Institution
Great Ormond Street Hospital
Healthcare•London, United Kingdom•
About: Great Ormond Street Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Transplantation & Population. The organization has 6535 authors who have published 11240 publications receiving 413647 citations. The organization is also known as: GOSH & Hospital for Sick Children.
Topics: Transplantation, Population, Intensive care, Epilepsy, Hematopoietic stem cell transplantation
Papers published on a yearly basis
Papers
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
11,809 citations
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
7,021 citations
TL;DR: State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology.
4,604 citations
TL;DR: HLH‐2004 chemo‐immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids, and subsequent hematopoietic stem cell transplantation is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease.
Abstract: In HLH-94, the first prospective international treatment study for hemophagocytic lymphohistiocytosis (HLH), diagnosis was based on five criteria (fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hemophagocytosis). In HLH-2004 three additional criteria are introduced; low/absent NK-cell-activity, hyperferritinemia, and high-soluble interleukin-2-receptor levels. Altogether five of these eight criteria must be fulfilled, unless family history or molecular diagnosis is consistent with HLH. HLH-2004 chemo-immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids. Subsequent hematopoietic stem cell transplantation (HSCT) is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease. In order to hopefully further improve diagnosis, therapy and biological understanding, participation in HLH studies is encouraged.
3,848 citations
TL;DR: Use of CT scans in children to deliver cumulative doses of about 50 mGy might almost triple the risk of leukaemia and doses ofabout 60 m Gy might triple therisk of brain cancer.
3,044 citations
Authors
Showing all 6567 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John Hardy | 177 | 1178 | 171694 |
| Robin M. Murray | 171 | 1539 | 116362 |
| Jane Wardle | 144 | 799 | 75276 |
| Martin McKee | 138 | 1732 | 125972 |
| Andrew Steptoe | 137 | 1003 | 73431 |
| Tim J Cole | 136 | 827 | 92998 |
| Alan Ashworth | 134 | 578 | 72089 |
| Paul Harrison | 133 | 1400 | 80539 |
| Peter J. Goadsby | 123 | 946 | 73783 |
| Peter J. Anderson | 120 | 966 | 63635 |
| John E. Deanfield | 120 | 497 | 61067 |
| David A. Isenberg | 119 | 1180 | 68426 |
| Richard J.H. Smith | 118 | 1308 | 61779 |
| Francesco Muntoni | 115 | 963 | 52629 |
| Mike Clarke | 113 | 1037 | 164328 |