Showing papers by "Hai phong University Of Medicine and Pharmacy published in 2009"
Journal Article•
TL;DR: Estimation of VEGF expression and its receptors became a reliable prognostic tool in OSCCS, predicting the poor disease-free survival, poor overall survival, and metastatic disease.
Abstract: Oral cancer is an important cause of worldwide morbidity and mortality, with substantial economic, physiological, and psychosocial impacts due to its treatment modality and a great risk for recurrences and second primary oral squamous cell carcinomas (OSCC) development. Therefore, it is very important to understand the underlying cell biology of such tumors. It is now a well-accepted fact that angiogenesis is essential for the growth and metastasis of solid tumors, including head and neck squamous cell carcinoma. The main factor responsible for angiogenesis is VEGF and its receptors. It has been demonstrated that VEGFRs are also present on tumor cells themselves and other cells from the tumor microenvironment, in addition to tumoral endothelial cells (ECs). Therefore between these cells take place numerous and different interactions mediated via paracrine/autocrine pathways that promote angiogenesis, uncontrolled tumor proliferation and metastasation. In consequence, estimation of VEGF expression and its receptors became a reliable prognostic tool in OSCCS, predicting the poor disease-free survival, poor overall survival, and metastatic disease. Understanding the distribution and role of VEGF and its receptors in the progression of OSCC will be essential to the development and design of new therapeutic strategies.
39 citations
TL;DR: LA and to an even greater degree DHLA were able to protect the membranes of red blood cells because of their ability to scavenge free radicals, suggesting that LA and D HLA might be useful in the treatment of diseases associated with oxidative stress such as diabetes.
Abstract: The aim of our work was to study (1) the antioxidant properties of lipoic acid (LA) and its reduced metabolite dihydrolipoic acid (DHLA) formed by reduction of LA and (2) the effects of treatment with LA and DHLA on (a) K(+) efflux from human red blood cells and (b) post-ischemic recovery and oxidative stress in isolated perfused rat hearts challenged with an ischemia-reperfusion (IR) sequence. In vitro, we used xanthine and xanthine oxidase to generate superoxide anion, which is not directly measurable by electron paramagnetic resonance (EPR), but specifically oxidizes the spin probe CPH into an EPR-detectable long lasting CP(*) nitroxide radical. While 5 mM of LA was ineffective in reducing the kinetics of CP(*) nitroxide formation, DHLA was shown to lessen this rate in a dose-dependent manner and at 30 mM was even more efficient than 300 UI/ml SOD. These results are in agreement with the fact that DHLA is able to directly scavenge superoxide anion. Red cells are a good model to investigate oxidative damage in biological membranes; hence, we used a suspension of erythrocytes incubated with 2,2(')-azobis(2-amidinopropane) hydrochloride (AAPH) which generates in vitro free radicals. DHLA provided more effective protection of red cells membranes than LA; DHLA was comparable to Trolox for its antioxidant potency. In vivo, treatment of rats (50 mg/kg/day i.p. for 7 days) with LA induced a slight increase in coronary flow (CF) in isolated perfused hearts, after 30 min of global total ischemia. This effect was not associated with an improvement in contractile function and reduction of myocardial oxidative stress. In conclusion, because of their ability to scavenge free radicals, LA and to an even greater degree DHLA were able to protect the membranes of red blood cells. This finding suggests that LA and DHLA might be useful in the treatment of diseases associated with oxidative stress such as diabetes.
36 citations
TL;DR: In this paper, the Navier-Stokes equations of a viscous and electrically conducting fluid obliquely impinging on a flat plate in the presence of a uniform applied magnetic field was formulated as a similarity solution of the Naviers-Stoke equations.
Abstract: Laminar two-dimensional stagnation flow of a viscous and electrically conducting fluid obliquely impinging on a flat plate in the presence of a uniform applied magnetic field is formulated as a similarity solution of the Navier-Stokes equations. The relative importance of this flow is measured by the dimensionless strain rate and magnetohydrodynamic parameters γ and M. The viscous problem is reduced to a coupled pair of ordinary differential equations governed by γ and M. It is found that the parameter M causes a shift in the position of the point of zero skin friction along the wall.
