Government College

About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.

Structural and Theoretical Investigations, Hirshfeld Surface Analyses, and Cytotoxicity of a Naphthalene-Based Chiral Compound.

Abstract: A novel Schiff base compound derived from the condensation of 2-hydroxy-1-naphthaldehyde with (1S,2S)-(-)-1,2-diphenylethylenediamine in 2:1 M ratio was reported and investigated by elemental analyses, Fourier transform infrared and NMR spectroscopic studies, and single-crystal X-ray crystallography. Hirshfeld surface analyses were also carried out to measure the various intermolecular contacts controlling the supramolecular topology, suggesting the H···O (7.6%) contacts to be the most significant interactions, whereas the H···H (48.9%) and C···H (40.2%) interactions are less-significant. The data obtained from the energy calculations revealed the structure observed experimentally to be the most stable isomer and its energy being lower by 18.0441 kcal/mol than the less stable one. Density functional theory calculations were also carried out to analyze the natural charges, reactivity descriptors, and different intramolecular charge transfer interactions. The in vitro anticancer activity of the compound was evaluated by MTT assays against human colorectal cancer cells, HT-29 and SW620. The results showed that the compound has potential anticancer activity against these cells lines.

PCR and microscopic identification of isolated Leishmania tropica from clinical samples of cutaneous leishmaniasis in human population of Kohat region in Khyber Pakhtunkhwa.

Abstract: Leishmania tropica was isolated from the clinical patients of cutaneous leishmaniasis in rural community of Kohat district in Khyber Pakhtunkhwa province and was identified through PCR, microscopy, and culture techniques. A total of 113 samples from the clinical patients were examined through PCR, microscopy, and culture which showed 87.61% (99/113), 53.98% (61/113), and 46.90% (53/113) prevalence. During the study, 186 bp Leishmania tropica was identified through PCR. Thus the sensitivity of PCR is very high as compared to the conventional techniques.

Nationwide survey on barriers for dental research in India.

Abstract: Objective: Research in the dental field is progressing at mightier speed worldwide, but an unfortunately representation of India at this platform is negligible. The present study was undertaken to unearth the barriers for dental research among dental professionals in Indian scenario. Materials and Methods: A cross-sectional questionnaire study was conducted on 1514 participant's (Master of Dental Surgery and Bachelor of Dental Surgery staff) and postgraduates in 40 dental colleges of India selected by multistage random sampling. The response rate was 75.7%. The survey was undertaken from July 2013 to December 2013. The survey instrument was 24-item, investigator developed, self-structured, close-ended, and self-administered questionnaire grouped into four categories that are, institutional/departmental support related barriers, financial/training support related barriers, time-related barriers, and general barriers. Results: Among all respondents 47.23% informed that they are administrative and educational work rather than research work as (P < 0.001). Overall 57.53% of study participants reported lack of administrative and technical support for research work as (P < 0.001). Overall 64.9% reported meager college funding was the barrier (P < 0.001). Overall 61.5% respondents reported lack of time to do research work due to clinical and teaching responsibilities (P < 0.001) was the barrier for research. Largely 80.25% agreed that, the lack of documentation and record maintenance are an obvious barrier for research (P < 0.001). Conclusions: Present study unearths certain barriers for research in an Indian scenario, which includes administrative overburden, lack of funds, and lack of documentation of the dental data. Governing authorities of dentistry in India have to make major interventions to make research non-intensive environment to research-friendly environment.

Enhancing the performance of electrochemical machining of 20MnCr5 alloy steel and optimization of process parameters by PSO-DF optimizer

Abstract: Electrochemical machining (ECM) of metals, particularly steels, plays an important role in numerous industrial applications. The alloy steels especially 20MnCr5 are used as good wear resistant in the applications of boxes, piston bolts, spindles, camshafts, gears, shafts and other mechanical controlling parts. Machining of above complicated shapes with conventional machine tools is cumbersome task. Hence, investigation was made to study the electrochemical machining characteristics of 20MnCr5 alloy steel. Hydrogen peroxide (H2O2) mixed aqueous NaCl was used as electrolyte in order to enhance the machining performance of ECM. The predominant ECM process parameters such as applied voltage (V), inter-electrode gap (IEG) and electrolyte concentration (EC) were considered to study its influence on the material removal rate (MRR) and surface roughness (R a). Microstructure of surface of the 20MnCr5 steel specimen machined with ECM was studied to understand the effect of electrolyte during the machining. The contour plots were generated to study the effect of process parameters as well as their interactions. The optimized machined conditions found with particle swarm optimization (PSO)-desirability function (DF) optimizer were quite close with experimental results. Additional advantage of H2O2 presence was noted that scales formed on flow path of electrolyte were completely removed.