Griffith University

About: Griffith University is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 13830 authors who have published 49318 publications receiving 1420865 citations.

Exploring internalized ableism using critical race theory

Abstract: This paper is an attempt to theorize about the way disabled people live with ableism, in particular internalized ableism. Typically literature within disability studies has concentrated on the practices and production of disablism, examining attitudes and barriers that contribute to the subordination of people with disabilities in society. My exploration occurs through examining the insights of critical race theory (CRT) and the contribution that CRT can further make to thinking through the processes, formation and consequences of ableism. A focal concern is the possible ways that the concept of internalized racism, its deployment in CRT and application to critical disability studies. The paper is interested in working through points of difference between the way internalized racism/ableism are mediated in the processes of subjectification and identifying points of convergence that can benefit dialogue across varied sites of scholarship. The author concludes that the study of ableism instead of disability...

Density functional theory analysis of structural and electronic properties of orthorhombic perovskite CH3NH3PbI3

Abstract: The organic–inorganic hybrid perovskite CH3NH3PbI3 is a novel light harvester, which can greatly improve the solar-conversion efficiency of dye-sensitized solar cells. In this article, a first-principle theoretical study is performed using local, semi-local and non-local exchange–correlation approximations to find a suitable method for this material. Our results, using the non-local optB86b + vdWDF functional, excellently agree with the experimental data. Thus, consideration of weak van der Waals interactions is demonstrated to be important for the accurate description of the properties of this type of organic–inorganic hybrid materials. Further analysis of the electronic properties reveals that I 5p electrons can be photo-excited to Pb 6p empty states. The main interaction between the organic cations and the inorganic framework is through the ionic bonding between CH3 and I ions. Furthermore, I atoms in the Pb–I framework are found to be chemically inequivalent because of their different chemical environments.

Best practice in couple relationship education.

Abstract: Relationship education is widely available to couples and is intended to reduce the prevalence of relationship distress, divorce, and the associated personal and social costs. To realize the potential benefits of couple relationship education, it needs to be evidence-based, offered in ways that attract couples at high-risk for relationship problems, and focused on factors that put couples at high-risk for future relationship problems.

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

Abstract: Migraine with aura is a common, debilitating, recurrent headache disorder associated with transient and reversible focal neurological symptoms. A role has been suggested for the two-pore domain (K2P) potassium channel, TWIK-related spinal cord potassium channel (TRESK, encoded by KCNK18), in pain pathways and general anaesthesia. We therefore examined whether TRESK is involved in migraine by screening the KCNK18 gene in subjects diagnosed with migraine. Here we report a frameshift mutation, F139WfsX24, which segregates perfectly with typical migraine with aura in a large pedigree. We also identified prominent TRESK expression in migraine-salient areas such as the trigeminal ganglion. Functional characterization of this mutation demonstrates that it causes a complete loss of TRESK function and that the mutant subunit suppresses wild-type channel function through a dominant-negative effect, thus explaining the dominant penetrance of this allele. These results therefore support a role for TRESK in the pathogenesis of typical migraine with aura and further support the role of this channel as a potential therapeutic target.

Developing New Antimicrobial Therapies: Are Synergistic Combinations of Plant Extracts/Compounds with Conventional Antibiotics the Solution?

Abstract: The discovery of penicillin nearly 90 years ago revolutionized the treatment of bacterial disease Since that time, numerous other antibiotics have been discovered from bacteria and fungi, or developed by chemical synthesis and have become effective chemotherapeutic options However, the misuse of antibiotics has lessened the efficacy of many commonly used antibiotics The emergence of resistant strains of bacteria has seriously limited our ability to treat bacterial illness, and new antibiotics are desperately needed Since the discovery of penicillin, most antibiotic development has focused on the discovery of new antibiotics derived from microbial sources, or on the synthesis of new compounds using existing antibiotic scaffolds to the detriment of other lines of discovery Both of these methods have been fruitful However, for a number of reasons discussed in this review, these strategies are unlikely to provide the same wealth of new antibiotics in the future Indeed, the number of newly developed antibiotics has decreased dramatically in recent years Instead, a reexamination of traditional medicines has become more common and has already provided several new antibiotics Traditional medicine plants are likely to provide further new antibiotics in the future However, the use of plant extracts or pure natural compounds in combination with conventional antibiotics may hold greater promise for rapidly providing affordable treatment options Indeed, some combinational antibiotic therapies are already clinically available This study reviews the recent literature on combinational antibiotic therapies to highlight their potential and to guide future research in this field