35 citations
TL;DR: In this paper, the thermal properties of two typical actuators of intelligent systems (Ni-Ti SMA cantilever and SMA helical spring) are evaluated for thermal analysis experiments.
Abstract: For two typical actuators of intelligent systems (Ni–Ti SMA cantilever and SMA helical spring), the evaluation of their thermal characteristics is presented. In order to determine the transformation temperatures and other thermal parameters of the two studied elements, the attention was concentrated on thermal analysis experiments. For each actuator configuration, comprehensive graphical interfaces have been developed, to run in Visual Basic, with respect to the results of performed thermal analyses.
31 citations
TL;DR: The CT truncated cone formula applies best for precise evaluation of trapezoidal shape alteration in dilated AF atria and there is a good correlation between CTtr and echocardiography which remains a valuable estimation for volume calculation in clinical practice.
Abstract: Assessment of volume in relation with left atrial (LA) shape alteration before and after PV isolation. We compared trapezoidal modification of LA using echocardiography with the ellipsoid formula (Eel) and CT, with both ellipsoid (CTel) and truncated cone formulas (CTtr), in 40 patients, before and ±3 months after AF ablation. A trapezoidal shape was present in 76.3% of patients. The different volume measurements were statistically correlated (r = 0.603–0.837, p < 0.001) irrespective of the formula used. After reverse remodeling, with 77.5% of patients in stable sinus rhythm, correlation coefficient for volume remained significant (p < 0.001). In AF, dilation of the LA is associated with a geometrical trapezoidal change in many cases. The CT truncated cone formula applies best for precise evaluation of trapezoidal shape alteration in dilated AF atria. There is a good correlation between CTtr and echocardiography which remains a valuable estimation for volume calculation in clinical practice.
16 citations
TL;DR: The prevalent HBV subgenotypes in patients with acute hepatitis B in Central Vietnam were B4/Ba and C1/Cs and BCP/PC variants have an association with the development of fulminant hepatic failure in subgenotype B 4/Ba.
Abstract: Objective: Hepatitis B virus (HBV) has been classified into 8 genotypes that have different geographic distributions. The clinical outcomes of acute hepatitis are dependent on genotype. The aim of this study was to investigate the distribution of HBV subgenotypes and basal core promoter (BCP)/precore (PC) regions in acute hepatitis patients in Central Vietnam to clarify the distributions and the clinical and virological differences. Methods: 27 patients with acute hepatitis B were studied. HBV subgenotypes and BCP/PC variants were determined by direct sequencing of the preS, BCP/PC regions, respectively. Results: HBV subgenotypes B4/Ba (n = 22) and C1/Cs (n = 5) were detected. Of the 27 patients, 3 developed fulminant hepatic failure, and all were infected with B4/Ba. Three patients had a BCP mutation, and 10 patients had a PC mutation in subgenotype B4/Ba. Three patients with C1/Cs had a BCP mutation. Two of 3 patients who progressed to fulminant hepatic failure had T1762, A1764, and A1896 simultaneously. None of the patients with acute, self-limited hepatitis carried these triple mutations. Conclusion: The prevalent HBV subgenotypes in patients with acute hepatitis B in Central Vietnam were B4/Ba and C1/Cs. BCP/PC variants have an association with the development of fulminant hepatic failure in subgenotype B4/Ba.
15 citations
TL;DR: This paper contains the Central European Vaccination Advisory Group (CEVAG) guidance statement on the introduction of HPV vaccines in central Europe, which may be adapted for use in individual countries.
