Institution
Griffith University
Education•Brisbane, Queensland, Australia•
About: Griffith University is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 13830 authors who have published 49318 publications receiving 1420865 citations.
Topics: Population, Context (language use), Poison control, Health care, Tourism
Papers published on a yearly basis
Papers
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TL;DR: The authors conducted a systematic review and meta-analysis to synthesize the published and unpublished empirical evidence on the impact of police-led interventions that use procedurally just dialogue focused on improving citizen perceptions of police legitimacy.
Abstract: We undertook a systematic review and meta-analysis to synthesize the published and unpublished empirical evidence on the impact of police-led interventions that use procedurally just dialogue focused on improving citizen perceptions of police legitimacy. The systematic search included any public police intervention where there was a statement that the intervention involved police dialogue with citizens that either was aimed explicitly at improving police legitimacy, or used at least one core ingredient of procedural justice dialogue: police encouraging citizen participation, remaining neutral in their decision making, conveying trustworthy motives, or demonstrating dignity and respect throughout interactions. The studies included in our meta-analyses also had to include at least one direct outcome that measured legitimacy or procedural justice, or one outcome that is common in the legitimacy extant literature: citizen compliance, cooperation, confidence or satisfaction with police. We conducted separate meta-analyses, using random effects models, for each outcome. For every single one of our outcome measures, the effect of legitimacy policing was in a positive direction, and, for all but the legitimacy outcome, statistically significant. Notwithstanding the variability in the mode in which legitimacy policing is delivered (i.e., the study intervention) and the complexities around measurement of legitimacy outcomes, our review shows that the dialogue component of front-line police-led interventions is an important vehicle for promoting citizen satisfaction, confidence, compliance and cooperation with the police, and for enhancing perceptions of procedural justice. In practical terms, our research shows the benefits of police using dialogue that adopts at least one of the principles of procedural justice as a component part of any type of police intervention, whether as part of routine police activity or as part of a defined police crime control program. Our review provides evidence that legitimacy policing is an important precursor for improving the capacity of policing to prevent and control crime.
282 citations
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TL;DR: In this article, the authors argue that the former approach is more applicable to natural and semi-natural rivers where the primary objective and opportunity is ecological conservation, and the latter "designer" approach is better suited to modified and managed rivers where return to natural conditions is no longer feasible and the objective is to maximize natural capital as well as support economic growth, recreation, or cultural history.
Abstract: The term “environmental flows” describes the quantities, quality, and patterns of water flows required to sustain freshwater and estuarine ecosystems and the ecosystem services they provide. Environmental flows may be achieved in a number of different ways, most of which are based on either (1) limiting alterations from the natural flow baseline to maintain biodiversity and ecological integrity or (2) designing flow regimes to achieve specific ecological and ecosystem service outcomes. We argue that the former practice is more applicable to natural and semi-natural rivers where the primary objective and opportunity is ecological conservation. The latter “designer” approach is better suited to modified and managed rivers where return to natural conditions is no longer feasible and the objective is to maximize natural capital as well as support economic growth, recreation, or cultural history. This permits elements of ecosystem design and adaptation to environmental change. In a future characterized by altered climates and intensive regulation, where hybrid and novel aquatic ecosystems predominate, the designer approach may be the only feasible option. This conclusion stems from a lack of natural ecosystems from which to draw analogs and the need to support broader socioeconomic benefits and valuable configurations of natural and social capital.
282 citations
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TL;DR: In this paper, the authors explored the differential effect that internally oriented initiatives have on an organisation's human capital and its subsequent impact on the organisation's brand, from the employee's perspective.
Abstract: The creation of a strong brand and the deliverance of perceived service quality are premised by employees' ability to deliver on customer expectations. No consideration has been given, however, to understanding the ‘added value’ encapsulated in an organisation's brand as a result of the operant resources (skills and knowledge) supplied by the organisation's human capital. This paper, therefore, explores the differential effect that internally oriented initiatives have on an organisation's human capital and its subsequent impact on the organisation's brand, from the employee's perspective. In-depth interviews were conducted with employees across a range of service industries and the results provide an insight into the creation of employee brand commitment. Furthermore, this exploratory study provides a solid platform for future research in this area.
281 citations
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TL;DR: The design considerations of representative microfluidic devices for rare cell isolation and analysis and a perspective on the development trends and promising research directions in this field are proposed.
