Institution
Government College
About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.
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TL;DR: In this paper, the authors reported green synthesis of C-Dots using guava leaf extract by a cost effective hydrothermal method with water and ethanol as solvents, which showed green emission and good stability to be used for various sensing and energy conversion applications.
19 citations
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TL;DR: In this article, it was shown that under varying conditions one group of the neurosecretory cells of the pars intercerebralis of the brain, the so called A-cells, show histological differences.
Abstract: The present paper gives an account of some experiments upon the insect Iphita limbata
Stal. (Hemiptera: Pyrrhocoridae). The experiments were carried out in order to find out whether in the adult animal there is a relationship between the activity of the neurosecretory cells and the water balance. Under varying conditions one group of the neurosecretory cells of the pars intercerebralis of the brain, the so called “A-cells”, show histological differences. It has been seen that under conditions stimulating hydration there is a marked retention of the stainable colloids in the cytoplasm of “A cells”. This retention probably indicates a relationship between the secretions of “A cells” and the water balance of the insect.
19 citations
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TL;DR: B. acuminata-synthesized AgNPs have a promising potential in antimicrobial food packaging, as well as a foliar spray to control plant pathogens in the field, and to synergize the efficacy of fungicidal and larvicidal formulations.
19 citations
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TL;DR: The present study provides constructive results for colon targeting of 5-FU pellets with industrially feasible processes.
Abstract: Pellets, reliant on pH-sensitivity and time-dependency for drug delivery, provide one of the most versatile opportunities for targeting colon. 5-Fluorouracil (5-FU) loaded pellets were prepared by extrusion-spheronization using Avicel(®) PH101 as a spheronization aid and hydroxypropylmethylcellulose K4M (HPMC K4M) solution as a binder. A 3(2) full factorial design was employed to optimize spheronization speed and time. Obtained pellets were evaluated for flow properties, pellet size, roundness and aspect ratio. Optimized batch was coated in a bottom-spray fluidized bed processor (FBP) with an inner coat of sustained release polymer Eudragit NE30D and an outer coat of pH-sensitive polymer Eudragit FS30D. The coating levels were statistically optimized and in vitro drug release was monitored by changing pH media method. Optimized system with 15% inner and outer coating levels revealed t(50%) (time required for 50% drug release) to be about 9 h while almost complete drug was released in 24 h (98.71 ± 1.33%) with highest dissolution efficiency (DE(24h)) of 58.71%. The optimization model was validated; the predicted and experimental/actual values for validation batch (M1) were in close tolerance and the standard error (SE) was also small. Drug release was also studied at pH 7.4. Scanning electron microscopy (SEM) demonstrated average coating thickness to be 32.50 ± 3.0 µm. Hence, the present study provides constructive results for colon targeting of 5-FU pellets with industrially feasible processes.
19 citations
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TL;DR: Results indicated that MDM2 level is positively correlated with MMP activity and MMP9 secretion, offering strong supporting evidence thatMDM2 can impact growth and metastatic potential of cancer cells through tilting the balance towards pro-angiogenic mechanisms.
Abstract: The Murine Double Minute 2 (MDM2) amplification or overexpression has been found in many tumors with high metastatic and angiogenic ability. Our experiments were designed to explore the impact of MDM2 overexpression, specifically on the levels of angiogenesis-related genes, which can also play a major role in tumor propagation and increase its metastatic potential. In the present study, we have used the human angiogenesis RT² profiler PCR array to compare the gene expression profile between LNCaP and LNCaP-MST (MDM2 transfected) prostate cancer cells, along with LNCaP-MST cells treated with Nutlin-3, an MDM2 specific inhibitor. As a result of the overexpression of MDM2 gene in LNCaP-MST (10.3-fold), Thrombospondin 1 (THBS1), Tumor necrosis factor alpha (TNF-α) and Matrix metallopeptidase 9 (MMP9) were also found to be significantly up-regulated while genes such as Epiregulin (EREG), Tissue inhibitor of metalloproteinases 1 (TIMP1) were down-regulated. Also, we determined the total MMP activity and MMP9 expression in LNCaP, LNCaP-MST and SJSA-1 cells. Our results indicated that MDM2 level is positively correlated with MMP activity and MMP9 secretion. Our findings offer strong supporting evidence that MDM2 can impact growth and metastatic potential of cancer cells through tilting the balance towards pro-angiogenic mechanisms.
19 citations
Authors
Showing all 4481 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rajesh Kumar | 149 | 4439 | 140830 |
Sanjeev Kumar | 113 | 1325 | 54386 |
Rakesh Kumar | 91 | 1959 | 39017 |
Praveen Kumar | 88 | 1339 | 35718 |
V. Balasubramanian | 54 | 457 | 10951 |
Ghulam Murtaza | 53 | 1005 | 14516 |
Marimuthu Govindarajan | 52 | 212 | 6738 |
Muhammad Akram | 43 | 393 | 7329 |
Ghulam Abbas | 40 | 439 | 6396 |
Shivaji H. Pawar | 39 | 168 | 4754 |
Muhammad Afzal | 38 | 118 | 4318 |
Deepankar Choudhury | 35 | 199 | 3543 |
Hidayat Hussain | 34 | 316 | 5185 |
Hitesh Panchal | 34 | 152 | 3161 |
Sher Singh Meena | 33 | 187 | 3547 |