Abstract: Vaccines against human papillomavirus (HPV), the primary causative agent in cervical cancer, are licensed. This paper contains the Central European Vaccination Advisory Group (CEVAG) guidance statement on the introduction of HPV vaccines in central Europe. Eight countries currently have medical representatives on CEVAG: the Czech Republic, Estonia, Hungary, Lithuania, Poland, Romania, Slovakia and Turkey. By raising awareness and disseminating information, CEVAG aims to promote the efficient and safe use of vaccines to prevent, control and if possible eliminate infectious diseases. In January 2008, the European Centre for Disease Prevention and Control published a report entitled Guidance for the Introduction of HPV Vaccines in EU Countries. Members of CEVAG have taken the information relevant to their countries from this report and, with consideration of local issues, produced these guidance recommendations for the introduction of HPV vaccines in the CEVAG region, which may be adapted for use in individual countries.
10 citations
01 Jan 2009
TL;DR: This paper presents some general design patterns for databases in Healthcare Information Systems, with emphasis on the generalization capacity of the database structure, which is able to serve other medical specializations, with no compromises for the integration of the entire system.
Abstract: This paper presents some general design patterns for databases in Healthcare Information Systems. The presented solutions were validated in a research project for early diagnosis and treatment of the patients with major risk of esophageal and gastric cancer. Our emphasis is on the generalization capacity of the database structure, which is able to serve other medical specializations, with no compromises for the integration of the entire system.
10 citations
01 Jan 2009
TL;DR: A brief review of the problem of controlling airborne disease transmission in healthcare facilities with emphasis on medical microbiology and aerobiology is provided in order to offer some conclusions regarding the potential for engineering control of infectious diseases.
Abstract: Hospital acquired illness or “nosocomial” illness is of increasing concern to public health administrators, hospitals, physicians and patients. Engineering infection control measures are used to reduce the concentration and prevent the spread of these particles throughout a building in order to decrease exposure to and risk of illness from infectious pathogens. The engineer who attempts to deal with microbial indoor air quality finds that pertinent microbiological information exists in abundance but not in easily digestible forms. This paper will provide a brief review of the problem of controlling airborne disease transmission in healthcare facilities with emphasis on medical microbiology and aerobiology in order to offer some conclusions regarding the potential for engineering control of infectious diseases.
6 citations
TL;DR: In this paper, the crystal structures of dinitrato(2-formylpyridinesemicarbazone)copper (I), dichloro(2 -formyl pyridineemic)-bazone (II), and bis(2 −pyridisemic)-cubic perchlorate hydrate (III) perchlorates were determined.
Abstract: Compounds dinitrato(2-formylpyridinesemicarbazone)copper (I), dichloro(2-formylpyridinesemicarbazone) copper hemihydrate (II), and bis(2-formylpyridinesemicarbazone)copper(2+) perchlorate hydrate (III) are synthesized and their crystal structures are determined. In compounds I–III, the neutral 2-formylpyridine semicarbazone molecule (L) is tridentately attached to the copper atom via the N,N,O set of donor atoms. In compounds I and II, the Cu: L ratio is equal to 1: 1, whereas, in III, it is 1: 2. In complex I, the coordination sphere of the copper atom includes two nitrate ions with different structural functions in addition to the L ligand. The structure is built as a one-dimensional polymer in which the NO3 bidentate group fulfills a bridging function. The coordination polyhedron of the copper(2+) atom can be considered a distorted tetragonal bipyramid (4 + 1 + 1). Compound II has an ionic structure in which the main element is the [CuLCl2 · Cu(H2O)LCl]+ dimer. In the dimer, the copper atoms are linked via one of the μ2-bridging chlorine atoms. The coordination polyhedra of the central atoms of the Cu(H2)LCl and CuLCl2 complex fragments are tetragonal bipyramid and tetragonal pyramid, respectively. In compound III, the copper atom is octahedrally surrounded by two L ligands in the mer configuration.
4 citations
01 Jan 2009
TL;DR: In this article, a few selected examples to illustrate the biological effects of small air ions on chicken eggs and on laboratory animals were presented, in which different concentrations of ions, in different periods of development, solely or in association with physical or chemical factors.
