scispace - formally typeset
Search or ask a question
Institution

Hai phong University Of Medicine and Pharmacy

EducationHaiphong, Vietnam
About: Hai phong University Of Medicine and Pharmacy is a education organization based out in Haiphong, Vietnam. It is known for research contribution in the topics: Population & Health care. The organization has 620 authors who have published 403 publications receiving 8425 citations. The organization is also known as: Hai Phong Medical University.


Papers
More filters
Journal ArticleDOI
TL;DR: Stepping treatment down to a lower dose of FSC 100/50 microg twice daily is more effective than switching to an inhaled corticosteroid alone in patients achieving asthma control.
Abstract: Background Asthma control is the goal of treatment, but little data exist to support treatment strategies for stepping down treatment once control has been achieved. Objective We assessed whether either the long-acting β 2 -agonist or corticosteroid could be reduced without loss of asthma control once control had been attained with fluticasone propionate/salmeterol (FSC). Methods After 12 weeks of open-label treatment with FSC 250/50 μg twice daily, patients whose asthma was well controlled were randomized to FSC 100/50 μg twice daily or fluticasone propionate (FP) 250 μg twice daily. for 12 weeks. The primary endpoint was mean morning peak expiratory flow over the randomized study period. Secondary endpoints included symptom scores, rescue albuterol use, and asthma control. Results During open-label treatment, improvements from baseline were seen, and 435 of 641 patients (68%) achieved well controlled status during each of the last 4 weeks of this period. A total of 246 patients received FSC 100/50 μg twice daily and 238 FP 250 μg twice daily. The adjusted mean change in morning peak expiratory flow from the end of open-label treatment was −0.3 L/min for FSC and −13.2 L/min for FP (treatment difference, 12.9 L/min; 95% CI, 8.1-17.6; P Conclusion In patients achieving asthma control with FSC 250/50 μg twice daily, stepping treatment down to a lower dose of FSC 100/50 μg twice daily is more effective than switching to an inhaled corticosteroid alone.

85 citations

Journal ArticleDOI
TL;DR: The results indicate that mice lacking FAAH have a normal hemodynamic profile, and their increased responsiveness to anandamide-induced hypotension and cardiodepression is due to the decreased degradation of an andamide rather than an increase in target organ sensitivity to CB1 agonists.
Abstract: The endocannabinoid anandamide exerts neurobehavioral, cardiovascular, and immune-regulatory effects through cannabinoid receptors (CB). Fatty acid amide hydrolase (FAAH) is an enzyme responsible f...

80 citations

Journal ArticleDOI
01 Nov 2013-Europace
TL;DR: The results showed different practices in all the fields the authors investigated, nevertheless the survey also outlines a good adherence to the common standards and recommendations.
Abstract: The aim of this European Heart Rhythm Association (EHRA) survey was to assess clinical practice in relation to the tools and techniques used for cardiac implantable electronic devices procedures in the European countries. Responses to the questionnaire were received from 62 members of the EHRA research network. The survey involved high-, medium-, and low-volume implanting centres, performing, respectively, more than 200, 100-199 and under 100 implants per year. The following topics were explored: the side approach for implantation, surgical techniques for pocket incision, first venous access for lead implantation, preference of lead fixation, preferred coil number for implantable cardioverter-defibrillator (ICD) leads, right ventricular pacing site, generator placement site, subcutaneous ICD implantation, specific tools and techniques for cardiac resynchronization therapy (CRT), lead implantation sequence in CRT, coronary sinus cannulation technique, target site for left ventricular lead placement, strategy in left ventricular lead implant failure, mean CRT implantation time, optimization of the atrioventricular (AV) and ventriculo-ventricular intervals, CRT implants in patients with permanent atrial fibrillation, AV node ablation in patients with permanent AF. This panoramic view allows us to find out the operator preferences regarding the techniques and tools for device implantation in Europe. The results showed different practices in all the fields we investigated, nevertheless the survey also outlines a good adherence to the common standards and recommendations.

67 citations

Journal ArticleDOI
TL;DR: The data indicate that, in combination with the BH3 mimetic, Bh3I-2′, Apo2L/TRAIL synergistically induces apoptosis in C4-2 human prostate cancer cells through both the extrinsic and intrinsic apoptotic pathways.
Abstract: Overexpression of anti-apoptotic Bcl-2 family proteins may play an important role in the aggressive behavior of prostate cancer cells and their resistance to therapy. The Bcl-2 homology 3 domain (BH3) is a uniquely important functional element within the pro-apoptotic class of the Bcl-2-related proteins, mediating their ability to dimerize with other Bcl-2-related proteins and promote apoptosis. The BH3 inhibitors (BH3Is) function by disrupting the interactions mediated by the BH3 domain between pro- and anti-apoptotic members of the Bcl-2 family and liberating more Bax/Bak to induce mitochondrial membrane permeabilization. LNCaP-derived C4-2 human prostate cancer cells are quite resistant to non-tagged, human recombinant soluble Apo2 ligand [Apo2L, also Tumor necrosis factor (TNF)-related apoptosis-inducing ligand, TRAIL], a tumor specific drug that is now in clinical trials. However, when Apo2L/TRAIL was combined with the Bcl-xL inhibitor, BH3I-2', it induced apoptosis synergistically through activation of Caspase-8 and the proapoptotic Bcl-2 family member Bid, resulting in the activation of effector Caspase-3 and proteolytic cleavage of Poly(ADP-ribose) polymerase, events that were blocked by the pan-caspase inhibitor zVAD-fmk. Our data indicate that, in combination with the BH3 mimetic, BH3I-2', Apo2L/TRAIL synergistically induces apoptosis in C4-2 human prostate cancer cells through both the extrinsic and intrinsic apoptotic pathways.

64 citations

Journal ArticleDOI
TL;DR: It is hypothesized that brain reserve may have neuroprotective effects against late life depression and Investigating how rat models of increased cognitive reserve mitigate a chronic mild stress-elicited depression will afford new insights in the search for new therapeutic targets to treat this neuropsychiatric disorder.
Abstract: Depression is common and medically relevant illness that has been associated to a state of “accelerated aging” and can significantly compromise successful aging. In recent years, the concept of “brain reserve” has emerged to describe some individuals having an increased “baseline adaptive neuroplasticity”, providing greater dynamic capacity for adjusting and remodeling cortical circuits to various stressors. We hypothesize that brain reserve may have neuroprotective effects against late life depression. Here, we discuss the modulatory capacity of stress and corticosteroid hormones on hippocampal plasticity and neuronal viability in late life depression as well as the anti-depressive of ketamine and scopolamine mediated by stimulation of the mammalian target of rapamycin, increased inhibitory phosphorylation of GSK-3β, and increased synaptogenesis. This review shall shed light on complex neurobiological mechanisms that underpin late life depression and help to better understand neural correlates of resilience. Investigating how rat models of increased cognitive reserve mitigate a chronic mild stress-elicited depression will afford new insights in the search for new therapeutic targets to treat this neuropsychiatric disorder.

63 citations


Authors

Showing all 620 results

Network Information
Related Institutions (5)
Veterans Health Administration
98.4K papers, 4.8M citations

79% related

Centre for Addiction and Mental Health
10.3K papers, 449.6K citations

77% related

Group Health Cooperative
3.8K papers, 331.7K citations

77% related

Centre for Mental Health
4.2K papers, 174.3K citations

76% related

VA Boston Healthcare System
4.8K papers, 181K citations

76% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20223
202143
202036
201936
201845
201729