Institution
Government College
About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.
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TL;DR: The physicochemical properties of spray-dried micro-complexes of cefuroxime axetil (CFA) with HPβCD in presence and/or absence of ternary components polyvinylpyrrolidone K30 (PVP K30), hydroxypropylmethylcellulose (HPMC), poloxamer 188 and polyethylene glycol 4000 (PEG 4000) along with Aerosil®200 as an adsorbent were investigated as discussed by the authors.
Abstract: The physicochemical properties of spray dried micro-complexes of cefuroxime axetil (CFA) with hydroxypropyl-β-cyclodextrin (HPβCD) in presence and/or absence of ternary components polyvinylpyrrolidone K30 (PVP K30), hydroxypropylmethylcellulose (HPMC), poloxamer 188 and/or polyethylene glycol 4000 (PEG 4000) along with Aerosil®200 as an adsorbent were investigated. The phase solubility studies revealed AL type of solubility curve in binary as well as ternary systems. The stability constant 382.70 ± 2.4 M−1 of binary system i.e. CFA with HPβCD was significantly improved to 427.84 ± 3.8, 447.09 ± 4.3, 488.28 ± 4.6 and 502.21 ± 5.1 M−1 in presence of PVP K30, HPMC, poloxamer 188 and PEG 4000 respectively indicating positive effect of their addition. The micro-complexes of CFA were characterized by Fourier transformation infrared spectroscopy, X-ray powder diffractometry, differential scanning calorimetry, scanning electron microscopy, particle size analysis, and dissolution. In all characterization studies, ternary systems performed better in comparison to binary systems as a result of synergistic effect of ternary complexation as well as particle size reduction achieved by a spray drying technology.
22 citations
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TL;DR: A novel d -mannose-mediated targeted drug delivery system (GO–CH–Ma) for targeting glioblastoma cancer was developed by loading Ulvan lactua as the anticancer model drug onto functionalized graphene oxide.
22 citations
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TL;DR: As the dominant classes of analgesic drugs such as the NSAIDs and the opiates are limited by their side effects and tolerability, elucidation of the molecular mechanisms responsible for inflammatory pain provides novel opportunities for therapeutic approaches for managing inflammatory pain, with improved specificity, efficacy, and possibly with fewer toxic effects.
Abstract: There is a large unmet medical need in the area of treatment of inflammatory pain initiated by tissue damage or inflammation that manifests as spontaneous pain and pain hypersensitivity (hyperalgesia).The current review focuses on the key mechanisms that produce hyperalgesia that accompanies inflammation. Also, the inflammatory mediators that interact with neurons to produce hyperalgesia are explored. As the dominant classes of analgesic drugs such as the NSAIDs and the opiates are limited by their side effects and tolerability, elucidation of the molecular mechanisms responsible for inflammatory pain provides novel opportunities for therapeutic approaches for managing inflammatory pain, with improved specificity, efficacy, and possibly with fewer toxic effects.
22 citations
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TL;DR: Among all binary systems studied, the 1:3 proportion of ezetimibe: Pluronic 188 showed fastest dissolution rate (DE90: 73.38% +/- 3.95) suggesting optimum ratio of the surfactant used.
Abstract: Solid dispersions of the poorly water-soluble drug ezetimibe were prepared with a surfactant, Pluronic® 188 in different ratios and characterized by FTIR, XRD, DSC and dissolution studies The melting method was employed to prepare the solid dispersions whereas a physical mixture (1:3) was prepared by co-grinding the individual components in a mortar Physical studies demonstrated a significant reduction in crystallinity with a possibility of presence of amorphous character of drug in the solid dispersions of ezetimibe Among all binary systems studied, the 1:3 proportion of ezetimibe: Pluronic® 188 showed fastest dissolution rate (DE 90 : 7338% ± 395) suggesting optimum ratio of the surfactant used
22 citations
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TL;DR: Assessment of total oxidation status (TOS), related parameters and their relationship to DNA damage (%) and homocysteine level in normal pregnant women in low-income participants found changes in pregnant women were considered normal for pregnant women having optimum blood pressure and normal child birth.
Abstract: Maternal oxidative stress during pregnancy may impair fetal growth and help in the development of diseases in adulthood. The aim of current study was to assess total oxidation status (TOS), related parameters and their relationship to DNA damage (%) and homocysteine level in normal pregnant women in low-income participants. In a cross-sectional study healthy women were grouped as normal, while age matched nulliparous and singleton pregnancies were included for first, second and third trimester groups. TOS (P < 0.01), melanodialdehyde (MDA) (P < 0.001), aspartate aminotransferase (AST) (P < 0.01), triiodothyronine (T3) (P < 0.01), thyroxine (T4) (P < 0.01), and homocysteine (P < 0.001), in pregnant women were significantly higher as compared to normal healthy women. While serum total proteins (P < 0.01), albumin (P < 0.01) and total antioxidant status (TAS) (P < 0.001) decreased significantly as compared to normal healthy women. Women in third trimester showed a significantly high level of body temperature (P < 0.01), triglyceride (P < 0.01), LDL-cholesterol (P < 0.05), AST (P < 0.01), T3 (P < 0.01), homocysteine (P < 0.001), TOS (P < 0.01) and MDA (P < 0.001) but a lower concentration of serum proteins, albumin and TAS at the end of the pregnancy. Pearson correlation indicated a positive relationship of homocysteine with triglycerides (P < 0.027), TOS (P < 0.01), MDA (P < 0.035) and had a negative relationship with total protein (P < 0.026). DNA damage was strongly related with T3 (P < 0.008), TOS (P < 0.02), MDA (P < 0.037) and MBI (P < 0.048) profiles of pregnant women. These changes were considered normal for pregnant women having optimum blood pressure and normal child birth. Hormonal influences and hemodilution may contribute towards the observed changes in this study.
22 citations
Authors
Showing all 4481 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rajesh Kumar | 149 | 4439 | 140830 |
Sanjeev Kumar | 113 | 1325 | 54386 |
Rakesh Kumar | 91 | 1959 | 39017 |
Praveen Kumar | 88 | 1339 | 35718 |
V. Balasubramanian | 54 | 457 | 10951 |
Ghulam Murtaza | 53 | 1005 | 14516 |
Marimuthu Govindarajan | 52 | 212 | 6738 |
Muhammad Akram | 43 | 393 | 7329 |
Ghulam Abbas | 40 | 439 | 6396 |
Shivaji H. Pawar | 39 | 168 | 4754 |
Muhammad Afzal | 38 | 118 | 4318 |
Deepankar Choudhury | 35 | 199 | 3543 |
Hidayat Hussain | 34 | 316 | 5185 |
Hitesh Panchal | 34 | 152 | 3161 |
Sher Singh Meena | 33 | 187 | 3547 |