Institution
Guy's and St Thomas' NHS Foundation Trust
Healthcare•London, United Kingdom•
About: Guy's and St Thomas' NHS Foundation Trust is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 7686 authors who have published 9631 publications receiving 399353 citations. The organization is also known as: Guy's and St Thomas' National Health Service Foundation Trust & Guy's and St Thomas' National Health Service Trust.
Papers published on a yearly basis
Papers
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TL;DR: Sarcopenia was more prevalent after neoadjuvant chemotherapy, and loss of FM, differential loss of VA/SA and skeletal muscle were associated with risk of CRM positivity, while changes in body composition did not affect perioperative complications and survival.
Abstract: Objectives
Sarcopenia and changes in body composition following neoadjuvant chemotherapy (NAC) may affect clinical outcome. We assessed the associations between CT body composition changes following NAC and outcomes in oesophageal cancer.
173 citations
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TL;DR: The finding that age-related reduction in SDQ symptoms does not apply when ASD-specific cut-offs are used requires further evaluation using diagnostic measures, raising the possibility that the causes of psychopathology in ASD differ from those in the general population.
Abstract: Background: Psychiatric problems are common in autism spectrum disorders (ASDs), but the reasons are poorly understood. We use a longitudinal population-representative cohort to examine for the first time the persistence of psychiatric problems and to identify risk factors for their occurrence and stability.
Methods: Eighty-one 16-year olds (75 male, six female), initially seen at 12 years, were re-assessed using the parent-report Strengths and Difficulties Questionnaire (SDQ). Child, family and contextual characteristics from age 12 were tested as risk factors for psychopathology.
Results: Prevalence rates varied depending on whether general population or ASD-specific SDQ cut-offs were used. While the former suggested a decrease in psychiatric problems over time, the ASD-specific cut-offs showed no significant differences. With the exception of ADHD, the ASD-specific cut-offs identified a smaller proportion of individuals as ‘affected’ than did the general population cut-offs. There was longitudinal domain specificity, with parent correlations ranging from 0.50 to 0.58 and teacher SDQ reports at age 12 correlating 0.33–0.53 with parent reports at 16 years. In examining the role of risk factors, lower IQ and adaptive functioning predicted higher hyperactivity and total difficulties scores. Greater emotional problems at 16 were predicted by poorer maternal mental health, family-based deprivation and lower social class. Improvement from 12 to 16 years in conduct problems was predicted by greater neighbourhood deprivation and special school attendance.
Conclusions: This is the first longitudinal study of other psychiatric symptoms in ASD. Additional psychiatric problems in ASD are persistent and domain-specific from childhood to adolescence. The finding that age-related reduction in SDQ symptoms does not apply when ASD-specific cut-offs are used requires further evaluation using diagnostic measures. Only a few of the expected risk factor-psychopathology predictions expected from general population studies were found, raising the possibility that the causes of psychopathology in ASD differ from those in the general population.
173 citations
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TL;DR: Age was associated with an increase in esophageal acid exposure; however, the severity of reflux symptoms reduced with age, and changes were associated with progressive decrease in abdominal LES length and esphageal motility.
171 citations
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Institute for Health Metrics and Evaluation1, University of Limoges2, University College Hospital, Ibadan3, Obafemi Awolowo University4, Tehran University of Medical Sciences5, Mayo Clinic6, Cleveland Clinic7, Iran University of Medical Sciences8, Essentia Health9, Georgia Regents University10, Babol University of Medical Sciences11, Karolinska Institutet12, University of Porto13, University of Washington14, Mazandaran University of Medical Sciences15, Federal University of Bahia16, University of Louisville17, Kaiser Permanente18, A.T. Still University19, University of North Carolina at Chapel Hill20, Hamdan bin Mohammed e-University21, University of Ibadan22, Shahid Beheshti University of Medical Sciences and Health Services23, University of Tartu24, University of Cape Town25, Medical Research Council26, University of South Carolina27, KISA28, Metropolitan University29, Brown University30, University of Manitoba31, University of Virginia32, National Institutes of Health33, Kyrgyz State Medical Academy34, King Saud University35, Carol Davila University of Medicine and Pharmacy36, Duy Tan University37, Maimonides Medical Center38, University of Bern39, Imperial College London40, University College London41, Public Health England42, West Virginia University43, Ain Shams University44, Adigrat University45, Hanoi Medical University46, Gomal University47, Harvard University48, King's College London49, Guy's and St Thomas' NHS Foundation Trust50
TL;DR: These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults, with highest age-standardized DALY rates of CAVD estimated for high-income countries.
