for breast malignancy treatment.

Experimental study on cold-formed steel web stiffened lipped channel columns undergoing distortional–global interaction

Abstract: This paper describes the design and testing of cold-formed steel web stiffened lipped channel sections experiencing distortional–global buckling mode interaction under axial compression. The relevant literature was reviewed, sections were selected with nearly coincident distortional and global buckling loads to have strong interaction effects. Selected sections satisfy the geometric limitations for pre qualified sections in order to apply direct strength method (DSM) in Appendix 1 of the North American Specifications (AISI-S100:2007). A total of 15 web stiffened lipped channel compression members were tested under pin with warping restrained end condition. The experimental results were compared with the current design rules in AISI-DSM and the quality of DSM based design procedures based on distortional–global mode interaction was reviewed. In addition, a reliability analysis was performed to assess the quality of current DSM and D–G interaction design procedure to predict the ultimate capacity of the sections.

S-Functionalized Mo2C Monolayer as a Novel Electrode Material in Li-Ion Batteries

Abstract: First-principles calculations have been performed to calculate the electrochemical properties of the S-functionalized Mo2C (Mo2CS2) monolayer using the projected-augmented wave (PAW) method based on density functional theory (DFT). The geometrical optimization reveals that the Li gets favorably adsorbed on the top of the Mo layer. The metallic nature of S-functionalized Mo2C maintains its electronic conduction with and without Li adsorption, which reflects its special role in Li-ion battery technologies. Functionalization of S-atoms significantly increases the Li-adsorption energy in the resultant monolayer which consequently alters the charge storage capacity of Li-ion batteries (LIBs). The calculated low diffusion barrier (∼0.22 eV) of adsorbed Li ion implies the high mobility and cyclic ability of Mo2CS2 monolayer. Moreover, the calculated theoretical specific capacity, 410 mA h g–1, and average voltage, 0.3 V, suggest its application as a proficient anode material in LIBs.

Overview on Nitrogen containing compounds and their assessment based on ‘International Regulatory Standards’

Abstract: Heterocyclic compounds have a role in most fields of sciences such as medicinal chemistry, biochemistry also another area of sciences. More than 90% of new drugscontain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. Compounds derived from heterocyclic rings in pharmacy, medicine, agriculture, plastic, polymer and other fields.Most active heterocycles that have shown considerable biological actions as antifungal, anti-inflammatory, antibacterial, anticonvulsant, antiallergic, herbicidal, anticancer activity. There is always a strong need for new and efficient processes in synthesizing of new Heterocycles.Alum have been used as a novel catalyst in the synthesis of Schiff’s bases. Synthesized Schiff’s bases are free from use of ICH class 1 and Class 2 solvents and also free from structural alerts genotoxic impurities. This review highlights on various aspects of heterocyclic compounds with its biological activity & regulatory assessment based on the ‘International Regulatory Standards’. Keywords: Heterocycles. Nitrogen containing compounds Biological activity, History, Regulatory assessment, International Regulatory Standards