Abstract: Rare cells are low-abundance cells in a much larger population of background cells. Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells because of their generally low selectivity and significant sample loss. Recent rapid advances in microfluidics have been providing robust solutions to the challenges in the isolation and analysis of rare cells. In addition to the apparent performance enhancements resulting in higher efficiencies and sensitivity levels, microfluidics provides other advanced features such as simpler handling of small sample volumes and multiplexing capabilities for high-throughput processing. All of these advantages make microfluidics an excellent platform to deal with the transport, isolation, and analysis of rare cells. Various cellular biomarkers, including physical properties, dielectric properties, as well as immunoaffinities, have been explored for isolating rare cells. In this Focus article, we discuss the design considerations of representative microfluidic devices for rare cell isolation and analysis. Examples from recently published works are discussed to highlight the advantages and limitations of the different techniques. Various applications of these techniques are then introduced. Finally, a perspective on the development trends and promising research directions in this field are proposed.
281 citations
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Mayo Clinic1, Norwegian University of Science and Technology2, Goethe University Frankfurt3, National Research Council4, Stellenbosch University5, University of Milano-Bicocca6, University of Antwerp7, Flanders Institute for Biotechnology8, French Institute of Health and Medical Research9, university of lille10, University of Thessaly11, CERETETH12, Pierre-and-Marie-Curie University13, Casa Sollievo della Sofferenza14, Michael J. Fox Foundation15, GlaxoSmithKline16, Juntendo University17, Stanford University18, University of Ioannina19, Medical University of Silesia20, Seoul National University Hospital21, Hallym University22, University of Lübeck23, University of Tübingen24, Academy of Athens25, Centre national de la recherche scientifique26, National Taiwan University27, Mater Misericordiae University Hospital28, Griffith University29, Lund University30, University of Queensland31, Yonsei University32, University of British Columbia33, Karolinska Institutet34
TL;DR: The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent effects on disease risk, and are important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed.
Abstract: Summary Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of P arkinson’s disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the variants in PD susceptibility. Methods LRRK2 was genotyped in patients with PD and controls from three series (white, Asian, and Arab–Berber) from sites participating in the Genetic Epidemiology of Parkinson ’s Disease Consortium. Genotyping was done for exonic variants of LRRK2 that were identifi ed through searches of literature and the personal communications of consortium members. Associations with PD were assessed by use of logistic regression models. For variants that had a minor allele frequency of 0·5% or greater, single variant associations were assessed, whereas for rarer variants information was collapsed across variants. Findings 121 exonic LRRK2 variants were assessed in 15 540 individuals: 6995 white patients with PD and 5595 controls, 1376 Asian patients and 962 controls, and 240 Arab–Berber patients and 372 controls. After exclusion of carriers of known pathogenic mutations, new independent risk associations were identifi ed for polymorphic variants in white individuals (M1646T, odds ratio 1·43, 95% CI 1·15–1·78; p=0·0012) and Asian individuals (A419V, 2·27, 1·35–3·83; p=0·0011). A protective haplotype (N551K-R1398H-K1423K) was noted at a frequency greater than 5% in the white and Asian series, with a similar fi nding in the Arab–Berber series (combined odds ratio 0·82, 0·72–0·94; p=0·0043). Of the two previously reported Asian risk variants, G2385R was associated with disease (1·73, 1·20–2·49; p=0·0026), but no association was noted for R1628P (0·62, 0·36–1·07; p=0·087). In the Arab–Berber series, Y2189C showed potential evidence of risk association with PD (4·48, 1·33–15·09; p=0·012). Interpretation The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent eff ects on disease risk. LRRK2, and the pathway in which it functions, is important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed. These results will help discriminate those patients who will benefi t most from therapies targeted at LRRK2 pathogenic activity.
281 citations
Authors
Showing all 14162 results
Name | H-index | Papers | Citations |
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Rasmus Nielsen | 135 | 556 | 84898 |
Claudiu T. Supuran | 134 | 1973 | 86850 |
Jeffrey D. Sachs | 130 | 692 | 86589 |
David Smith | 129 | 2184 | 100917 |
Michael R. Green | 126 | 537 | 57447 |
John J. McGrath | 120 | 791 | 124804 |
E. K. U. Gross | 119 | 1154 | 75970 |
David M. Evans | 116 | 632 | 74420 |
Mike Clarke | 113 | 1037 | 164328 |
Wayne Hall | 111 | 1260 | 75606 |
Patrick J. McGrath | 107 | 681 | 51940 |
Peter K. Smith | 107 | 855 | 49174 |
Erko Stackebrandt | 106 | 633 | 68201 |
Phyllis Butow | 102 | 731 | 37752 |
John Quackenbush | 99 | 427 | 67029 |