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Institution

Guy's and St Thomas' NHS Foundation Trust

HealthcareLondon, United Kingdom
About: Guy's and St Thomas' NHS Foundation Trust is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 7686 authors who have published 9631 publications receiving 399353 citations. The organization is also known as: Guy's and St Thomas' National Health Service Foundation Trust & Guy's and St Thomas' National Health Service Trust.


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Journal ArticleDOI
Richard Anney1, Lambertus Klei2, Dalila Pinto3, Dalila Pinto4, Joana Almeida, Elena Bacchelli5, Gillian Baird6, Nadia Bolshakova1, Sven Bölte7, Patrick Bolton8, Thomas Bourgeron9, Thomas Bourgeron10, Sean Brennan1, Jessica Brian4, Jillian P. Casey11, Judith Conroy11, Catarina Correia12, Catarina Correia13, Christina Corsello14, Emily L. Crawford15, Maretha de Jonge16, Richard Delorme, Eftichia Duketis7, Frederico Duque, Annette Estes17, Penny Farrar18, Bridget A. Fernandez19, Susan E. Folstein20, Eric Fombonne21, John R. Gilbert20, Christopher Gillberg22, Joseph T. Glessner23, Andrew Green11, Jonathan Green24, Stephen J. Guter25, Elizabeth A. Heron1, Richard Holt18, Jennifer L. Howe4, Gillian Hughes1, Vanessa Hus14, Roberta Igliozzi, Suma Jacob25, Graham Kenny1, Cecilia Kim23, Alexander Kolevzon3, Vlad Kustanovich, Clara Lajonchere, Janine A. Lamb24, Miriam Law-Smith1, Marion Leboyer10, Ann Le Couteur26, Bennett L. Leventhal27, Bennett L. Leventhal28, Xiao-Qing Liu29, Frances Lombard1, Catherine Lord30, Linda Lotspeich31, Sabata C. Lund15, Tiago R. Magalhaes13, Tiago R. Magalhaes12, Carine Mantoulan32, Christopher J. McDougle33, Christopher J. McDougle34, Nadine M. Melhem2, Alison K. Merikangas1, Nancy J. Minshew2, Ghazala Mirza18, Jeff Munson17, Carolyn Noakes4, Gudrun Nygren22, Katerina Papanikolaou35, Alistair T. Pagnamenta18, Barbara Parrini, Tara Paton4, Andrew Pickles24, David J. Posey34, Fritz Poustka7, Jiannis Ragoussis18, Regina Regan11, Wendy Roberts4, Kathryn Roeder36, Bernadette Rogé32, Michael Rutter37, Sabine Schlitt7, Naisha Shah11, Val C. Sheffield38, Latha Soorya3, Inês Sousa18, Vera Stoppioni, Nuala Sykes18, Raffaella Tancredi, Ann P. Thompson39, Susanne Thomson15, Ana Tryfon3, John Tsiantis35, Herman van Engeland16, John B. Vincent4, Fred R. Volkmar40, Jacob A. S. Vorstman16, Simon Wallace18, Kirsty Wing18, Kerstin Wittemeyer18, Shawn Wood2, Danielle Zurawiecki3, Lonnie Zwaigenbaum41, Anthony J. Bailey42, Agatino Battaglia, Rita M. Cantor43, Hilary Coon44, Michael L. Cuccaro20, Geraldine Dawson45, Geraldine Dawson46, Sean Ennis11, Christine M. Freitag7, Daniel H. Geschwind43, Jonathan L. Haines47, Sabine M. Klauck48, William M. McMahon44, Elena Maestrini5, Judith Miller44, Judith Miller23, Anthony P. Monaco18, Anthony P. Monaco49, Stanley F. Nelson43, John I. Nurnberger34, Guiomar Oliveira, Jeremy R. Parr26, Margaret A. Pericak-Vance20, Joseph Piven45, Gerard D. Schellenberg23, Stephen W. Scherer4, Astrid M. Vicente13, Astrid M. Vicente12, Thomas H. Wassink38, Ellen M. Wijsman17, Catalina Betancur50, Catalina Betancur51, Catalina Betancur52, Joseph D. Buxbaum3, Edwin H. Cook25, Louise Gallagher1, Michael Gill1, Joachim Hallmayer31, Andrew D. Paterson4, James S. Sutcliffe15, Peter Szatmari39, Veronica J. Vieland53, Hakon Hakonarson23, Bernie Devlin2 
Trinity College, Dublin1, University of Pittsburgh2, Icahn School of Medicine at Mount Sinai3, University of Toronto4, University of Bologna5, Guy's and St Thomas' NHS Foundation Trust6, Goethe University Frankfurt7, King's College London8, Pasteur Institute9, University of Paris10, University College Dublin11, Instituto Gulbenkian de Ciência12, University of Lisbon13, University of Michigan14, Vanderbilt University15, Utrecht University16, University of Washington17, University of Oxford18, Memorial University of Newfoundland19, University of Miami20, McGill University21, University of Gothenburg22, University of Pennsylvania23, University of Manchester24, University of Illinois at Chicago25, Newcastle University26, Nathan Kline Institute for Psychiatric Research27, New York University28, University of Manitoba29, Cornell University30, Stanford University31, University of Toulouse32, Harvard University33, Indiana University34, National and Kapodistrian University of Athens35, Carnegie Mellon University36, Medical Research Council37, University of Iowa38, McMaster University39, Yale University40, University of Alberta41, University of British Columbia42, University of California, Los Angeles43, University of Utah44, University of North Carolina at Chapel Hill45, Autism Speaks46, Veterans Health Administration47, German Cancer Research Center48, Tufts University49, Pierre-and-Marie-Curie University50, French Institute of Health and Medical Research51, Centre national de la recherche scientifique52, Ohio State University53
TL;DR: Stage 2 of the Autism Genome Project genome-wide association study is reported, adding 1301 ASD families and bringing the total to 2705 families analysed, and it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
Abstract: While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.