Abstract: Electrical charged particles formed in the air, either negative or positive, can be created naturally or artificially by using an ion generator. The negative air ions have beneficial effects on humans and animals whilst the positive ones elicit the opposite effects. The paper presents a few selected examples to illustrate the biological effects of small air ions on chicken eggs and on laboratory animals. We used different concentrations of ions, in different periods of development, solely or in association with physical or chemical factors. Our studies confirm the results of other researchers with tradition in the field, that negative air ions have a normalization effect, of return to the normal the hematological parameters or histologically structure of modified organs and may become a valuable adjunct to other forms of therapy.
01 Jan 2009
TL;DR: Clinical environments are crowded with technology where devices from multiple vendors run into interoperability barriers, so systems of integrated medical devices support improvements in workflow and reductions in medical errors and healthcare costs to the benefit of patients throughout the continuum of care.
Abstract: Object: Clinical environments are crowded with technology where devices from multiple vendors run into interoperability barriers. Systems of integrated medical devices support improvements in workflow and reductions in medical errors and healthcare costs to the benefit of patients throughout the continuum of care.
TL;DR: It is concluded that ante partum ultrasound diagnosis of nuchal cord is not in itself an indication for CS delivery and there were no significant obstetric differences between the group with a prenatal diagnosis of umbilical cord loop who delivered by CS.
Abstract: Method. We compared the obstetric results for two groups of births: 344 vaginal deliveries in which nuchal cord was diagnosed during the second stage of labour, and 48 cases in which the diagnosis was made with an ultrasound scan ante partum and delivery was by caesarean section (CS). All were singleton term pregnancies with a cephalic presentation, and with no other significant associated pathology. Results. There were no significant obstetric differences between the group with a prenatal diagnosis of umbilical cord loop who delivered by CS and the group with a post partum diagnosis of umbilical cord loop who delivered vaginally. Conclusion. We concluded that ante partum ultrasound diagnosis of nuchal cord is not in itself an indication for CS delivery.
Journal Article•
TL;DR: The predictive value is amplified when the ER status is correlated with the PR status because the heterogeneous phenotypes are identified, especially the ER+÷PR- phenotype, which have an aggressive behavior and the lowest response to tamoxifen therapy.
Abstract: AIMS. Immunohistochemical evaluation of hormone receptors (ER, PR) and correlation of immunohistochemical and morpho-clinical data. METHOD. The study was performed on paraffin-embedded and HE stained tissues originating from 100 cases of invasive mammary carcinoma. Monoclonal antibodies anti-estrogen and anti progesterone receptors were used for the immunohistochemical study. The detection system was EnVision HRP and the visualization system was 3-3' diaminobenzidine tetrahydrochloride (DAB). The evaluation of the result was performed using the Allred score. REZULTS. The majority of the studied cases (57%) expressed both types of hormone receptors and in 32% of the cases the hormone receptors were completely absent. The rest of the cases presented a heterogeneous phenotype: 7% presented the ER-/PR+ type and 4%, the ER+/PR- type. Compared with the classical phenotype (ER+/PR-), ER+/PR- tumors were more frequent at patients over 50 years. The tumors with ER+/PR- were larger than the ER+/PR+ and they were of the invasive ductal carcinoma type with an Allred score for ER under 6. CONCLUSION. The predictive value is amplified when the ER status is correlated with the PR status because the heterogeneous phenotypes are identified, especially the ER+/PR- phenotype which have an aggressive behavior and the lowest response to tamoxifen therapy.
01 Jul 2009
TL;DR: The favorable effect of meloxicam on patients with CGD on a 30-day treatment phase reflected on the evolution of proteinuria and the effect on tubulo-interstitial lesions is considered to be a useful drug in the treatment of proteinuric glomerular diseases.
