Griffith University

About: Griffith University is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 13830 authors who have published 49318 publications receiving 1420865 citations.

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Abstract: Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibiting NLRP3 activation and inflammasome formation.

Removal of cement mortar remains from recycled aggregate using pre-soaking approaches

Abstract: With a rising tide of adoption of recycled aggregate (RA) for construction, investigation on ways to improve the quality of RA has been overwhelming. The adoption of RA brings benefits including savings in the limited landfill spaces and the use of natural resources. However, the poorer quality of RA often limits its utilization to low grade applications such as sub-grade activities, filling materials and low grade concrete. The major reason that affects the quality of RA is the large amount of cement mortar remains on the surface of the aggregate, resulting in higher porosity, water absorption rates and thus a weaker interfacial zone between new cement mortar and aggregates, which weakens the strength and mechanical performance of concrete made from RA. This paper attempts to study three pre-soaking treatment approaches; namely ReMortarHCl, ReMortarH2SO4 and ReMortarH3PO4 in reducing the mortar attached to RA. The results show that the behaviour of RA has improved with reduction in water absorption, without simultaneous exceeding the limits of chloride and sulphate compositions after the treatment. This work has also compared the compressive strength, flexural strength and modulus of elasticity of concrete made from the approaches, which shows marked improvements in quality when compared with those using traditional approaches.

Nature, race, and parks: past research and future directions for geographic research

Abstract: Geographic research on parks has been wide-ranging but has seldom examined how and why people use parks, leaving these questions to leisure science, which privileges socio-demographic variables over urban socio-spatial explanations (eg, historical, political-economic, and location factors). This article examines recent geographic perspectives on park use, drawing upon environmental justice, cultural landscape, and political ecology paradigms to redirect our attention from park users to a more critical appreciation of the historical, socio-ecological, and political-economic processes that operate through, and in turn shape, park spaces and park-going behaviors. We challenge partial, user-orientated approaches and suggest new directions for geographic research on parks.