Government College

About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.

Enhanced solubility and dissolution rate of lamotrigine by inclusion complexation and solid dispersion technique.

Abstract: The solid-state properties and dissolution behaviour of lamotrigine in its inclusion complex with beta-cyclodextrin (betaCD) and solid dispersions with polyvinylpyrrolidone K30 (PVP K30) and polyethyleneglycol 6000 were investigated. The phase solubility profile of lamotrigine with betaCD was classified as AL-type, indicating formation of a 1:1 stoichiometry inclusion complex, with a stability constant of 369.96+/-2.26 M(-1). Solvent evaporation and kneading methods were used to prepare solid dispersions and inclusion complexes, respectively. The interaction of lamotrigine with these hydrophilic carriers was evaluated by powder X-ray diffractometry, Fourier transform infrared spectroscopy and differential scanning calorimetry. These studies revealed that the drug was no longer present in crystalline state but was converted to an amorphous form. Among the binary systems tested, PVP K30 (1:5) showed greatest enhancement of the solubility and dissolution of lamotrigine.

Study of effective atomic number and electron density for tissues from human organs in the energy range of 1 keV-100 GeV.

Abstract: Effective atomic numbers' (Z(eff)) effective electron density (N(el)) for human organs and tissues have been computed in the energy region of 1 keV to 100 GeV using WinXCOM. The computed data of Z(eff) and N(el) are tabulated. The computed values are compared with previous results. The computed data of Z(eff)and N(el)for almost all tissues (34 tissues of different human organs) in the given energy range are not available in literature and find application in radiotherapy and dosimetry.