353 citations

Journal ArticleDOI
TL;DR: The PROCESS Guideline, consisting of an eight item checklist that will improve the reporting quality of surgical case series is presented and authors, reviewers, editors, journals, publishers and the wider surgical and scholarly community are encouraged to adopt these.

349 citations

Journal ArticleDOI
TL;DR: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.
Abstract: BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk. British Journal of Cancer (2011) 105, 709-722. doi:10.1038/bjc.2011.254 www.bjcancer.com Published online 19 July 2011 (C) 2011 Cancer Research UK

347 citations

Journal ArticleDOI
TL;DR: The pattern and pathophysiology of DNP toxicity is described, the previous fatalities associated with exposure to DNP are summarised and the current and previous fatalities related to exposure are summarized.
Abstract: 2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death. Fatalities related to exposure to DNP have been reported since the turn of the twentieth century. To date, there have been 62 published deaths in the medical literature attributed to DNP. In this review, we will describe the pattern and pathophysiology of DNP toxicity and summarise the previous fatalities associated with exposure to DNP.

346 citations

Journal ArticleDOI
TL;DR: A new syndrome associated with the ChAdOx1 nCoV-19 adenoviral vector vaccine against severe acute respiratory sy... is a new disease associated with vaccine-induced immune thrombocytopenia (VITT).
Abstract: Background Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a new syndrome associated with the ChAdOx1 nCoV-19 adenoviral vector vaccine against severe acute respiratory sy...

341 citations


Authors

Showing all 7765 results

NameH-indexPapersCitations
Christopher J L Murray209754310329
Bruce M. Psaty1811205138244
Giuseppe Remuzzi1721226160440
Mika Kivimäki1661515141468
Simon I. Hay165557153307
Theo Vos156502186409
Ali H. Mokdad156634160599
Steven Williams144137586712
Igor Rudan142658103659
Mohsen Naghavi139381169048
Christopher D.M. Fletcher13867482484
Martin McKee1381732125972
David A. Jackson136109568352
Graham G. Giles136124980038
Yang Liu1292506122380
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202316
202298
20211,488
20201,123
2019829
2018767