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Institution

Guy's and St Thomas' NHS Foundation Trust

HealthcareLondon, United Kingdom
About: Guy's and St Thomas' NHS Foundation Trust is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 7686 authors who have published 9631 publications receiving 399353 citations. The organization is also known as: Guy's and St Thomas' National Health Service Foundation Trust & Guy's and St Thomas' National Health Service Trust.


Papers
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Journal ArticleDOI
TL;DR: Characterization of a cohort of children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection provides insights into the immunopathogenic features of the disease.
Abstract: Recent reports highlight a new clinical syndrome in children related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1—multisystem inflammatory syndrome in children (MIS-C)—which comprises multiorgan dysfunction and systemic inflammation2–13. We performed peripheral leukocyte phenotyping in 25 children with MIS-C, in the acute (n = 23; worst illness within 72 h of admission), resolution (n = 14; clinical improvement) and convalescent (n = 10; first outpatient visit) phases of the illness and used samples from seven age-matched healthy controls for comparisons. Among the MIS-C cohort, 17 (68%) children were SARS-CoV-2 seropositive, suggesting previous SARS-CoV-2 infections14,15, and these children had more severe disease. In the acute phase of MIS-C, we observed high levels of interleukin-1β (IL-1β), IL-6, IL-8, IL-10, IL-17, interferon-γ and differential T and B cell subset lymphopenia. High CD64 expression on neutrophils and monocytes, and high HLA-DR expression on γδ and CD4+CCR7+ T cells in the acute phase, suggested that these immune cell populations were activated. Antigen-presenting cells had low HLA-DR and CD86 expression, potentially indicative of impaired antigen presentation. These features normalized over the resolution and convalescence phases. Overall, MIS-C presents as an immunopathogenic illness1 and appears distinct from Kawasaki disease. Characterization of a cohort of children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection provides insights into the immunopathogenic features of the disease.

288 citations

Journal ArticleDOI
TL;DR: This work estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods and used the cohort-component method of population projection, with inputs of fertility, mortality, population, and migration data.

287 citations

Journal ArticleDOI
TL;DR: The epidemiology and the public health response for the first diagnosed cases of monkeypox outside the African continent since 2003 are described.
Abstract: In early September 2018, two cases of monkeypox were reported in the United Kingdom (UK), diagnosed on 7 September in Cornwall (South West England) and 11 September in Blackpool (North West England). The cases were epidemiologically unconnected and had recently travelled to the UK from Nigeria, where monkeypox is currently circulating. We describe the epidemiology and the public health response for the first diagnosed cases outside the African continent since 2003.

286 citations

Journal ArticleDOI
TL;DR: Quadriceps wasting exists in patients with mild, as well as advanced, COPD, and is independently associated with physical inactivity in GOLD stage I disease, where residual volume to total lung capacity ratio was the only independent predictor of physical activity level.
Abstract: Background: respiratory tract injury is the major cause of morbimortality in Cystic fibrosis (CF) patients. Gastroesophageal reflux disease (GORD) might contribute to lung function decline and progression of pulmonary disease in them. Despite the increased gastroesophageal reflux (GOR) symptoms in CF patients, its prevalence and association with gastric aspiration and respiratory impact are not well characterized. Aim: assess prevalence of GORD in CF adults, and study possible associations with genotypes, specific colonizations, lung disease severity and GORD treatment. Methods: retrospective study conducted in 23 CF patients attended at Pneumology Unit of Coimbra University Hospital, through a direct questionnaire (adapted from Mayo GER Questionnaire) concerning GERD symptoms in previous 12 months. Results: Of 23 studied patients, mean age 30 ± 7,6, 70% female; DF508 homozygote was the most frequent genotype. P. Aeruginosa and S.Aureus organisms were the most prevalent pulmonary colonization. In 48% lung function was severely depressed. 21 patients (91%) experienced at least one GERD symptom, 12 (57%) referred the occurrence of 5 or more. Concerning lung function severity, we established significant statistical difference between groups under treatment versus untreated group, being the first the one that presented the worst CVF values (p=0,032). Conclusions: despite the limited evidence that GERD adversely impacts lung function,the possibility that acid suppression improves the outcome of this patients, leads to a strong recommendation for aggressive treatment of GERD. However, according to our study, acid suppression treatment might be insufficient, turning it in a contemporary and scientifically important subject.

286 citations

Journal Article
TL;DR: This study demonstrates that direct DNA diagnosis establishes the genotype at the FRAXA-FMR-1 locus, and validate the use of direct DNA testing for fragile X diagnosis as well as for carrier identification and support and complete the established relationships among the DNA results and the cytogenetic, physical, and psychological aspects of the disease.
Abstract: We report the results of a 14-center collaborative study of genotype-phenotype correlations in 318 fragile X families; these families comprised 2,253 individuals, 1,344 of whom carried a fragile X mutation and 693 of whom had a typical full fragile X mutation This study demonstrates that direct DNA diagnosis establishes the genotype at the FRAXA-FMR-1 locus There was a significantly higher prevalence of “mosaic” cases among males who carry a full mutation (12%) than among females who carry a full mutation (6%); the mosaic males had a larger expansion than did the mosaic females Mental status of premutated individuals did not differ from that of those with a normal genotype Both the abnormal methylation of the FMR-1–EagI site and the size of the expansion were highly correlated with cytogenetics, facial dysmorphism, macroorchidism, and mental retardation (MR) Among female carriers of a full mutation, those with MR had significantly larger expansion than did those without MR Among 164 independent couples, 3 unrelated husbands carried a premutation that suggests that the prevalence of fragile X premutations in the general population is ~09% of the X chromosomes Our data validate the use of direct DNA testing for fragile X diagnosis as well as for carrier identification and support and complete the established relationships among the DNA results and the cytogenetic, physical, and psychological aspects of the disease

285 citations


Authors

Showing all 7765 results

NameH-indexPapersCitations
Christopher J L Murray209754310329
Bruce M. Psaty1811205138244
Giuseppe Remuzzi1721226160440
Mika Kivimäki1661515141468
Simon I. Hay165557153307
Theo Vos156502186409
Ali H. Mokdad156634160599
Steven Williams144137586712
Igor Rudan142658103659
Mohsen Naghavi139381169048
Christopher D.M. Fletcher13867482484
Martin McKee1381732125972
David A. Jackson136109568352
Graham G. Giles136124980038
Yang Liu1292506122380
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202316
202298
20211,488
20201,123
2019829
2018767