Abstract: Background: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence,...
171 citations
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University of Liverpool1, Boston Children's Hospital2, Great Ormond Street Hospital3, Royal Hospital for Sick Children4, University Hospitals Bristol NHS Foundation Trust5, Norfolk and Norwich University Hospital6, Guy's and St Thomas' NHS Foundation Trust7, University College London Hospitals NHS Foundation Trust8, Musgrove Park Hospital9, University Hospital Coventry10
TL;DR: The data on these patients from the UK JSLE Cohort Study indicate that severe organ involvement and significant disease activity are primary characteristics in children with juvenile SLE.
Abstract: Objective
The UK Juvenile-Onset Systemic Lupus Erythematosus (JSLE) Cohort Study is a multicenter collaborative network established with the aim of improving the understanding of juvenile SLE. The present study was undertaken to describe the clinical manifestations and disease course in patients with juvenile SLE from this large, national inception cohort.
Methods
Detailed data on clinical phenotype were collected at baseline and at regular clinic reviews and annual followup assessments in 232 patients from 14 centers across the UK over 4.5 years. Patients with SLE were identified according to the American College of Rheumatology (ACR) SLE classification criteria. The present cohort comprised children with juvenile SLE (n = 198) whose diagnosis fulfilled ≥4 of the ACR criteria for SLE.
Results
Among patients with juvenile SLE, the female:male sex distribution was 5.6:1 and the median age at diagnosis was 12.6 years (interquartile range 10.4–14.5 years). Male patients were younger than female patients (P < 0.01). Standardized ethnicity data demonstrated a greater risk of juvenile SLE in non-Caucasian UK patients (P < 0.05). Scores on the pediatric adaptation of the 2004 British Isles Lupus Assessment Group disease activity index demonstrated significantly increased frequencies of musculoskeletal (82%), renal (80%), hematologic (91%), immunologic (54%), and neurologic (26%) involvement among the patients over time. A large proportion of the patients (93%) were taking steroids and 24% of the patients required treatment with cyclophosphamide. Disease damage was common, with 28% of the patients having a Systemic Lupus International Collaborating Clinics/ACR damage score of ≥1.
Conclusion
The data on these patients from the UK JSLE Cohort Study, comprising one of the largest national inception cohorts of patients with juvenile SLE to date, indicate that severe organ involvement and significant disease activity are primary characteristics in children with juvenile SLE. In addition, accumulation of disease-associated damage could be seen.
171 citations
Authors
Showing all 7765 results
Name | H-index | Papers | Citations |
---|---|---|---|
Christopher J L Murray | 209 | 754 | 310329 |
Bruce M. Psaty | 181 | 1205 | 138244 |
Giuseppe Remuzzi | 172 | 1226 | 160440 |
Mika Kivimäki | 166 | 1515 | 141468 |
Simon I. Hay | 165 | 557 | 153307 |
Theo Vos | 156 | 502 | 186409 |
Ali H. Mokdad | 156 | 634 | 160599 |
Steven Williams | 144 | 1375 | 86712 |
Igor Rudan | 142 | 658 | 103659 |
Mohsen Naghavi | 139 | 381 | 169048 |
Christopher D.M. Fletcher | 138 | 674 | 82484 |
Martin McKee | 138 | 1732 | 125972 |
David A. Jackson | 136 | 1095 | 68352 |
Graham G. Giles | 136 | 1249 | 80038 |
Yang Liu | 129 | 2506 | 122380 |