Hai phong University Of Medicine and Pharmacy

About: Hai phong University Of Medicine and Pharmacy is a education organization based out in Haiphong, Vietnam. It is known for research contribution in the topics: Population & Health care. The organization has 620 authors who have published 403 publications receiving 8425 citations. The organization is also known as: Hai Phong Medical University.

Modeling and Finite Element Analysis of the Human Knee Joint Affected by Osteoarthritis

Abstract: The paper presents a complex three-dimensional model of the human knee joint, containing bones, ligaments, menisci, tibial and femoral cartilages. To investigate the role of the articular cartilage in the developing of the osteoarthritis, to analyze and simulate the biomechanical behavior of the human knee joint, a finite element analysis was performed. The non-linearities are due to the presence of the contact elements modeled between components surfaces and to the nonlinear properties of the cartilage, applying a load of 800 N and 1500 N, for 0o in flexion. The results show that misalignment (valgus variation) could damage the articular cartilage because they increase the stress magnitude, that progressively produce articular cartilage damage and it enhances the osteoarthritis phenomenon due to mechanical factors. The displacements and the Von Mises stress distributions on the cartilage and menisci for the virtual prototype, considering an angle of 10 degrees for valgus, are presented. The obtained values are comparable with the values obtained by other authors.

Establishing and validating noninvasive prenatal testing procedure for fetal aneuploidies in Vietnam.

Abstract: Objective: Noninvasive prenatal testing (NIPT) for fetal aneuploidies has been widely adopted in developed countries. Despite the sharp decrease in the cost of massively parallel sequencing, the technical know-how and skilled personnel are still one of the major limiting factors for applying this technology to NIPT in low-income settings. Here, we present the establishment and validation of our NIPT procedure called triSure for detection of fetal aneuploidies. Methods: We established the triSure algorithm based on the difference in proportion of fetal and maternal fragments from the target chromosome to all chromosomes. Our algorithm was validated using a published data set and an in-house data set obtained from high-risk pregnant women in Vietnam who have undergone amniotic testing. Several other aneuploidy calling methods were also applied to the same data set to benchmark triSure performance. Results: The triSure algorithm showed similar accuracy to size-based method when comparing them using published data set. Using our in-house data set from 130 consecutive samples, we showed that triSure correctly identified the most samples (overall sensitivity and specificity of 0.983 and 0.986, respectively) compared to other methods tested including count-based, sized-based, RAPIDR and NIPTeR. Conclusions: We have demonstrated that our triSure NIPT procedure can be applied to pregnant women in low-income settings such as Vietnam, providing low-risk screening option to reduce the need for invasive diagnostic tests.

Study on Culture of Human Dental Pulp Stem Cells to Apply in Tissue Engineering

Abstract: Dental pulp cell research might open a promising application in tooth tissue regeneration. The aim of this study is to establish a protocol for in vitro culture the human dental pulp stem cells to apply in tissue engineering. Human premolar and impacted third molars were collected and disinfected. Dental pulp fragments were cultured with Dulbecco's Modified Eagle Medium: Nutrient Mixture F-12 (DMEM/F12) medium supplemented with 10% Fetal Bovine Serum (FBS). Dental pulp stem cells (DPSCs) were identified using proliferation assay, RT-PCR and flow cytometry. Growth of DPSCs on dentin surface was assessed by MTT assay. The study showed that we successfully isolated, cultured and characterized dental pulp cells by outgrowth method. Cultured population of cells expressed in high level of Oct4, CD146, CD90, CD44. DPSCs proliferated on chemically and mechanically treated dentin surface. This research provides important information and a basis for further investigations to establish dental tissue engineering protocols.

An effective RGB color selection for complex 3D object structure in scene graph systems

Abstract: The goal of this project is to develop a complete, fully detailed 3D interactive model of the human body and systems in the human body, and allow the user to interacts in 3D with all the elements of that system, to teach students about human anatomy. Some organs, which contain a lot of details about a particular anatomy, need to be accurately and fully described in minute detail, such as the brain, lungs, liver and heart. These organs are need have all the detailed descriptions of the medical information needed to learn how to do surgery on them, and should allow the user to add careful and precise marking to indicate the operative landmarks on the surgery location. Adding so many different items of information is challenging when the area to which the information needs to be attached is very detailed and overlaps with all kinds of other medical information related to the area. Existing methods to tag areas was not allowing us sufficient locations to attach the information to. Our solution combines a variety of tagging methods, which use the marking method by selecting the RGB color area that is drawn in the texture, on the complex 3D object structure. Then, it relies on those RGB color codes to tag IDs and create relational tables that store the related information about the specific areas of the anatomy. With this method of marking, it is possible to use the entire set of color values (R, G, B) to identify a set of anatomic regions, and this also makes it possible to define multiple overlapping regions.