Showing papers by "Guy's and St Thomas' NHS Foundation Trust published in 1993"
TL;DR: Delivery to osteocalcin-producing osteoblasts seemed impaired in patients with the low receptor-affinity apolipoprotein variant E2, suggesting a major role of receptor-mediated chylomicron-remnant uptake in the transport of phylloquinone to bone.
94 citations
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6 citations
TL;DR: A broad definition of acute liver failure is severe hepatic dysfunction, manifest by either encephalopathy or a coagulopathy, developing within 6 months of the first related symptoms and in the absence of pre-existing liver disease.
Abstract: A broad definition of acute liver failure is severe hepatic dysfunction, manifest by either encephalopathy or a coagulopathy, developing within 6 months of the first related symptoms and in the absence of pre-existing liver disease. Of the systems proposed to classify acute liver failure into subgroups that reflect variations in the natural history and clinical features, that are at least in part related to the tempo of the condition, two are extensively used (Fig. 37.1). The first subdivides acute liver failure into fulminant and late-onset (previously subacute) hepatic failure if encephalopathy develops within or in excess of 8 weeks of the onset of symptoms, respectively [31]. The second system utilizes the interval between the onset of jaundice and encephalopathy, and fulminant hepatic failure denotes a duration of up to 2 weeks while sub-fulminant hepatic failure is between 2 weeks and 3 months [2].
2 citations