Hai phong University Of Medicine and Pharmacy

About: Hai phong University Of Medicine and Pharmacy is a education organization based out in Haiphong, Vietnam. It is known for research contribution in the topics: Population & Health care. The organization has 620 authors who have published 403 publications receiving 8425 citations. The organization is also known as: Hai Phong Medical University.

Application of Vancomycin Therapeutic Drug Monitoring in a Vietnamese Private Hospital

Abstract: Vancomycin is a primary regimen for treating MRSA and other Gram-positive \(\upbeta\)-lactam–resistant organisms. But the problem is the resistance to vancomycin, the clinical and microbiological characteristics in which it is used is always changing. Therefore, we conducted this retrospective study to analysis benefits of Vancomycin TDM in clinical outcomes and discovered the factors affecting on the vancomycin maintenance dose. We conducted a follow-up on 137 patients using vancomycin divided into two groups, including the TDM and non-TDM users. The evaluation criteria included panoramic vancomycin use, infection status, renal function and treatment results after ten days. The total number of samples taken from 79 patients applied TDM were 116 and 73.3% of the samples reached the target trough concentration. Compared to 58 patients of the non-TDM group, applying TDM will reduce c-reactive protein (CRP) and improve treatment outcome. We also found that the vancomycin trough concentration, creatinine clearance, and weight contributed significantly (24.7%, 16.8% and 26.6%, respectively) to the inter-individual variability in vancomycin dose. The multiple linear regression model for vancomycin maintenance dose was built as the formula: Vancomycin maintenance dose (mg/kg) = 21.4 + 0.24 * vancomycin trough concentration (µg/mL) + 0.17 * Clcr(mL/min) − 0.26 * weight(kg) + 0.17 * age(years) − 0.03 * ΔCRP. Our study demonstrated the benefits of vancomycin TDM technology on clinical outcomes and improvement of infection situation. Furthermore, we have successfully indicated a strong relationship between vancomycin trough concentration, creatinine clearance, age, weight, ΔCRP and maintenance dose of vancomycin. Clinicians in the process of designing a regimen dose of vancomycin should comprehensively consider these factors in order to optimize the dose and reduce the adverse effect of vancomycin.

Role of the Fifth Copper Binding Site in Prion Conversion

Abstract: Prion diseases are fatal neurodegenerative disorders linked to the deposition of the abnormal prion protein isoform called PrPSc or prion. The key molecular events triggering the diseases are the conformational changes from the normal cellular α-helical prion protein PrPC to the pathological β-sheet enriched PrPSc. Therefore, understanding the mechanism and factors underlying the conversion process is essential to find possible diagnostic tools and treatments. Copper has long been known to correlate with neurodegenerative dysfunctions; PrPC is a copper binding protein via histidine residues in the highly conserved octapeptide repeats (OR) and the non-OR region located in the disordered N-terminal tail of the protein. The role of copper in facilitating protein aggregation and disease progression remains elusive. This study describes the impact of histidine residues on prion replication. By analyzing mouse PrP constructs that carry artificial mutations at histidines in the OR and non-OR, we provide cell evidence for the critical role of the non-OR copper binding site at histidine 95 in prion conversion. We also contribute to better understanding of the mechanisms and primary sites for prion conversion and replication. Our findings establish a platform for further studies aimed at elucidating the role of the H95 mutant in de novo prion diseases when expressed in transgenic mice.

Benign Lesions (Proliferations) and Tumors of the Breast

Abstract: Most of the lesions included in this chapter are frequently encountered in breast pathology and easy to diagnose. Some of them, however, may mimic radiologically, clinically, and pathologically an invasive carcinoma (the so-called pseudoinfiltrative lesions of the breast). Especially in these cases, the experience of the pathologist together with ancillary studies allow a correct diagnosis, while management requires a breast tumor board approach. Also, some of these lesions increase the risk of developing a malignancy, and closer follow-up should be considered in these patients.

Computational Study of Physicochemical Properties of the Monomers Used in Stomatology

Abstract: Monomers used in dentistry allow tackling shrinkage problem during polymerization of dental composites.These monomers may cross biomembranes, a phenomenon that can lead to various toxic responses. An important factor that express the lipophilicity of these compounds is the partition coefficient. This parameter allows assessment of the solubility of a monomer to another and, generally, of a material to another.Computational partition coefficients study of water / octanol for a series of monomeric compounds analyzed showed the contribution of chemical structures dependent descriptors of substances on this parameter. The purpose of the assessment of these molecular descriptors is to show their importance in the partition of the substances studied in two phases aqueous and lipid (n-octanol).This allows optimization of the action of compounds activity very useful in finding new monomers used in dental reconstruction.