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Institution

Griffith University

EducationBrisbane, Queensland, Australia
About: Griffith University is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 13830 authors who have published 49318 publications receiving 1420865 citations.


Papers
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Journal ArticleDOI
TL;DR: A wrapper-feature selection algorithm is proposed based on the Binary Dragonfly Algorithm based on time-varying S-shaped and V-shaped transfer functions to leverage the impact of the step vector on balancing exploration and exploitation.
Abstract: The Dragonfly Algorithm (DA) is a recently proposed heuristic search algorithm that was shown to have excellent performance for numerous optimization problems. In this paper, a wrapper-feature selection algorithm is proposed based on the Binary Dragonfly Algorithm (BDA). The key component of the BDA is the transfer function that maps a continuous search space to a discrete search space. In this study, eight transfer functions, categorized into two families (S-shaped and V-shaped functions) are integrated into the BDA and evaluated using eighteen benchmark datasets obtained from the UCI data repository. The main contribution of this paper is the proposal of time-varying S-shaped and V-shaped transfer functions to leverage the impact of the step vector on balancing exploration and exploitation. During the early stages of the optimization process, the probability of changing the position of an element is high, which facilitates the exploration of new solutions starting from the initial population. On the other hand, the probability of changing the position of an element becomes lower towards the end of the optimization process. This behavior is obtained by considering the current iteration number as a parameter of transfer functions. The performance of the proposed approaches is compared with that of other state-of-art approaches including the DA, binary grey wolf optimizer (bGWO), binary gravitational search algorithm (BGSA), binary bat algorithm (BBA), particle swarm optimization (PSO), and genetic algorithm in terms of classification accuracy, sensitivity, specificity, area under the curve, and number of selected attributes. Results show that the time-varying S-shaped BDA approach outperforms compared approaches.

304 citations

Journal ArticleDOI
TL;DR: In this paper, drug repurposing or repositioning is discussed with a focus on major human parasitic protozoan diseases such as malaria, trypanosomiasis, toxoplasmosis, cryptosporidiosis and leishmaniasis.
Abstract: Parasitic diseases have an enormous health, social and economic impact and are a particular problem in tropical regions of the world. Diseases caused by protozoa and helminths, such as malaria and schistosomiasis, are the cause of most parasite related morbidity and mortality, with an estimated 1.1 million combined deaths annually. The global burden of these diseases is exacerbated by the lack of licensed vaccines, making safe and effective drugs vital to their prevention and treatment. Unfortunately, where drugs are available, their usefulness is being increasingly threatened by parasite drug resistance. The need for new drugs drives antiparasitic drug discovery research globally and requires a range of innovative strategies to ensure a sustainable pipeline of lead compounds. In this review we discuss one of these approaches, drug repurposing or repositioning, with a focus on major human parasitic protozoan diseases such as malaria, trypanosomiasis, toxoplasmosis, cryptosporidiosis and leishmaniasis.

304 citations

Journal ArticleDOI
TL;DR: The antiinflammatory effect of macrolide antibiotics has been well‐established, as has their role in the treatment of certain disorders of chronic airway inflammation, but this effect has not been tested in a randomized, placebo‐controlled study.
Abstract: Objectives: The antiinflammatory effect of macrolide antibiotics has been well-established, as has their role in the treatment of certain disorders of chronic airway inflammation. Several studies have suggested that long-term, low-dose macrolides may be efficacious in the treatment of chronic rhinosinusitis; however, these studies have lacked a control group. To date, this effect has not been tested in a randomized, placebo-controlled study. Method: The authors conducted a double-blind, randomized, placebo-controlled clinical trial on 64 patients with chronic rhinosinusitis. Subjects received either 150 mg roxithromycin daily for 3 months or placebo. Outcome measures included the Sinonasal Outcome Test-20 (SNOT-20), measurements of peak nasal inspiratory flow, saccharine transit time, olfactory function, nasal endoscopic scoring, and nasal lavage assays for interleukin-8, fucose, and a2-macroglobulin. Results. There were statistically significant improvements in SNOT-20 score, nasal endoscopy, saccharine transit time, and IL-8 levels in lavage fluid (P < .05) in the macrolide group. A correlation was noted between improved outcome measures and low IgE levels. No significant improvements were noted for olfactory function, peak nasal inspiratory flow, or lavage levels for fucose and a2-macroglobulin. No improvement in any outcome was noted in the placebo-treated patients. Conclusion: These findings suggest that macrolides may have a beneficial role in the treatment of chronic rhinosinusitis, particularly in patients with low levels of IgE, and supports the in vitro evidence of their antiinflammatory activity. Additional studies are required to assess their place in clinical practice.

304 citations

Journal ArticleDOI
Rafael Lozano1, Nancy Fullman1, John Everett Mumford1, Megan Knight1  +902 moreInstitutions (380)
TL;DR: To assess current trajectories towards the GPW13 UHC billion target—1 billion more people benefiting from UHC by 2023—the authors estimated additional population equivalents with UHC effective coverage from 2018 to 2023, and quantified frontiers of U HC effective coverage performance on the basis of pooled health spending per capita.

304 citations

Journal ArticleDOI
TL;DR: The study concludes that bacterial cell destruction and water disinfection can be achieved using this newly fabricated VLD hybrid photocatalyst.

303 citations


Authors

Showing all 14162 results

NameH-indexPapersCitations
Rasmus Nielsen13555684898
Claudiu T. Supuran134197386850
Jeffrey D. Sachs13069286589
David Smith1292184100917
Michael R. Green12653757447
John J. McGrath120791124804
E. K. U. Gross119115475970
David M. Evans11663274420
Mike Clarke1131037164328
Wayne Hall111126075606
Patrick J. McGrath10768151940
Peter K. Smith10785549174
Erko Stackebrandt10663368201
Phyllis Butow10273137752
John Quackenbush9942767029
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023162
2022572
20214,085
20203,879
20193,573
20183,318