Abstract: Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that primarily has an antiproteinuric effect and is used for the treatment of chronic glomerular diseases. In chronic glomerular disease (CGD), proteinuria is involved in the production of tubulo-interstitial lesions and has an important role in their progression. CGD improves with steroid therapy and immunosuppression. In the case of a favorable outcome, a reduction in proteinuria is also attained. In some situations, this therapy is prohibited, requiring alternative medication. NSAIDs are one class of these alternative drugs; in addition to having anti-inflammatory actions, they also have antiproteinuric effects. The aim of the study has been to assess the effect of the anti-inflammatory treatment with meloxicam upon proteinuria as well as upon tubular lesions by determining urinary NAG in its dynamics. The study was performed on 12 patients with CGD, 6 of them with nephrotic syndrome. On all patients we administered treatment with meloxicam 15 mg/day, 30 days. On all patients we performed proteinuria and urinary N-acetyl b D glucosaminidase (NAG) at the beginning, after 7 days and after 30 days of treatment. A 24-hour urine collection was taken from all patients. The urinary protein concentration was determined with the use of the Dimension (Dade Behring, Inc., Newark, DE, USA) clinical chemistry system UCFP method. We found a decrease of proteinuria under treatment from 2.85 +/- 1.69 g/24h to 1.53 +/- 0.83 g/24h, which was significantly lower, compared to the initial measurement (p = 0.01878). After 30 days of treatment with meloxicam, urinary NAG decreased from 10.6 +/- 12.56 U/g creatinine to 6.44 +/- 7 U/g, a decrease that was statistically non-significant. We observed a strong correlation between initial urinary NAG and initial proteinuria ri = 0.924, p < 0.001 and between final urinary NAG and final proteinuria rf = 0.856, p < 0.001. Our study revealed the favorable effect of meloxicam on patients with CGD on a 30-day treatment phase reflected on the evolution of proteinuria. Only in one case we did reveal a possible deleterious effect of this treatment. The assessment of the effect on tubulo-interstitial lesions in this short treatment period through urinary NAG assessment indicated only a modest and statistically non-significant response. We consider that meloxicam can be a useful drug in the treatment of proteinuric glomerular diseases.
01 Jan 2009
TL;DR: In this paper, the results of investigation on concentrations and sources of volatile organic compounds in renovated and non-renovated residences were presented, and it was found that various volatile organic compound (VOCs) are present in the indoor environments.
Abstract: It has been found that various volatile organic compounds (VOC) are present in the indoor environments Studies on the volatile organic compounds have become one of current interests, since the VOCs’ impact on comfort and health of occupants has been recognized This paper describes the results of investigation on concentrations and sources of volatile organic compounds in renovated and non-renovated residences The concentration of volatile organic compounds in newly renovated residences is higher than those found in non renovated house Gas heating and cosmetics’ use were found to be important sources of VOCs in the undecorated residence The concentrations of total volatile organic compounds (TVOC) in the renovated houses and the not renovated house with gas heating were much higher than those found outdoors
01 Jan 2009
TL;DR: In this article, the bimanual dual-task interference was demonstrated through tapping experiments where periodic dominant hand tapping was shown to strongly interact with single stimulus evoked discrete taps of the non-dominant hand.
Abstract: The paper discusses the bimanual dual-task interference, demonstrated through tapping experiments where periodic dominant hand tapping was shown to strongly interact with single stimulus evoked discrete taps of the non-dominant hand. As a consequence, it proposes the progressive combination hypothesis ( which states that computation from sensory input to motor output could be generated progressively) to be reconsidered within this context.
01 Jan 2009
TL;DR: In premenstrual syndrome, very favorable effects were noted, confirming the hypothesis that serotonin and endorphins were involved in the mechanism of interaction between ions and biological systems.
Abstract: The paper represents a synthesis of the investigations made at the University of Medicine and Pharmacy, Cluj-Napoca, Romania, on the effects of the treatment with ionised air during the physical exercise in man or upon certain simptoms and neuro-psychic processes in girls with premenstrual syndrome. The treatment by ionised air was applied daily, for 2 weeks, using moderate ionic concentrations (16,000-18,000 small negative/cmc air). The duration of the daily treatment was 15-25 mins. In premenstrual syndrome, very favorable effects were noted, confirming the hypothesis that serotonin and endorphins were involved in the mechanism of interaction between ions and biological systems. In young sportsmen treated with negative air ions a better cardiovascular and respiratory adaptation to effort was observed: the pulse and blood pressure returned sooner to normal levels.