Government College

About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.

Reflection of plane waves at the free surface of a monoclinic thermoelastic solid half-space

Abstract: Lord–Shulman and Green–Lindsay theories of generalized thermoelasticity are applied to study the reflection from a thermally insulated stress-free thermoelastic solid half-space of monoclinic type. A particular model is chosen for the numerical computations of reflection coefficients. Effects of anisotropy and relaxation times are observed on reflection coefficients.

Investigation on the behaviour and strength of cold-formed steel web stiffened built-up battened columns

Abstract: Cold-formed steel built-up sections are commonly used as compression elements to carry larger loads and over longer spans when a single individual section is insufficient. This paper reports a numerical study of the cold-formed steel built-up web stiffened lipped channel sections under axial compression. The built-up sections are formed by two identical lipped channels placed back to back with batten plates and are connected by self-driving screw. The Finite element model is developed by ABAQUS software and the model is validated with the results available in the literature. Three types of web stiffened lipped channel cross section have been chosen for the study, based on the AISI-S100:2007 Geometric limitations. The parametric study is extended by the validated model for various slenderness ratios. The column strength predicted by the finite element analysis is compared with the design column strengths predicted by direct strength method (DSM). Based on this study a recommendation is proposed to DSM.

The metalloprotease, NN-PF3 from Naja naja venom inhibits platelet aggregation primarily by affecting α2β1 integrin.

Abstract: NN-PF3 is a non-toxic, anticoagulant, high-molecular-mass (67.81 kDa) metalloprotease from Indian cobra (Naja naja) venom. In the present study, NN-PF3 was investigated for the mechanism of inhibition of collagen-induced aggregation of human platelets. The complete inhibition of collagen-induced aggregation and partial inhibition of ADP- and epinephrine-induced aggregation has the respective IC50 of 75 ± 5, 185 ± 10, and 232 ± 12 nM, whereas no inhibition of thrombin-, arachidonic acid-, and ristocetin-induced aggregation of platelets was observed in platelet-rich plasma. Further, native NN-PF3 and EDTA-inactivated NN-PF3 inhibited collagen-induced aggregation of washed platelets with respective IC50 of 75 ± 4 and 180 ± 6 nM. The higher inhibitory effect of native NN-PF3 compared with EDTA-inactivated NN-PF3 suggests the enzymatic and non-enzymatic mechanism of inhibition. NN-PF3 pretreatment affected the collagen binding but not the fibrinogen, and fibronectin binding of washed platelets in adhesion assay suggested that the collagen receptors are affected. Western blot study using anti-integrin α2β1 mAb 6F1 suggested that NN-PF3 binds to integrin α2β1 in a primary structure-dependent manner only and is not cleaved. There was a drastic reduction in the intensity of several intracellular signaling phosphotyrosine protein bands when monoclonal anti-phosphotyrosine antibody was used, suggesting that the major activation pathway of platelets get affected, which occurs through glycoprotein VI. NN-PF3 did not bind to collagen as revealed by Western blot using anti-collagen mAb. Furthermore, neither the proteolytic cleavage of fibrinogen nor its degradation products by NN-PF3 contributed for the collagen-induced platelet aggregation inhibition.